Pharmacologic activation of PKM2 slows lung tumor xenograft growth.
about
Pyruvate kinase: Function, regulation and role in cancerReview of aerobic glycolysis and its key enzymes - new targets for lung cancer therapyMetabolic reprogramming in cancer cells: glycolysis, glutaminolysis, and Bcl-2 proteins as novel therapeutic targets for cancerOleanolic acid suppresses aerobic glycolysis in cancer cells by switching pyruvate kinase type M isoformsAnalysis and interpretation of transcriptomic data obtained from extended Warburg effect genes in patients with clear cell renal cell carcinoma.Cell-state-specific metabolic dependency in hematopoiesis and leukemogenesisPKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells.Activators of PKM2 in cancer metabolism.A novel pyruvate kinase M2 activator compound that suppresses lung cancer cell viability under hypoxiaOverexpression of pyruvate kinase M2 associates with aggressive clinicopathological features and unfavorable prognosis in oral squamous cell carcinoma.MYCN controls an alternative RNA splicing program in high-risk metastatic neuroblastoma.PKM2 and cancer: The function of PKM2 beyond glycolysis.Pyruvate kinase M2 overexpression and poor prognosis in solid tumors of digestive system: evidence from 16 cohort studies.Post-translational modifications and the Warburg effect.Metabolic modulation of cancer: a new frontier with great translational potential.Emerging Approaches for Targeting Metabolic Vulnerabilities in Malignant Glioma.Overexpression of metabolic markers PKM2 and LDH5 correlates with aggressive clinicopathological features and adverse patient prognosis in tongue cancer.Pyruvate kinase M knockdown-induced signaling via AMP-activated protein kinase promotes mitochondrial biogenesis, autophagy, and cancer cell survival.Cytosolic PKM2 stabilizes mutant EGFR protein expression through regulating HSP90-EGFR association.Natural Product Micheliolide (MCL) Irreversibly Activates Pyruvate Kinase M2 and Suppresses Leukemia.Novel strategies for targeting leukemia stem cells: sounding the death knell for blood cancer.Crosstalk between the Warburg effect, redox regulation and autophagy induction in tumourigenesis.
P2860
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P2860
Pharmacologic activation of PKM2 slows lung tumor xenograft growth.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Pharmacologic activation of PKM2 slows lung tumor xenograft growth.
@en
Pharmacologic activation of PKM2 slows lung tumor xenograft growth.
@nl
type
label
Pharmacologic activation of PKM2 slows lung tumor xenograft growth.
@en
Pharmacologic activation of PKM2 slows lung tumor xenograft growth.
@nl
prefLabel
Pharmacologic activation of PKM2 slows lung tumor xenograft growth.
@en
Pharmacologic activation of PKM2 slows lung tumor xenograft growth.
@nl
P2093
P1476
Pharmacologic activation of PKM2 slows lung tumor xenograft growth
@en
P2093
Adrianne Clifford
Anna Senina
David Vollmer
Jeremy Bullough
K Mark Parnell
Kevin Wright
Koc-Kan Ho
Marc O'Reilly
P304
P356
10.1158/1535-7163.MCT-13-0026
P577
2013-05-29T00:00:00Z