about
Determination of the Plk4/Sak consensus phosphorylation motif using peptide spots arraysInsights into the evolution of divergent nucleotide-binding mechanisms among pseudokinases revealed by crystal structures of human and mouse MLKLStructure of the complete extracellular domain of the common beta subunit of the human GM-CSF, IL-3, and IL-5 receptors reveals a novel dimer configurationConformational instability of the MARK3 UBA domain compromises ubiquitin recognition and promotes interaction with the adjacent kinase domainStructural studies of FF domains of the transcription factor CA150 provide insights into the organization of FF domain tandem arraysMurine interleukin-3: structure, dynamics, and conformational heterogeneity in solutionSOCS3 binds specific receptor–JAK complexes to control cytokine signaling by direct kinase inhibitionThe pseudokinase MLKL mediates necroptosis via a molecular switch mechanismCrystal structure of the mouse interleukin-3 β-receptor: insights into interleukin-3 binding and receptor activationStructure and Functional Characterization of the Conserved JAK Interaction Region in the Intrinsically Disordered N-Terminus of SOCS5Molecular Mechanism of CCAAT-Enhancer Binding Protein Recruitment by the TRIB1 PseudokinaseEvolution of Protein Quaternary Structure in Response to Selective Pressure for Increased ThermostabilityA new isoform of interleukin-3 receptor {alpha} with novel differentiation activity and high affinity binding modePoint mutation in the gene encoding p300 suppresses thrombocytopenia in Mpl-/- miceDe novo mutations in SMCHD1 cause Bosma arhinia microphthalmia syndrome and abrogate nasal development.The epigenetic regulator Smchd1 contains a functional GHKL-type ATPase domain.Laser-mediated rupture of chlamydial inclusions triggers pathogen egress and host cell necrosis.Suppressor of Cytokine Signaling (SOCS) 5 utilises distinct domains for regulation of JAK1 and interaction with the adaptor protein Shc-1.High yield production of a soluble human interleukin-3 variant from E. coli with wild-type bioactivity and improved radiolabeling properties.Functional characterization of c-Mpl ectodomain mutations that underlie congenital amegakaryocytic thrombocytopenia.MK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death.Critical roles for c-Myb in lymphoid priming and early B-cell developmentMechanistic insights into activation and SOCS3-mediated inhibition of myeloproliferative neoplasm-associated JAK2 mutants from biochemical and structural analysesExchange enhanced sensitivity gain for solvent-exchangeable protons in 2D 1H-15N heteronuclear correlation spectra acquired with band-selective pulses.The molecular regulation of Janus kinase (JAK) activationTwo modes of beta-receptor recognition are mediated by distinct epitopes on mouse and human interleukin-3.The role of interchain heterodisulfide formation in activation of the human common beta and mouse betaIL-3 receptors.An efficient high-throughput screening method for MYST family acetyltransferases, a new class of epigenetic drug targets.A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties.Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death.The evolving world of pseudoenzymes: proteins, prejudice and zombiesRegression of devil facial tumour disease following immunotherapy in immunised Tasmanian devils.Bio-Zombie: the rise of pseudoenzymes in biology.TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice.Suppression of cytokine signaling by SOCS3: characterization of the mode of inhibition and the basis of its specificity.Genome-wide binding and mechanistic analyses of Smchd1-mediated epigenetic regulationStructurally conserved erythrocyte-binding domain in Plasmodium provides a versatile scaffold for alternate receptor engagement.Analysis of the N-terminal region of human MLKL, as well as two distinct MLKL isoforms, reveals new insights into necroptotic cell deathIL-3, IL-5, and GM-CSF signaling: crystal structure of the human beta-common receptor.HSP90 activity is required for MLKL oligomerisation and membrane translocation and the induction of necroptotic cell death.
P50
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P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
James M Murphy
@ast
James M Murphy
@en
James M Murphy
@es
James M Murphy
@nl
James M Murphy
@sl
type
label
James M Murphy
@ast
James M Murphy
@en
James M Murphy
@es
James M Murphy
@nl
James M Murphy
@sl
prefLabel
James M Murphy
@ast
James M Murphy
@en
James M Murphy
@es
James M Murphy
@nl
James M Murphy
@sl
P108
P1053
B-4863-2017
P106
P108
P21
P31
P3829
P496
0000-0003-0195-3949