From basic apoptosis discoveries to advanced selective BCL-2 family inhibitors.
about
Regulation of Apoptosis during Flavivirus Infection.Influenza Virus Infection, Interferon Response, Viral Counter-Response, and Apoptosis.Rapidly inducible Cas9 and DSB-ddPCR to probe editing kinetics.Oleic acid induces apoptosis and autophagy in the treatment of Tongue Squamous cell carcinomas.Fork Head Box Class O1 (FOXO1) Activates Bim Expression to Mediate Cardiac Apoptosis in Chronic Intermittent Hypoxia-Induced Cardiac Hypertrophy.Antiviral Properties of Chemical Inhibitors of Cellular Anti-Apoptotic Bcl-2 Proteins.Emerging therapies for acute myeloid leukemia: translating biology into the clinic.Extra-mitochondrial prosurvival BCL-2 proteins regulate gene transcription by inhibiting the SUFU tumour suppressor.Targeting apoptosis in acute myeloid leukaemia.Hypoxia Induces Apoptosis through HIF-1α Signaling Pathway in Human Uterosacral Ligaments of Pelvic Organ Prolapse.Inhibitory Effect of Arachis hypogaea (Peanut) and Its Phenolics against Methylglyoxal-Derived Advanced Glycation End Product Toxicity.Intrauterine growth retardation promotes fetal intestinal autophagy in rats via the mechanistic target of rapamycin pathway.Found in Translation: How Preclinical Research Is Guiding the Clinical Development of the BCL2-Selective Inhibitor Venetoclax.Discovery of a cryptic peptide-binding site on PCSK9 and design of antagonists.MOMP, cell suicide as a BCL-2 family business.Demethylzeylasteral inhibits cell proliferation and induces apoptosis through suppressing MCL1 in melanoma cells.The BCL-2 arbiters of apoptosis and their growing role as cancer targets.Synergistic cytotoxicity of a prostate cancer-specific immunotoxin in combination with the BH3 mimetic ABT-737.Regulation of stressed-induced cell death by the Bcl-2 family of apoptotic proteins.High-Throughput Chemical Probing of Full-Length Protein-Protein Interactions.Crystal structure and functional characterization of SF216 from Shigella flexneri.Post-Transcriptional Regulation of Anti-Apoptotic BCL2 Family Members.Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.RNA Polymerase Tags To Monitor Multidimensional Protein-Protein Interactions Reveal Pharmacological Engagement of Bcl-2 Proteins.Novel synthetic drugs currently in clinical development for chronic lymphocytic leukemia.Current NMR Techniques for Structure-Based Drug Discovery.Cell death-based treatment of glioblastoma.miR-663 sustains NSCLC by inhibiting mitochondrial outer membrane permeabilization (MOMP) through PUMA/BBC3 and BTG2.Deubiquitinase USP13 dictates MCL1 stability and sensitivity to BH3 mimetic inhibitors.One-step synthesis of gene carrier via gamma irradiation and its application in tumor gene therapy.Combination of betulinic acid with diazen-1-ium-1,2-diolate nitric oxide moiety donating a novel anticancer candidate.A Mitochondrial-targeted purine-based HSP90 antagonist for leukemia therapy.Ghrelin, MicroRNAs, and Critical Limb Ischemia: Hungering for a Novel Treatment Option.The T-cell fingerprint of MALT1 paracaspase revealed by selective inhibition.Bcl-2 on the brink of breakthroughs in cancer treatment.The novel TRAIL-receptor agonist APG350 exerts superior therapeutic activity in pancreatic cancer cells.In silico approaches to identify novel myeloid cell leukemia-1 (Mcl-1) inhibitors for treatment of cancer.Glycycoumarin Sensitizes Liver Cancer Cells to ABT-737 by Targeting De Novo Lipogenesis and TOPK-Survivin Axis.Mineral trioxide aggregate affects cell viability and induces apoptosis of stem cells from human exfoliated deciduous teeth.S55746 is a novel orally active BCL-2 selective and potent inhibitor that impairs hematological tumor growth.
P2860
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P2860
From basic apoptosis discoveries to advanced selective BCL-2 family inhibitors.
description
2017 nî lūn-bûn
@nan
2017年の論文
@ja
2017年論文
@yue
2017年論文
@zh-hant
2017年論文
@zh-hk
2017年論文
@zh-mo
2017年論文
@zh-tw
2017年论文
@wuu
2017年论文
@zh
2017年论文
@zh-cn
name
From basic apoptosis discoveries to advanced selective BCL-2 family inhibitors.
@en
From basic apoptosis discoveries to advanced selective BCL-2 family inhibitors.
@nl
type
label
From basic apoptosis discoveries to advanced selective BCL-2 family inhibitors.
@en
From basic apoptosis discoveries to advanced selective BCL-2 family inhibitors.
@nl
prefLabel
From basic apoptosis discoveries to advanced selective BCL-2 family inhibitors.
@en
From basic apoptosis discoveries to advanced selective BCL-2 family inhibitors.
@nl
P2093
P356
P1476
From basic apoptosis discoveries to advanced selective BCL-2 family inhibitors.
@en
P2093
Andrew J Souers
Avi Ashkenazi
Joel D Leverson
Wayne J Fairbrother
P2888
P304
P356
10.1038/NRD.2016.253
P577
2017-02-17T00:00:00Z