KSR as a therapeutic target for Ras-dependent cancers.

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KSR as a therapeutic target for Ras-dependent cancers.

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2017 nî lūn-bûn

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2017年の論文

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2017年論文

@yue

2017年論文

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2017年論文

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2017年論文

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2017年論文

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2017年论文

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2017年论文

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2017年论文

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KSR as a therapeutic target for Ras-dependent cancers.

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KSR as a therapeutic target for Ras-dependent cancers.

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KSR as a therapeutic target for Ras-dependent cancers.

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KSR as a therapeutic target for Ras-dependent cancers.

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KSR as a therapeutic target for Ras-dependent cancers.

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KSR as a therapeutic target for Ras-dependent cancers.

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P1476

KSR as a therapeutic target for Ras-dependent cancers

@en

P2093

Danielle E Frodyma

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Robert E Lewis

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P2860

Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP

KSR, a novel protein kinase required for RAS signal transduction

Complexity in KSR function revealed by Raf inhibitor and KSR structure studies

Solution structure and functional analysis of the cysteine-rich C1 domain of kinase suppressor of Ras (KSR)

A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK

Inhibitors that stabilize a closed RAF kinase domain conformation induce dimerization

Small molecule stabilization of the KSR inactive state antagonizes oncogenic Ras signalling

A dimerization-dependent mechanism drives RAF catalytic activation.

Proteomic characterization of the dynamic KSR-2 interactome, a signaling scaffold complex in MAPK pathway

Murine Ksr interacts with MEK and inhibits Ras-induced transformation

P304

499-509

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P31

scholarly article

P356

10.1080/14728222.2017.1311325

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P407

English

P433

http://www.w3.org/2001/XMLSchema#string

P478

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P50

Kurt Fisher

Beth K Neilsen

P577

2017-04-07T00:00:00Z

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P698

28333549

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P932

5490495

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