Elevation of receptor tyrosine kinases by small molecule AKT inhibitors in prostate cancer is mediated by Pim-1.
about
Targeting the Pim kinases in multiple myelomaPim-1 kinase as cancer drug target: An updateTargeting the PIM protein kinases for the treatment of a T-cell acute lymphoblastic leukemia subsetPim-1 kinase is a target of miR-486-5p and eukaryotic translation initiation factor 4E, and plays a critical role in lung cancer.Suppression of feedback loops mediated by PI3K/mTOR induces multiple overactivation of compensatory pathways: an unintended consequence leading to drug resistance.Pim1 kinase is upregulated in glioblastoma multiforme and mediates tumor cell survival.Dual PI3K/mTOR Inhibitors Induce Rapid Overactivation of the MEK/ERK Pathway in Human Pancreatic Cancer Cells through Suppression of mTORC2.Tumor-Targeted Synergistic Blockade of MAPK and PI3K from a Layer-by-Layer Nanoparticle.Downregulation of microRNA‑33a promotes cyclin‑dependent kinase 6, cyclin D1 and PIM1 expression and gastric cancer cell proliferation.Activation of Pim Kinases Is Sufficient to Promote Resistance to MET Small-Molecule Inhibitors.Pim-3 is a Critical Risk Factor in Development and Prognosis of Prostate Cancer.High glucose-induced resistance to 5-fluorouracil in pancreatic cancer cells alleviated by 2-deoxy-D-glucose.PIM kinases as therapeutic targets against advanced melanoma.PIM kinase (and Akt) biology and signaling in tumors.Regulation of prostate stromal fibroblasts by the PIM1 protein kinase.Mutant PIK3CA controls DUSP1-dependent ERK 1/2 activity to confer response to AKT target therapy.The Pim-1 protein kinase is an important regulator of MET receptor tyrosine kinase levels and signalingPIM-1 mRNA expression is a potential prognostic biomarker in acute myeloid leukemia.Systematic Functional Characterization of Resistance to PI3K Inhibition in Breast Cancer.The PIM family of oncoproteins: small kinases with huge implications in myeloid leukemogenesis and as therapeutic targets.The Novel PIM1 Inhibitor NMS-P645 Reverses PIM1-Dependent Effects on TMPRSS2/ERG Positive Prostate Cancer Cells And Shows Anti-Proliferative Activity in Combination with PI3K Inhibition.Rational cotargeting of Pim-1 and Akt in prostate cancer.Cell surface GRP78 promotes tumor cell histone acetylation through metabolic reprogramming: a mechanism which modulates the Warburg effect.SOCS1 inhibits migration and invasion of prostate cancer cells, attenuates tumor growth and modulates the tumor stroma.Preclinical characterization of INCB053914, a novel pan-PIM kinase inhibitor, alone and in combination with anticancer agents, in models of hematologic malignancies.Age-related changes in rat prostate tissue; perspective of protein oxidation
P2860
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P2860
Elevation of receptor tyrosine kinases by small molecule AKT inhibitors in prostate cancer is mediated by Pim-1.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Elevation of receptor tyrosine ...... e cancer is mediated by Pim-1.
@en
Elevation of receptor tyrosine ...... e cancer is mediated by Pim-1.
@nl
type
label
Elevation of receptor tyrosine ...... e cancer is mediated by Pim-1.
@en
Elevation of receptor tyrosine ...... e cancer is mediated by Pim-1.
@nl
prefLabel
Elevation of receptor tyrosine ...... e cancer is mediated by Pim-1.
@en
Elevation of receptor tyrosine ...... e cancer is mediated by Pim-1.
@nl
P2093
P2860
P1433
P1476
Elevation of receptor tyrosine ...... e cancer is mediated by Pim-1.
@en
P2093
Andrew S Kraft
Sandeep Mahajan
Wenxue Wang
P2860
P304
P356
10.1158/0008-5472.CAN-12-4619
P407
P577
2013-04-12T00:00:00Z