An ultraconserved Hox-Pbx responsive element resides in the coding sequence of Hoxa2 and is active in rhombomere 4.
about
A high-resolution map of human evolutionary constraint using 29 mammalsExonic remnants of whole-genome duplication reveal cis-regulatory function of coding exonsTALE transcription factors during early development of the vertebrate brain and eyeAbnormal dosage of ultraconserved elements is highly disfavored in healthy cells but not cancer cellsA regulatory module embedded in the coding region of Hoxa2 controls expression in rhombomere 2The evolution of ultraconserved elements with different phylogenetic originsSynonymous constraint elements show a tendency to encode intrinsically disordered protein segmentsHox specificity unique roles for cofactors and collaborators.The Pbx interaction motif of Hoxa1 is essential for its oncogenic activityExploration for functional nucleotide sequence candidates within coding regions of mammalian genesTranscriptional enhancers in protein-coding exons of vertebrate developmental genes.Coding exons function as tissue-specific enhancers of nearby genesGenomic selection identifies vertebrate transcription factor Fezf2 binding sites and target genes.DNA shape, genetic codes, and evolutionSystematic dissection of coding exons at single nucleotide resolution supports an additional role in cell-specific transcriptional regulation.Locating protein-coding sequences under selection for additional, overlapping functions in 29 mammalian genomes.Molecular Analysis of the HOXA2-Dependent Degradation of RCHY1.Genome-wide occupancy links Hoxa2 to Wnt-β-catenin signaling in mouse embryonic development.Genetic diversity and signatures of selection in various goat breeds revealed by genome-wide SNP markers.Combinatorial Gene Regulatory Functions Underlie Ultraconserved Elements in Drosophila.The mystery of extreme non-coding conservation.Chromatin and epigenetic features of long-range gene regulation.Biochemistry of the tale transcription factors PREP, MEIS, and PBX in vertebrates.Segmental arithmetic: summing up the Hox gene regulatory network for hindbrain development in chordates.The homeodomain transcription factor Hoxa2 interacts with and promotes the proteasomal degradation of the E3 ubiquitin protein ligase RCHY1.The role of Pbx1 in T cells.Hundreds of conserved non-coding genomic regions are independently lost in mammals.The G allele of SNP E1/A118G at the mu-opioid receptor gene locus shows genomic evidence of recent positive selection.Conserved non-coding elements: developmental gene regulation meets genome organization.Functional and Comparative Genomics of Hoxa2 Gene cis-Regulatory Elements: Evidence for Evolutionary Modification of Ancestral Core Element Activity.
P2860
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P2860
An ultraconserved Hox-Pbx responsive element resides in the coding sequence of Hoxa2 and is active in rhombomere 4.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
An ultraconserved Hox-Pbx resp ...... and is active in rhombomere 4.
@en
An ultraconserved Hox-Pbx resp ...... and is active in rhombomere 4.
@nl
type
label
An ultraconserved Hox-Pbx resp ...... and is active in rhombomere 4.
@en
An ultraconserved Hox-Pbx resp ...... and is active in rhombomere 4.
@nl
prefLabel
An ultraconserved Hox-Pbx resp ...... and is active in rhombomere 4.
@en
An ultraconserved Hox-Pbx resp ...... and is active in rhombomere 4.
@nl
P2093
P2860
P356
P1476
An ultraconserved Hox-Pbx resp ...... and is active in rhombomere 4.
@en
P2093
Allan Guiguen
Christelle Matis
Filippo M Rijli
Jacques J Picard
Omar Abdel Samad
René Rezsohazy
Sophie Remacle
Xavier Lampe
P2860
P304
P356
10.1093/NAR/GKN148
P407
P577
2008-04-16T00:00:00Z