A targeted knockdown screen of genes coding for phosphoinositide modulators identifies PIP4K2A as required for acute myeloid leukemia cell proliferation and survival.
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The function of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) explored using a specific inhibitor that targets the PI5P-binding siteMethod for Assaying the Lipid Kinase Phosphatidylinositol-5-phosphate 4-kinase α in Quantitative High-Throughput Screening (qHTS) Bioluminescent FormatThe Lipid Kinase PI5P4Kβ Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis.Exploring phosphatidylinositol 5-phosphate 4-kinase function.Polyphosphoinositide binding domains: Key to inositol lipid biology.Prevention of Proliferative Vitreoretinopathy by Suppression of Phosphatidylinositol 5-Phosphate 4-Kinases.In B cells, phosphatidylinositol 5-phosphate 4-kinase-α synthesizes PI(4,5)P2 to impact mTORC2 and Akt signalingThe Hidden Conundrum of Phosphoinositide Signaling in CancerA novel retroviral mutagenesis screen identifies prognostic genes in RUNX1 mediated myeloid leukemogenesisThe basal transcription complex component TAF3 transduces changes in nuclear phosphoinositides into transcriptional output.Structural reverse genetics study of the PI5P4Kβ-nucleotide complexes reveals the presence of the GTP bioenergetic system in mammalian cellsDual blockade of the lipid kinase PIP4Ks and mitotic pathways leads to cancer-selective lethality.Nuclear Inositide Signaling Via Phospholipase C.The chromatin-remodeling factor CHD4 is required for maintenance of childhood acute myeloid leukemia.Regulation of Hematopoietic Cell Development and Function Through Phosphoinositides.MGCD0103 induces apoptosis and simultaneously increases the expression of NF-κB and PD-L1 in classical Hodgkin's lymphoma
P2860
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P2860
A targeted knockdown screen of genes coding for phosphoinositide modulators identifies PIP4K2A as required for acute myeloid leukemia cell proliferation and survival.
description
2014 nî lūn-bûn
@nan
2014年の論文
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2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
2014年论文
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2014年论文
@zh-cn
name
A targeted knockdown screen of ...... ll proliferation and survival.
@en
A targeted knockdown screen of ...... ll proliferation and survival.
@nl
type
label
A targeted knockdown screen of ...... ll proliferation and survival.
@en
A targeted knockdown screen of ...... ll proliferation and survival.
@nl
prefLabel
A targeted knockdown screen of ...... ll proliferation and survival.
@en
A targeted knockdown screen of ...... ll proliferation and survival.
@nl
P2093
P2860
P356
P1433
P1476
A targeted knockdown screen of ...... ell proliferation and survival
@en
P2093
David R Jones
Gary J Spencer
Julian G Jude
Nullin Divecha
Tim D D Somerville
P2860
P2888
P304
P356
10.1038/ONC.2014.77
P407
P577
2014-03-31T00:00:00Z