Colloidal aggregation causes inhibition of G protein-coupled receptors. - Wikidata - awgldk - TriplyDB

Colloidal aggregation causes inhibition of G protein-coupled receptors.

Colloidal aggregation causes inhibition of G protein-coupled receptors.

http://www.wikidata.org/entity/Q39189071

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Can Invalid Bioactives Undermine Natural Product-Based Drug Discovery?A brief review of recent Charcot-Marie-Tooth research and priorities In Vitro and In Vivo Characterization of the Alkaloid Nuciferine Docking Screens for Novel Ligands Conferring New Biology.Quantification of frequent-hitter behavior based on historical high-throughput screening data.Serendipitous discovery of light-induced (In Situ) formation of an Azo-bridged dimeric sulfonated naphthol as a potent PTP1B inhibitor.Host-directed antimicrobial drugs with broad-spectrum efficacy against intracellular bacterial pathogens.The promise and peril of chemical probes.Stratified high-throughput screening sets enable flexible screening strategies from a single plated collection.Applications of Biophysics in High-Throughput Screening Hit Validation.Colloidal aggregation and the in vitro activity of traditional Chinese medicines Non-stoichiometric inhibition in integrated lead finding - a literature review.Identification of Novel Smoothened Ligands Using Structure-Based Docking.Phantom PAINS: Problems with the Utility of Alerts for Pan-Assay INterference CompoundS.Open Source Bayesian Models. 3. Composite Models for Prediction of Binned Responses Stable Colloidal Drug Aggregates Catch and Release Active Enzymes.Imaging self-assembly dependent spatial distribution of small molecules in a cellular environment.TLR4-dependent internalization of CX3CR1 aggravates sepsis-induced immunoparalysis Colloidal drug formulations can explain "bell-shaped" concentration-response curves.Development of a pharmacophore for cruzain using oxadiazoles as virtual molecular probes: quantitative structure-activity relationship studies.Integrated Computational Approach for Virtual Hit Identification against Ebola Viral Proteins VP35 and VP40.Enzyme-Regulated Supramolecular Assemblies of Cholesterol Conjugates against Drug-Resistant Ovarian Cancer Cells.Leveraging Colloidal Aggregation for Drug-Rich Nanoparticle Formulations.An Aggregation Advisor for Ligand Discovery.Orphan receptor ligand discovery by pickpocketing pharmacological neighbors.Inhibition of soluble guanylyl cyclase by small molecules targeting the catalytic domain A New Spin on Antibody-Drug Conjugates: Trastuzumab-Fulvestrant Colloidal Drug Aggregates Target HER2-Positive Cells.Comparative Molecular Dynamics Simulation of Aggregating and Non-Aggregating Inhibitor Solutions: Understanding the Molecular Basis of Promiscuity.The Ecstasy and Agony of Assay Interference Compounds The Ecstasy and Agony of Assay Interference Compounds

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P2860

Colloidal aggregation causes inhibition of G protein-coupled receptors.

http://www.wikidata.org/entity/Q39189071

description

2013 nî lūn-bûn

@nan

2013年の論文

@ja

2013年論文

@yue

2013年論文

@zh-hant

2013年論文

@zh-hk

2013年論文

@zh-mo

2013年論文

@zh-tw

2013年论文

@wuu

2013年论文

@zh

2013年论文

@zh-cn

name

Colloidal aggregation causes inhibition of G protein-coupled receptors.

@en

Colloidal aggregation causes inhibition of G protein-coupled receptors.

@nl

type

label

Colloidal aggregation causes inhibition of G protein-coupled receptors.

@en

Colloidal aggregation causes inhibition of G protein-coupled receptors.

@nl

prefLabel

Colloidal aggregation causes inhibition of G protein-coupled receptors.

@en

Colloidal aggregation causes inhibition of G protein-coupled receptors.

@nl

P1433

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Journal of Medicinal Chemistry

P1476

Colloidal aggregation causes inhibition of G protein-coupled receptors.

@en

P2093

Allison K Doak

http://www.w3.org/2001/XMLSchema#string

Brian K Shoichet

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Bryan L Roth

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Maria F Sassano

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P2860

A Common Mechanism Underlying Promiscuous Inhibitors from Virtual and High-Throughput Screening

The genetic design of signaling cascades to record receptor activation

Comprehensive Mechanistic Analysis of Hits from High-Throughput and Docking Screens against β-Lactamase

ChEMBL: a large-scale bioactivity database for drug discovery

Dissecting cellular processes using small molecules: identification of colchicine-like, taxol-like and other small molecules that perturb mitosis

New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays

Colloid formation by drugs in simulated intestinal fluid.

Quantitative analyses of aggregation, autofluorescence, and reactivity artifacts in a screen for inhibitors of a thiol protease

Druggability indices for protein targets derived from NMR-based screening data.

Identification of novel species-selective agonists of the G-protein-coupled receptor GPR35 that promote recruitment of β-arrestin-2 and activate Gα13.

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2406-2414

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scholarly article

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10.1021/JM301749Y

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6

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56

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2013-03-12T00:00:00Z

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235727499

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23437772

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G protein-coupled receptor

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3613083

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