Facile identification of dual FLT3-Aurora A inhibitors: a computer-guided drug design approach.

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Homology modeling of DFG-in FMS-like tyrosine kinase 3 (FLT3) and structure-based virtual screening for inhibitor identification.Discovery of BPR1K871, a quinazoline based, multi-kinase inhibitor for the treatment of AML and solid tumors: Rational design, synthesis, in vitro and in vivo evaluation

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Facile identification of dual FLT3-Aurora A inhibitors: a computer-guided drug design approach.

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Facile identification of dual ...... r-guided drug design approach.

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Chieh-Chien Lee

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Chun-Hwa Chen

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Chungming Chang

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Hui-Yi Shiao

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John T-A Hsu

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Kuei-Jung Yen

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Wen-Hsing Lin

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Yi-Yu Ke

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Yung Chang Hsu

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P2860

The protein kinase complement of the human genome

Structure-based drug design of novel Aurora kinase A inhibitors: structural basis for potency and specificity

Identification, SAR studies, and X-ray co-crystallographic analysis of a novel furanopyrimidine aurora kinase A inhibitor

Fast-forwarding hit to lead: aurora and epidermal growth factor receptor kinase inhibitor lead identification

Optimization of Imidazo[4,5- b ]pyridine-Based Kinase Inhibitors: Identification of a Dual FLT3/Aurora Kinase Inhibitor as an Orally Bioavailable Preclinical Development Candidate for the Treatment of Acute Myeloid Leukemia

Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules

Protein kinase inhibitor design by targeting the Asp-Phe-Gly (DFG) motif: the role of the DFG motif in the design of epidermal growth factor receptor inhibitors

FLT-3: a new focus in the understanding of acute leukemia

FMS-like tyrosine kinase 3 in normal hematopoiesis and acute myeloid leukemia

Therapeutic intervention in leukemias that express the activated fms-like tyrosine kinase 3 (FLT3): opportunities and challenges

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scholarly article

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10.1002/CMDC.201300571

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Hsing-Pang Hsieh

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2014-03-24T00:00:00Z

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Facile identification of dual FLT3-Aurora A inhibitors: a computer-guided drug design approach.

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P2860

P2860

Facile identification of dual FLT3-Aurora A inhibitors: a computer-guided drug design approach.

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