Soluble forms of polyQ-expanded huntingtin rather than large aggregates cause endoplasmic reticulum stress.
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Polyglutamine-rich suppressors of huntingtin toxicity act upstream of Hsp70 and Sti1 in spatial quality control of amyloid-like proteins.Dysregulation of system xc(-) expression induced by mutant huntingtin in a striatal neuronal cell line and in R6/2 miceMammalian ER mannosidase I resides in quality control vesicles, where it encounters its glycoprotein substrates.Transcription, epigenetics and ameliorative strategies in Huntington's Disease: a genome-wide perspectiveReduction of HIV-1 infectivity through endoplasmic reticulum-associated degradation-mediated Env depletion.ER stress-induced eIF2-alpha phosphorylation underlies sensitivity of striatal neurons to pathogenic huntingtinFolding Landscape of Mutant Huntingtin Exon1: Diffusible Multimers, Oligomers and Fibrils, and No Detectable Monomer.The emerging role of the first 17 amino acids of huntingtin in Huntington's diseaseThe VCP/p97 and YOD1 Proteins Have Different Substrate-dependent Activities in Endoplasmic Reticulum-associated Degradation (ERAD)Improved proteostasis in the secretory pathway rescues Alzheimer's disease in the mouse.Targeting TDP-43 in neurodegenerative diseases.Ubiquitin-dependent proteolysis in yeast cells expressing neurotoxic proteins.Physiological functions and pathobiology of TDP-43 and FUS/TLS proteins.Protein Quality Control in Health and Disease.TIA1 oxidation inhibits stress granule assembly and sensitizes cells to stress-induced apoptosis.Cellular stress responses in protein misfolding diseasesProteins Containing Expanded Polyglutamine Tracts and Neurodegenerative Disease.Assessing a peptidylic inhibitor-based therapeutic approach that simultaneously suppresses polyglutamine RNA- and protein-mediated toxicities in patient cells and Drosophila.Proteostasis of Huntingtin in Health and DiseaseA thiol probe for measuring unfolded protein load and proteostasis in cells.Optimization of trans-Splicing for Huntington's Disease RNA Therapy.Polyglutamine toxicity in yeast uncovers phenotypic variations between different fluorescent protein fusions.Pathways of cellular proteostasis in aging and disease.IKKβ and mutant huntingtin interactions regulate the expression of IL-34: implications for microglial-mediated neurodegeneration in HD.The absence of specific yeast heat-shock proteins leads to abnormal aggregation and compromised autophagic clearance of mutant Huntingtin proteins.When nature's robots go rogue: exploring protein homeostasis dysfunction and the implications for understanding human aging disease pathologies.ENC1 Modulates the Aggregation and Neurotoxicity of Mutant Huntingtin Through p62 Under ER Stress.Chaperone AMPylation modulates aggregation and toxicity of neurodegenerative disease-associated polypeptides.Target-Based Discovery of an Inhibitor of the Regulatory Phosphatase PPP1R15B
P2860
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P2860
Soluble forms of polyQ-expanded huntingtin rather than large aggregates cause endoplasmic reticulum stress.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Soluble forms of polyQ-expande ...... endoplasmic reticulum stress.
@en
Soluble forms of polyQ-expande ...... endoplasmic reticulum stress.
@nl
type
label
Soluble forms of polyQ-expande ...... endoplasmic reticulum stress.
@en
Soluble forms of polyQ-expande ...... endoplasmic reticulum stress.
@nl
prefLabel
Soluble forms of polyQ-expande ...... endoplasmic reticulum stress.
@en
Soluble forms of polyQ-expande ...... endoplasmic reticulum stress.
@nl
P2860
P356
P1476
Soluble forms of polyQ-expande ...... endoplasmic reticulum stress.
@en
P2093
Gerardo Z Lederkremer
Julia Leitman
P2860
P2888
P356
10.1038/NCOMMS3753
P407
P577
2013-01-01T00:00:00Z