Ganetespib overcomes resistance to PARP inhibitors in breast cancer by targeting core proteins in the DNA repair machinery.

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Drugging the Cancers Addicted to DNA Repair.Targeting protein quality control pathways in breast cancer.Constitutional mismatch repair-deficiency: current problems and emerging therapeutic strategies

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Ganetespib overcomes resistance to PARP inhibitors in breast cancer by targeting core proteins in the DNA repair machinery.

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2017 nî lūn-bûn

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Ganetespib overcomes resistanc ...... s in the DNA repair machinery.

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Ganetespib overcomes resistanc ...... s in the DNA repair machinery.

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Ganetespib overcomes resistanc ...... s in the DNA repair machinery.

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Ganetespib overcomes resistanc ...... s in the DNA repair machinery.

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Ganetespib overcomes resistanc ...... s in the DNA repair machinery.

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Ganetespib overcomes resistanc ...... s in the DNA repair machinery.

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Ganetespib overcomes resistanc ...... s in the DNA repair machinery.

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Daoli Niu

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Fen Xia

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Jing Liu

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Juhong Jiang

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Lin Fu

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Liping Li

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Wenwei Xu

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Yingying Gu

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Yuanzhi Lu

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Zhi Li

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P2860

High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial

Targeted inhibition of the molecular chaperone Hsp90 overcomes ALK inhibitor resistance in non-small cell lung cancer.

Role of PARP inhibitors in cancer biology and therapy

BRCA1 and HSP90 cooperate in homologous and non-homologous DNA double-strand-break repair and G2/M checkpoint activation.

Ganetespib (STA-9090), a nongeldanamycin HSP90 inhibitor, has potent antitumor activity in in vitro and in vivo models of non-small cell lung cancer.

Synergistic activity of the Hsp90 inhibitor ganetespib with taxanes in non-small cell lung cancer models.

The roles of BRCA1 and BRCA2 and associated proteins in the maintenance of genomic stability.

Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells.

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Ganetespib overcomes resistance to PARP inhibitors in breast cancer by targeting core proteins in the DNA repair machinery.

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P2860

P2860

Ganetespib overcomes resistance to PARP inhibitors in breast cancer by targeting core proteins in the DNA repair machinery.

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