ETS factors reprogram the androgen receptor cistrome and prime prostate tumorigenesis in response to PTEN loss.
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Biologic and clinical significance of androgen receptor variants in castration resistant prostate cancerOncolytic adenovirus-mediated therapy for prostate cancerTranslating insights of AR signaling from mouse modelsA small molecule inhibitor of ETV1, YK-4-279, prevents prostate cancer growth and metastasis in a mouse xenograft modelA targetable GATA2-IGF2 axis confers aggressiveness in lethal prostate cancerProstate Cancer: Epigenetic Alterations, Risk Factors, and TherapyN-Myc Induces an EZH2-Mediated Transcriptional Program Driving Neuroendocrine Prostate CancerETS (E26 transformation-specific) up-regulation of the transcriptional co-activator TAZ promotes cell migration and metastasis in prostate cancer.ERG induces taxane resistance in castration-resistant prostate cancerStructured and disordered regions cooperatively mediate DNA-binding autoinhibition of ETS factors ETV1, ETV4 and ETV5.Androgen synthesis inhibitors in the treatment of castration-resistant prostate cancer.HES6 drives a critical AR transcriptional programme to induce castration-resistant prostate cancer through activation of an E2F1-mediated cell cycle network.ETS Related Gene mediated Androgen Receptor Aggregation and Endoplasmic Reticulum Stress in Prostate Cancer Development.The ETS family member GABPα modulates androgen receptor signalling and mediates an aggressive phenotype in prostate cancerRecurrent prostate cancer genomic alterations predict response to brachytherapy treatmentAndrogen receptor functions in prostate cancer development and progressionProstate tumor development and androgen receptor function alterations in a new mouse model with ERG overexpression and PTEN inactivationMolecular pathways and targets in prostate cancerTherapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancerThe oxidative demethylase ALKBH3 marks hyperactive gene promoters in human cancer cellsPTEN deficiency mediates a reciprocal response to IGFI and mTOR inhibition.Organoid cultures derived from patients with advanced prostate cancer.Genomic rearrangements in prostate cancer.In silico functional pathway annotation of 86 established prostate cancer risk variants.PTEN protein loss and clinical outcome from castration-resistant prostate cancer treated with abiraterone acetate.Interaction of the Androgen Receptor, ETV1, and PTEN Pathways in Mouse Prostate Varies with Pathological Stage and Predicts Cancer Progression.Androgen receptor and chemokine receptors 4 and 7 form a signaling axis to regulate CXCL12-dependent cellular motilityExpression of ERG protein in prostate cancer: variability and biological correlates.The transcription factor ERG increases expression of neurotransmitter receptors on prostate cancer cells.Fusion transcript loci share many genomic features with non-fusion loci.Genome Wide Mapping of NR4A Binding Reveals Cooperativity with ETS Factors to Promote Epigenetic Activation of Distal Enhancers in Acute Myeloid Leukemia CellsLoss of miR-449a in ERG-associated prostate cancer promotes the invasive phenotype by inducing SIRT1.Lessons from tissue compartment-specific analysis of androgen receptor alterations in prostate cancer.A Tmprss2-CreERT2 Knock-In Mouse Model for Cancer Genetic Studies on Prostate and Colon.SPOP mutation leads to genomic instability in prostate cancer.PTEN loss in circulating tumour cells correlates with PTEN loss in fresh tumour tissue from castration-resistant prostate cancer patientsTargeting Transcription Factors in CancerLeukemia-Associated Cohesin Mutants Dominantly Enforce Stem Cell Programs and Impair Human Hematopoietic Progenitor Differentiation.The androgen receptor cistrome is extensively reprogrammed in human prostate tumorigenesisHistone demethylase JMJD2A drives prostate tumorigenesis through transcription factor ETV1.
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P2860
ETS factors reprogram the androgen receptor cistrome and prime prostate tumorigenesis in response to PTEN loss.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
ETS factors reprogram the andr ...... esis in response to PTEN loss.
@en
ETS factors reprogram the andr ...... esis in response to PTEN loss.
@nl
type
label
ETS factors reprogram the andr ...... esis in response to PTEN loss.
@en
ETS factors reprogram the andr ...... esis in response to PTEN loss.
@nl
prefLabel
ETS factors reprogram the andr ...... esis in response to PTEN loss.
@en
ETS factors reprogram the andr ...... esis in response to PTEN loss.
@nl
P2093
P2860
P50
P356
P1433
P1476
ETS factors reprogram the andr ...... esis in response to PTEN loss.
@en
P2093
Brett S Carver
Charles L Sawyers
Howard I Scher
Inna Sirota
John Wongvipat
Phillip J Iaquinta
Shira Rockowitz
Tambudzai Shamu
P2860
P2888
P304
P356
10.1038/NM.3216
P407
P577
2013-06-30T00:00:00Z
P5875
P6179
1019428029