An erythroid enhancer of BCL11A subject to genetic variation determines fetal hemoglobin level. - Wikidata - awgldk - TriplyDB

An erythroid enhancer of BCL11A subject to genetic variation determines fetal hemoglobin level.

An erythroid enhancer of BCL11A subject to genetic variation determines fetal hemoglobin level.

http://www.wikidata.org/entity/Q39081873

about

Current and future alternative therapies for beta-thalassemia major Customizing the genome as therapy for the β-hemoglobinopathies The therapeutic potential of genome editing for β-thalassemia Genome-editing Technologies for Gene and Cell Therapy Towards a new era in medicine: therapeutic genome editing Enabling functional genomics with genome engineering Genomic approaches to identifying targets for treating β hemoglobinopathies Fetal globin gene repressors as drug targets for molecular therapies to treat the β-globinopathies Genome-scale neurogenetics: methodology and meaning Quantifying on- and off-target genome editing Sickle cell disease and H3Africa: enhancing genomic research on cardiovascular diseases in African patients Anemia: progress in molecular mechanisms and therapies Ctip1 Regulates the Balance between Specification of Distinct Projection Neuron Subtypes in Deep Cortical Layers.Transcriptional Dynamics at Brain Enhancers: from Functional Specialization to Neurodegeneration The selection and function of cell type-specific enhancers β-thalassemias: paradigmatic diseases for scientific discoveries and development of innovative therapies 2015 Clinical trials update in sickle cell anemia Therapeutic genome editing: prospects and challenges Erythro-megakaryocytic transcription factors associated with hereditary anemia Functional Characterization of the Osteoarthritis Susceptibility Mapping to CHST11-A Bioinformatics and Molecular Study BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis The European Hematology Association Roadmap for European Hematology Research: a consensus document Genome-wide Association Study of Platelet Count Identifies Ancestry-Specific Loci in Hispanic/Latino Americans Finding partners to play the music of regulation Hemoglobin switching's surprise: the versatile transcription factor BCL11A is a master repressor of fetal hemoglobin.Laying a solid foundation for Manhattan--'setting the functional basis for the post-GWAS era'.SAR1a promoter polymorphisms are not associated with fetal hemoglobin in patients with sickle cell disease from Cameroon.Erythropoietin signaling regulates heme biosynthesis.An international effort to cure a global health problem: A report on the 19th Hemoglobin Switching Conference.Predicting the impact of non-coding variants on DNA methylation.Short DNA sequence patterns accurately identify broadly active human enhancers Characterization of genomic deletion efficiency mediated by clustered regularly interspaced palindromic repeats (CRISPR)/Cas9 nuclease system in mammalian cells.Reactivation of developmentally silenced globin genes by forced chromatin looping.Characterization of transcription factor networks involved in umbilical cord blood CD34+ stem cells-derived erythropoiesis.Identifying causal variants at loci with multiple signals of association Genome wide association study of fetal hemoglobin in sickle cell anemia in Tanzania.KLF1-null neonates display hydrops fetalis and a deranged erythroid transcriptome.Editing the genome to introduce a beneficial naturally occurring mutation associated with increased fetal globin.Models of human core transcriptional regulatory circuitries.Association Between PIP4K2A Polymorphisms and Acute Lymphoblastic Leukemia Susceptibility.

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An erythroid enhancer of BCL11A subject to genetic variation determines fetal hemoglobin level.

http://www.wikidata.org/entity/Q39081873

description

2013 nî lūn-bûn

@nan

2013年の論文

@ja

2013年論文

@yue

2013年論文

@zh-hant

2013年論文

@zh-hk

2013年論文

@zh-mo

2013年論文

@zh-tw

2013年论文

@wuu

2013年论文

@zh

2013年论文

@zh-cn

name

An erythroid enhancer of BCL11 ...... rmines fetal hemoglobin level.

@en

An erythroid enhancer of BCL11 ...... rmines fetal hemoglobin level.

@nl

type

label

An erythroid enhancer of BCL11 ...... rmines fetal hemoglobin level.

@en

An erythroid enhancer of BCL11 ...... rmines fetal hemoglobin level.

@nl

prefLabel

An erythroid enhancer of BCL11 ...... rmines fetal hemoglobin level.

@en

An erythroid enhancer of BCL11 ...... rmines fetal hemoglobin level.

@nl

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SCIENCE.1242088

P1433

P1476

An erythroid enhancer of BCL11 ...... ermines fetal hemoglobin level

@en

P2093

Carrie Lin

http://www.w3.org/2001/XMLSchema#string

Daniel E Bauer

http://www.w3.org/2001/XMLSchema#string

Elenoe C Smith

http://www.w3.org/2001/XMLSchema#string

Guillaume Lettre

http://www.w3.org/2001/XMLSchema#string

Guo-Cheng Yuan

http://www.w3.org/2001/XMLSchema#string

Jian Xu

http://www.w3.org/2001/XMLSchema#string

John A Stamatoyannopoulos

http://www.w3.org/2001/XMLSchema#string

Matthew H Porteus

http://www.w3.org/2001/XMLSchema#string

Peter J Sabo

http://www.w3.org/2001/XMLSchema#string

Richard A Voit

http://www.w3.org/2001/XMLSchema#string

P2860

An integrated encyclopedia of DNA elements in the human genome

The accessible chromatin landscape of the human genome

Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia

Targeted chromosomal deletions in human cells using zinc finger nucleases

PLINK: a tool set for whole-genome association and population-based linkage analyses

Genome editing with engineered zinc finger nucleases

A TALE nuclease architecture for efficient genome editing

Developmental and species-divergent globin switching are driven by BCL11A

Bcl11a is essential for normal lymphoid development

Determination of haplotypes at structurally complex regions using emulsion haplotype fusion PCR

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scholarly article

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10.1126/SCIENCE.1242088

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6155

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342

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Sophia C Kamran

Matthew C Canver

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2013-10-01T00:00:00Z

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257649375

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24115442

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4018826

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