A histone deacetylase inhibitor, largazole, decreases liver fibrosis and angiogenesis by inhibiting transforming growth factor-β and vascular endothelial growth factor signalling.
about
Dysregulation of histone acetyltransferases and deacetylases in cardiovascular diseasesCHOP mediates ASPP2-induced autophagic apoptosis in hepatoma cells by releasing Beclin-1 from Bcl-2 and inducing nuclear translocation of Bcl-2Evaluation of class I HDAC isoform selectivity of largazole analoguesSynthesis and biological evaluation of largazole analogues with modified surface recognition cap groupsA new histone deacetylase inhibitor improves liver fibrosis in BDL rats through suppression of hepatic stellate cells.Biological targets and mechanisms of action of natural products from marine cyanobacteria.Activation of Mir-29a in Activated Hepatic Stellate Cells Modulates Its Profibrogenic Phenotype through Inhibition of Histone Deacetylases 4.Combination of sorafenib and gadolinium chloride (GdCl3) attenuates dimethylnitrosamine(DMN)-induced liver fibrosis in ratsDNA methylation profiling identifies novel markers of progression in hepatitis B-related chronic liver disease.Phosphorylated AKT inhibits the apoptosis induced by DRAM-mediated mitophagy in hepatocellular carcinoma by preventing the translocation of DRAM to mitochondria.Largazole pharmacokinetics in rats by LC-MS/MS.Natural products as zinc-dependent histone deacetylase inhibitors.S-Adenosylmethionine suppresses the expression of Smad3/4 in activated human hepatic stellate cells via Rac1 promoter methylationEpigenetic control of the tumor microenvironment.Angiogenesis and Fibrogenesis in Chronic Liver Diseases.Epigenetics and Liver Fibrosis.Molecular mechanisms of suberoylanilide hydroxamic acid in the inhibition of TGF-β1-mediated canine corneal fibrosis.A Proof-of-Concept for Epigenetic Therapy of Tissue Fibrosis: Inhibition of Liver Fibrosis Progression by 3-Deazaneplanocin A.Comparison of bone marrow-vs. adipose tissue-derived mesenchymal stem cells for attenuating liver fibrosis.Largazole Analogues Embodying Radical Changes in the Depsipeptide Ring: Development of a More Selective and Highly Potent Analogue.In vitro differentiated hepatic oval-like cells enhance hepatic regeneration in CCl4 -induced hepatic injury.Dihydroartemisinin prevents liver fibrosis in bile duct ligated rats by inducing hepatic stellate cell apoptosis through modulating the PI3K/Akt pathway.Epigenetic Regulation of Myofibroblast Phenotypes in FibrosisAntiangiogenic therapy for portal hypertension in liver cirrhosis: Current progress and perspectives
P2860
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P2860
A histone deacetylase inhibitor, largazole, decreases liver fibrosis and angiogenesis by inhibiting transforming growth factor-β and vascular endothelial growth factor signalling.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
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2012年學術文章
@zh-hant
name
A histone deacetylase inhibito ...... lial growth factor signalling.
@en
A histone deacetylase inhibito ...... lial growth factor signalling.
@nl
type
label
A histone deacetylase inhibito ...... lial growth factor signalling.
@en
A histone deacetylase inhibito ...... lial growth factor signalling.
@nl
prefLabel
A histone deacetylase inhibito ...... lial growth factor signalling.
@en
A histone deacetylase inhibito ...... lial growth factor signalling.
@nl
P2093
P2860
P356
P1433
P1476
A histone deacetylase inhibito ...... lial growth factor signalling.
@en
P2093
Eric L Lui
Jianing Wang
Scott L Friedman
Shoubin Tang
Shuqin Kwong
Shuyan Zhou
P2860
P304
P356
10.1111/LIV.12034
P577
2012-12-26T00:00:00Z