Discovery of INCB9471, a Potent, Selective, and Orally Bioavailable CCR5 Antagonist with Potent Anti-HIV-1 Activity

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CCR5 receptor antagonists in preclinical to phase II clinical development for treatment of HIV.

P2860

Q38803127-7549D023-4E2C-4C8C-AFE1-6F770B285E02

P2860

Discovery of INCB9471, a Potent, Selective, and Orally Bioavailable CCR5 Antagonist with Potent Anti-HIV-1 Activity

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http://www.wikidata.org/entity/Q39158970

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2010 nî lūn-bûn

@nan

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

2010年论文

@zh

2010年论文

@zh-cn

name

Discovery of INCB9471, a Poten ...... ith Potent Anti-HIV-1 Activity

@en

Discovery of INCB9471, a Poten ...... th Potent Anti-HIV-1 Activity.

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type

Item

label

Discovery of INCB9471, a Poten ...... ith Potent Anti-HIV-1 Activity

@en

Discovery of INCB9471, a Poten ...... th Potent Anti-HIV-1 Activity.

@nl

prefLabel

Discovery of INCB9471, a Poten ...... ith Potent Anti-HIV-1 Activity

@en

Discovery of INCB9471, a Poten ...... th Potent Anti-HIV-1 Activity.

@nl

P1476

Discovery of INCB9471, a Poten ...... ith Potent Anti-HIV-1 Activity

@en

P2093

Anlai Wang

http://www.w3.org/2001/XMLSchema#string

Bitao Zhao

http://www.w3.org/2001/XMLSchema#string

Brian Metcalf

http://www.w3.org/2001/XMLSchema#string

Changsheng Zheng

http://www.w3.org/2001/XMLSchema#string

Chu-Biao Xue

http://www.w3.org/2001/XMLSchema#string

David Meloni

http://www.w3.org/2001/XMLSchema#string

Fredric Baribaud

http://www.w3.org/2001/XMLSchema#string

Ganfeng Cao

http://www.w3.org/2001/XMLSchema#string

Gregory Hollis

http://www.w3.org/2001/XMLSchema#string

Hao Feng

http://www.w3.org/2001/XMLSchema#string

P2860

Identification of a major co-receptor for primary isolates of HIV-1

Molecular cloning and functional expression of a new human CC-chemokine receptor gene

Discovery and characterization of vicriviroc (SCH 417690), a CCR5 antagonist with potent activity against human immunodeficiency virus type 1

Piperazine-based CCR5 antagonists as HIV-1 inhibitors. IV. Discovery of 1-[(4,6-dimethyl-5-pyrimidinyl)carbonyl]- 4-[4-[2-methoxy-1(R)-4-(trifluoromethyl)phenyl]ethyl-3(S)-methyl-1-piperazinyl]- 4-methylpiperidine (Sch-417690/Sch-D), a potent, highl

Antiviral activity, pharmacokinetics and safety of vicriviroc, an oral CCR5 antagonist, during 14-day monotherapy in HIV-infected adults

CC CKR5: a RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1

Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection

HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5

Discovery of novel, potent, and selective small-molecule CCR5 antagonists as anti-HIV-1 agents: synthesis and biological evaluation of anilide derivatives with a quaternary ammonium moiety.

Maraviroc (UK-427,857), a potent, orally bioavailable, and selective small-molecule inhibitor of chemokine receptor CCR5 with broad-spectrum anti-human immunodeficiency virus type 1 activity.

P304

483-487

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scholarly article

P356

10.1021/ML1001536

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P433

http://www.w3.org/2001/XMLSchema#string

P478

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D A Keller

P577

2010-08-25T00:00:00Z

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P698

24900235

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P932

4007949

http://www.w3.org/2001/XMLSchema#string

Discovery of INCB9471, a Potent, Selective, and Orally Bioavailable CCR5 Antagonist with Potent Anti-HIV-1 Activity

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P2860

P2860

Discovery of INCB9471, a Potent, Selective, and Orally Bioavailable CCR5 Antagonist with Potent Anti-HIV-1 Activity

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P1433

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P2093

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