Reactive oxygen species-mediated activation of the Akt/ASK1/p38 signaling cascade and p21(Cip1) downregulation are required for shikonin-induced apoptosis.
about
Comparative effects of 4-phenyl-3-butenoic acid and vorinostat on cell growth and signalingFenofibrate induces apoptosis of triple-negative breast cancer cells via activation of NF-κB pathwayCytoplasmic localization of p21 protects trophoblast giant cells from DNA damage induced apoptosis.In vitro induction of erythrocyte phosphatidylserine translocation by the natural naphthoquinone shikonin.Towards the small and the beautiful: a small dibromotyrosine derivative from Pseudoceratina sp. sponge exhibits potent apoptotic effect through targeting IKK/NFκB signaling pathway.Synergistic anti-tumour effects of tetrandrine and chloroquine combination therapy in human cancer: a potential antagonistic role for p21.MicroRNA-302 induces proliferation and inhibits oxidant-induced cell death in human adipose tissue-derived mesenchymal stem cellsThe role of the PI3K/Akt/mTOR signalling pathway in human cancers induced by infection with human papillomaviruses.Inhibition of c-MYC with involvement of ERK/JNK/MAPK and AKT pathways as a novel mechanism for shikonin and its derivatives in killing leukemia cells.Shikonin induces apoptosis of HaCaT cells via the mitochondrial, Erk and Akt pathways.Oxidative Stress Promotes Peroxiredoxin Hyperoxidation and Attenuates Pro-survival Signaling in Aging Chondrocytes.Inverse agonist of estrogen-related receptor α suppresses the growth of triple negative breast cancer cells through ROS generation and interaction with multiple cell signaling pathwaysShikonin potentiates the effect of arsenic trioxide against human hepatocellular carcinoma in vitro and in vivo.Functional analyses of major cancer-related signaling pathways in Alzheimer's disease etiology.Metabolic profiling study of shikonin's cytotoxic activity in the Huh7 human hepatoma cell line.Inhibition of heme oxygenase-1 enhances the chemosensitivity of laryngeal squamous cell cancer Hep-2 cells to cisplatin.Redox regulation of autophagy in skeletal muscle.Shikonin selectively induces apoptosis in human prostate cancer cells through the endoplasmic reticulum stress and mitochondrial apoptotic pathway.Shikonin, dually functions as a proteasome inhibitor and a necroptosis inducer in multiple myeloma cells.Microcystin-LR-caused ROS generation involved in p38 activation and tau hyperphosphorylation in neuroendocrine (PC12) cells.Isorhynchophylline Attenuates MPP+-Induced Apoptosis Through Endoplasmic Reticulum Stress- and Mitochondria-Dependent Pathways in PC12 Cells: Involvement of Antioxidant Activity.Necroptosis promotes autophagy-dependent upregulation of DAMP and results in immunosurveillance.Shikonin inhibits TNF-α-induced growth and invasion of rat aortic vascular smooth muscle cells.
P2860
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P2860
Reactive oxygen species-mediated activation of the Akt/ASK1/p38 signaling cascade and p21(Cip1) downregulation are required for shikonin-induced apoptosis.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Reactive oxygen species-mediated activation of the Akt/ASK1/p38 signaling cascade and p21
@nl
Reactive oxygen species-mediat ...... or shikonin-induced apoptosis.
@en
type
label
Reactive oxygen species-mediated activation of the Akt/ASK1/p38 signaling cascade and p21
@nl
Reactive oxygen species-mediat ...... or shikonin-induced apoptosis.
@en
prefLabel
Reactive oxygen species-mediated activation of the Akt/ASK1/p38 signaling cascade and p21
@nl
Reactive oxygen species-mediat ...... or shikonin-induced apoptosis.
@en
P2093
P2860
P1433
P1476
Reactive oxygen species-mediat ...... or shikonin-induced apoptosis.
@en
P2093
Cho-Rock Jung
Dong-Su Im
Jeong-Hae Choi
Kyeong Lee
Kyung-Bin Song
Kyung-Sook Chung
Mi-Lang Kyun
Yong Sung Kim
P2860
P2888
P304
P356
10.1007/S10495-013-0835-5
P577
2013-07-01T00:00:00Z