The Vps35 D620N mutation linked to Parkinson's disease disrupts the cargo sorting function of retromer.
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Structural basis for different phosphoinositide specificities of the PX domains of sorting nexins regulating G-protein signalingRole of the Retromer Complex in Neurodegenerative DiseasesFocus on Extracellular Vesicles: Exosomes and Their Role in Protein Trafficking and Biomarker Potential in Alzheimer's and Parkinson's DiseaseVacuolar Protein Sorting Genes in Parkinson's Disease: A Re-appraisal of Mutations Detection Rate and Neurobiology of DiseaseGenetics in Parkinson disease: Mendelian versus non-Mendelian inheritanceParkinson's disease-associated mutant VPS35 causes mitochondrial dysfunction by recycling DLP1 complexesParkinson Disease-linked Vps35 R524W Mutation Impairs the Endosomal Association of Retromer and Induces α-Synuclein AggregationRetromer Ensures the Degradation of Autophagic Cargo by Maintaining Lysosome Function in DrosophilaVPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for α-Synuclein Degradation and Prevention of Pathogenesis of Parkinson's DiseaseA role for retromer in hepatitis C virus replicationMutation in VPS35 associated with Parkinson's disease impairs WASH complex association and inhibits autophagyVPS35, the Retromer Complex and Parkinson's Disease.VPS35 regulates parkin substrate AIMP2 toxicity by facilitating lysosomal clearance of AIMP2.High expression levels of the D686N Parkinson's disease mutation in VPS35 induces α-synuclein-dependent toxicity in yeastParkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration.In vivo evidence of pathogenicity of VPS35 mutations in the Drosophila.Dysregulation of protein trafficking in neurodegeneration.The role of the retromer complex in aging-related neurodegeneration: a molecular and genomic review.Cellular functions of WASP family proteins at a glance.A defect in the retromer accessory protein, SNX27, manifests by infantile myoclonic epilepsy and neurodegeneration.Retrograde trafficking of VMAT2 and its role in protein stability in non-neuronal cells.Metallothionein, Copper and Alpha-Synuclein in Alpha-Synucleinopathies.Genes associated with Parkinson's disease: regulation of autophagy and beyond.Targeting the Autophagy/Lysosomal Degradation Pathway in Parkinson's Disease.Sorting out release, uptake and processing of alpha-synuclein during prion-like spread of pathology.The Golgi-localized, gamma ear-containing, ARF-binding (GGA) protein family alters alpha synuclein (α-syn) oligomerization and secretion.Endocytic membrane trafficking and neurodegenerative disease.Insulin-Like Growth Factor-II/Cation-Independent Mannose 6-Phosphate Receptor in Neurodegenerative Diseases.Endolysosomal dysfunction in Parkinson's disease: Recent developments and future challenges.Soluble NSF attachment protein receptor molecular mimicry by a Legionella pneumophila Dot/Icm effector.β2-microglobulin amyloid fibrils are nanoparticles that disrupt lysosomal membrane protein trafficking and inhibit protein degradation by lysosomesRetromer binding to FAM21 and the WASH complex is perturbed by the Parkinson disease-linked VPS35(D620N) mutationGPCR Signaling and Trafficking: The Long and Short of It.Rabs, Membrane Dynamics, and Parkinson's Disease.Prelysosomal Compartments in the Unconventional Secretion of Amyloidogenic Seeds.The emerging role of retromer in neuroprotection.VPS35 pathogenic mutations confer no dominant toxicity but partial loss of function in Drosophila and genetically interact with parkin.Updated Insight into the Physiological and Pathological Roles of the Retromer Complex.NMR fingerprints of the drug-like natural-product space identify iotrochotazine A: a chemical probe to study Parkinson's disease.Control of mitochondrial homeostasis by endocytic regulatory proteins.
P2860
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P2860
The Vps35 D620N mutation linked to Parkinson's disease disrupts the cargo sorting function of retromer.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
The Vps35 D620N mutation linke ...... sorting function of retromer.
@en
The Vps35 D620N mutation linke ...... sorting function of retromer.
@nl
type
label
The Vps35 D620N mutation linke ...... sorting function of retromer.
@en
The Vps35 D620N mutation linke ...... sorting function of retromer.
@nl
prefLabel
The Vps35 D620N mutation linke ...... sorting function of retromer.
@en
The Vps35 D620N mutation linke ...... sorting function of retromer.
@nl
P2093
P50
P356
P1433
P1476
The Vps35 D620N mutation linke ...... sorting function of retromer.
@en
P2093
Andrea Bugarcic
Jordan Follett
Megha Mohan
Stephanie Tay
Suzanne J Norwood
P304
P356
10.1111/TRA.12136
P50
P577
2013-11-14T00:00:00Z