ETS factors reprogram the androgen receptor cistrome and prime prostate tumorigenesis in response to PTEN loss. - Wikidata - awgldk - TriplyDB

ETS factors reprogram the androgen receptor cistrome and prime prostate tumorigenesis in response to PTEN loss.

ETS factors reprogram the androgen receptor cistrome and prime prostate tumorigenesis in response to PTEN loss.

http://www.wikidata.org/entity/Q39132148

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Biologic and clinical significance of androgen receptor variants in castration resistant prostate cancer Oncolytic adenovirus-mediated therapy for prostate cancer Translating insights of AR signaling from mouse models A small molecule inhibitor of ETV1, YK-4-279, prevents prostate cancer growth and metastasis in a mouse xenograft model A targetable GATA2-IGF2 axis confers aggressiveness in lethal prostate cancer Prostate Cancer: Epigenetic Alterations, Risk Factors, and Therapy N-Myc Induces an EZH2-Mediated Transcriptional Program Driving Neuroendocrine Prostate Cancer ETS (E26 transformation-specific) up-regulation of the transcriptional co-activator TAZ promotes cell migration and metastasis in prostate cancer.ERG induces taxane resistance in castration-resistant prostate cancer Structured and disordered regions cooperatively mediate DNA-binding autoinhibition of ETS factors ETV1, ETV4 and ETV5.Androgen synthesis inhibitors in the treatment of castration-resistant prostate cancer.HES6 drives a critical AR transcriptional programme to induce castration-resistant prostate cancer through activation of an E2F1-mediated cell cycle network.ETS Related Gene mediated Androgen Receptor Aggregation and Endoplasmic Reticulum Stress in Prostate Cancer Development.The ETS family member GABPα modulates androgen receptor signalling and mediates an aggressive phenotype in prostate cancer Recurrent prostate cancer genomic alterations predict response to brachytherapy treatment Androgen receptor functions in prostate cancer development and progression Prostate tumor development and androgen receptor function alterations in a new mouse model with ERG overexpression and PTEN inactivation Molecular pathways and targets in prostate cancer Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer The oxidative demethylase ALKBH3 marks hyperactive gene promoters in human cancer cells PTEN deficiency mediates a reciprocal response to IGFI and mTOR inhibition.Organoid cultures derived from patients with advanced prostate cancer.Genomic rearrangements in prostate cancer.In silico functional pathway annotation of 86 established prostate cancer risk variants.PTEN protein loss and clinical outcome from castration-resistant prostate cancer treated with abiraterone acetate.Interaction of the Androgen Receptor, ETV1, and PTEN Pathways in Mouse Prostate Varies with Pathological Stage and Predicts Cancer Progression.Androgen receptor and chemokine receptors 4 and 7 form a signaling axis to regulate CXCL12-dependent cellular motility Expression of ERG protein in prostate cancer: variability and biological correlates.The transcription factor ERG increases expression of neurotransmitter receptors on prostate cancer cells.Fusion transcript loci share many genomic features with non-fusion loci.Genome Wide Mapping of NR4A Binding Reveals Cooperativity with ETS Factors to Promote Epigenetic Activation of Distal Enhancers in Acute Myeloid Leukemia Cells Loss of miR-449a in ERG-associated prostate cancer promotes the invasive phenotype by inducing SIRT1.Lessons from tissue compartment-specific analysis of androgen receptor alterations in prostate cancer.A Tmprss2-CreERT2 Knock-In Mouse Model for Cancer Genetic Studies on Prostate and Colon.SPOP mutation leads to genomic instability in prostate cancer.PTEN loss in circulating tumour cells correlates with PTEN loss in fresh tumour tissue from castration-resistant prostate cancer patients Targeting Transcription Factors in Cancer Leukemia-Associated Cohesin Mutants Dominantly Enforce Stem Cell Programs and Impair Human Hematopoietic Progenitor Differentiation.The androgen receptor cistrome is extensively reprogrammed in human prostate tumorigenesis Histone demethylase JMJD2A drives prostate tumorigenesis through transcription factor ETV1.

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ETS factors reprogram the androgen receptor cistrome and prime prostate tumorigenesis in response to PTEN loss.

http://www.wikidata.org/entity/Q39132148

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ETS factors reprogram the andr ...... esis in response to PTEN loss.

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Brett S Carver

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Charles L Sawyers

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Howard I Scher

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Inna Sirota

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John Wongvipat

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Phillip J Iaquinta

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Ping Chi

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Shira Rockowitz

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Tambudzai Shamu

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Yu Chen

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Model-based analysis of ChIP-Seq (MACS)

An integrated network of androgen receptor, polycomb, and TMPRSS2-ERG gene fusions in prostate cancer progression

A transcriptional repressor co-regulatory network governing androgen response in prostate cancers

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.

Notch signaling controls multiple steps of pancreatic differentiation

Antitumour activity of MDV3100 in castration-resistant prostate cancer: a phase 1-2 study

Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities

FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus

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