Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-I.
about
The Janus kinases (Jaks)Etk, a Btk family tyrosine kinase, mediates cellular transformation by linking Src to STAT3 activation.A gain-of-function mutation in STAT6Physical and functional interactions between STAT3 and Kaposi's sarcoma-associated herpesvirus-encoded LANACloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cellsInteraction between Sam68 and Src family tyrosine kinases, Fyn and Lck, in T cell receptor signalingThe SH2 domains of Stat1 and Stat2 mediate multiple interactions in the transduction of IFN-alpha signalsProtein kinase PKR is required for platelet-derived growth factor signaling of c-fos gene expression via Erks and Stat3.Different interleukin 2 receptor beta-chain tyrosines couple to at least two signaling pathways and synergistically mediate interleukin 2-induced proliferationJakinibs: a new class of kinase inhibitors in cancer and autoimmune diseaseThioredoxin-binding protein-2 (TBP-2/VDUP1/TXNIP) regulates T-cell sensitivity to glucocorticoid during HTLV-I-induced transformationSTAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylationActivation and association of Stat3 with Src in v-Src-transformed cell linesSignal transducers and activators of transcription as regulators of growth, apoptosis and breast development.Role of Tax protein in human T-cell leukemia virus type-I leukemogenicityHTLV-1/-2 and HIV-1 co-infections: retroviral interference on host immune statusHuman T-cell leukemia virus type 1 blunts signaling by interferon alphaThe human homologue of the yeast proteins Skb1 and Hsl7p interacts with Jak kinases and contains protein methyltransferase activity.Cytosolic tyrosine dephosphorylation of STAT5. Potential role of SHP-2 in STAT5 regulationThe JAK-STAT transcriptional regulator, STAT-5, activates the ATM DNA damage pathway to induce HPV 31 genome amplification upon epithelial differentiationSTATs in cancer inflammation and immunity: a leading role for STAT3Proliferation response to interleukin-2 and Jak/Stat activation of T cells immortalized by human T-cell lymphotropic virus type 1 is independent of open reading frame I expressionThe Lck binding domain of herpesvirus saimiri tip-484 constitutively activates Lck and STAT3 in T cells.STAT6 expression in glioblastoma promotes invasive growthRequirement for Ras/Rac1-mediated p38 and c-Jun N-terminal kinase signaling in Stat3 transcriptional activity induced by the Src oncoprotein.Molecular biology and pathogenesis of the human T-cell leukaemia/lymphotropic virus Type-1 (HTLV-1).IL-2 independent transformation of a unique human T cell line, TY8-3, and its subclones by HTLV-I and -II.Constitutive activation of JAK-STAT3 signaling by BRCA1 in human prostate cancer cells.Identification of human kinases involved in hepatitis C virus replication by small interference RNA library screening.Preclinical characterization of signal transducer and activator of transcription 3 small molecule inhibitors for primary and metastatic brain cancer therapyMechanisms of T-cell activation by human T-cell lymphotropic virus type I.Preexisting infection with human T-cell lymphotropic virus type 2 neither exacerbates nor attenuates simian immunodeficiency virus SIVmac251 infection in macaques.STAT signaling in the pathogenesis and treatment of cancerProliferation of adult T cell leukemia/lymphoma cells is associated with the constitutive activation of JAK/STAT proteinsHTLV-I Tax-dependent and -independent events associated with immortalization of human primary T lymphocytes.Erythropoietin and Friend virus gp55 activate different JAK/STAT pathways through the erythropoietin receptor in erythroid cellsHuman and simian T-cell leukemia viruses type 2 (HTLV-2 and STLV-2(pan-p)) transform T cells independently of Jak/STAT activation.Human T-cell lymphotropic/leukemia virus type 1 Tax abrogates p53-induced cell cycle arrest and apoptosis through its CREB/ATF functional domain.Stat3 activation is required for cellular transformation by v-src.Human T-cell leukemia virus type 2 tax mutants that selectively abrogate NFkappaB or CREB/ATF activation fail to transform primary human T cells.
P2860
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P2860
Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-I.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年学术文章
@wuu
1995年学术文章
@zh-cn
1995年学术文章
@zh-hans
1995年学术文章
@zh-my
1995年学术文章
@zh-sg
1995年學術文章
@yue
1995年學術文章
@zh
1995年學術文章
@zh-hant
name
Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-I.
@en
Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-I.
@nl
type
label
Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-I.
@en
Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-I.
@nl
prefLabel
Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-I.
@en
Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-I.
@nl
P2093
P356
P1433
P1476
Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-I.
@en
P2093
A Cereseto
G Franchini
J C Mulloy
J J O'Shea
T S Migone
W J Leonard
P356
10.1126/SCIENCE.7604283
P407
P577
1995-07-01T00:00:00Z