Enzymatic methyl transfer: role of an active site residue in generating active site compaction that correlates with catalytic efficiency.
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Extremely Elevated Room-Temperature Kinetic Isotope Effects Quantify the Critical Role of Barrier Width in Enzymatic C–H ActivationHow Large Should the QM Region Be in QM/MM Calculations? The Case of Catechol O-MethyltransferasePerspective: Defining and quantifying the role of dynamics in enzyme catalysisIntegration of Tmc1/2 into the mechanotransduction complex in zebrafish hair cells is regulated by Transmembrane O-methyltransferase (Tomt).The murine catecholamine methyltransferase mTOMT is essential for mechanotransduction by cochlear hair cells.Convergent Mechanistic Features between the Structurally Diverse N- and O-Methyltransferases: Glycine N-Methyltransferase and Catechol O-Methyltransferase.Studying the role of protein dynamics in an SN2 enzyme reaction using free-energy surfaces and solvent coordinates.Picosecond-resolved fluorescent probes at functionally distinct tryptophans within a thermophilic alcohol dehydrogenase: relationship of temperature-dependent changes in fluorescence to catalysis.Hydrogen tunneling links protein dynamics to enzyme catalysisHigh-performance liquid chromatography separation of the (S,S)- and (R,S)-forms of S-adenosyl-L-methionineMethionine sulfoxide reductase regulates brain catechol-O-methyl transferase activity.Mediation of donor-acceptor distance in an enzymatic methyl transfer reactionComputational Investigation of the Interplay of Substrate Positioning and Reactivity in Catechol O-Methyltransferase.Kinetic isotope effects reveal early transition state of protein lysine methyltransferase SET8.Transition state for the NSD2-catalyzed methylation of histone H3 lysine 36Heavy-enzyme kinetic isotope effects on proton transfer in alanine racemase.Human DNMT1 transition state structure.S-adenosyl-methionine-dependent methyltransferases: highly versatile enzymes in biocatalysis, biosynthesis and other biotechnological applications.High-resolution studies of hydride transfer in the ferredoxin:NADP+ reductase superfamily.Influence of Equatorial CH⋅⋅⋅O Interactions on Secondary Kinetic Isotope Effects for Methyl TransferEffects of Active-Site Modification and Quaternary Structure on the Regioselectivity of Catechol-O-Methyltransferase.Induced fit of the peptidyl-transferase center of the ribosome and conformational freedom of the esterified amino acids.Kinetic Isotope Effects and Transition State Structure for Human Phenylethanolamine N-Methyltransferase.Methyltransferases do not work by compression, cratic, or desolvation effects, but by electrostatic preorganization.Are there dynamical effects in enzyme catalysis? Some thoughts concerning the enzymatic chemical step.Multistructural microiteration technique for geometry optimization and reaction path calculation in large systems.13C ENDOR Spectroscopy of Lipoxygenase-Substrate Complexes Reveals the Structural Basis for C-H Activation by Tunneling.Engineered control of enzyme structural dynamics and function.Functional and structural characterisation of a bacterial O-methyltransferase and factors determining regioselectivity.Exploring the origin of the catalytic power and product specificity of SET domain protein methyltransferase.
P2860
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P2860
Enzymatic methyl transfer: role of an active site residue in generating active site compaction that correlates with catalytic efficiency.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Enzymatic methyl transfer: rol ...... tes with catalytic efficiency.
@en
Enzymatic methyl transfer: rol ...... tes with catalytic efficiency.
@nl
type
label
Enzymatic methyl transfer: rol ...... tes with catalytic efficiency.
@en
Enzymatic methyl transfer: rol ...... tes with catalytic efficiency.
@nl
prefLabel
Enzymatic methyl transfer: rol ...... tes with catalytic efficiency.
@en
Enzymatic methyl transfer: rol ...... tes with catalytic efficiency.
@nl
P2860
P356
P1476
Enzymatic methyl transfer: rol ...... ates with catalytic efficiency
@en
P2093
Judith P Klinman
P2860
P304
17134-17137
P356
10.1021/JA207467D
P407
P577
2011-10-10T00:00:00Z