Colloidal aggregation causes inhibition of G protein-coupled receptors.
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Can Invalid Bioactives Undermine Natural Product-Based Drug Discovery?A brief review of recent Charcot-Marie-Tooth research and prioritiesIn Vitro and In Vivo Characterization of the Alkaloid NuciferineDocking Screens for Novel Ligands Conferring New Biology.Quantification of frequent-hitter behavior based on historical high-throughput screening data.Serendipitous discovery of light-induced (In Situ) formation of an Azo-bridged dimeric sulfonated naphthol as a potent PTP1B inhibitor.Host-directed antimicrobial drugs with broad-spectrum efficacy against intracellular bacterial pathogens.The promise and peril of chemical probes.Stratified high-throughput screening sets enable flexible screening strategies from a single plated collection.Applications of Biophysics in High-Throughput Screening Hit Validation.Colloidal aggregation and the in vitro activity of traditional Chinese medicinesNon-stoichiometric inhibition in integrated lead finding - a literature review.Identification of Novel Smoothened Ligands Using Structure-Based Docking.Phantom PAINS: Problems with the Utility of Alerts for Pan-Assay INterference CompoundS.Open Source Bayesian Models. 3. Composite Models for Prediction of Binned ResponsesStable Colloidal Drug Aggregates Catch and Release Active Enzymes.Imaging self-assembly dependent spatial distribution of small molecules in a cellular environment.TLR4-dependent internalization of CX3CR1 aggravates sepsis-induced immunoparalysisColloidal drug formulations can explain "bell-shaped" concentration-response curves.Development of a pharmacophore for cruzain using oxadiazoles as virtual molecular probes: quantitative structure-activity relationship studies.Integrated Computational Approach for Virtual Hit Identification against Ebola Viral Proteins VP35 and VP40.Enzyme-Regulated Supramolecular Assemblies of Cholesterol Conjugates against Drug-Resistant Ovarian Cancer Cells.Leveraging Colloidal Aggregation for Drug-Rich Nanoparticle Formulations.An Aggregation Advisor for Ligand Discovery.Orphan receptor ligand discovery by pickpocketing pharmacological neighbors.Inhibition of soluble guanylyl cyclase by small molecules targeting the catalytic domainA New Spin on Antibody-Drug Conjugates: Trastuzumab-Fulvestrant Colloidal Drug Aggregates Target HER2-Positive Cells.Comparative Molecular Dynamics Simulation of Aggregating and Non-Aggregating Inhibitor Solutions: Understanding the Molecular Basis of Promiscuity.The Ecstasy and Agony of Assay Interference CompoundsThe Ecstasy and Agony of Assay Interference Compounds
P2860
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P2860
Colloidal aggregation causes inhibition of G protein-coupled receptors.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Colloidal aggregation causes inhibition of G protein-coupled receptors.
@en
Colloidal aggregation causes inhibition of G protein-coupled receptors.
@nl
type
label
Colloidal aggregation causes inhibition of G protein-coupled receptors.
@en
Colloidal aggregation causes inhibition of G protein-coupled receptors.
@nl
prefLabel
Colloidal aggregation causes inhibition of G protein-coupled receptors.
@en
Colloidal aggregation causes inhibition of G protein-coupled receptors.
@nl
P2093
P2860
P356
P1476
Colloidal aggregation causes inhibition of G protein-coupled receptors.
@en
P2093
Allison K Doak
Brian K Shoichet
Bryan L Roth
Maria F Sassano
P2860
P304
P356
10.1021/JM301749Y
P407
P577
2013-03-12T00:00:00Z