RiVax, a recombinant ricin subunit vaccine, protects mice against ricin delivered by gavage or aerosol - Wikidata - awgldk - TriplyDB

RiVax, a recombinant ricin subunit vaccine, protects mice against ricin delivered by gavage or aerosol

RiVax, a recombinant ricin subunit vaccine, protects mice against ricin delivered by gavage or aerosol

http://www.wikidata.org/entity/Q39252241

about

Plant-produced candidate countermeasures against emerging and reemerging infections and bioterror agents Structure of RiVax: a recombinant ricin vaccine Disruption of the Putative Vascular Leak Peptide Sequence in the Stabilized Ricin Vaccine Candidate RTA1-33/44-198 Principles of antidote pharmacology: an update on prophylaxis, post-exposure treatment recommendations and research initiatives for biological agents Novel Ricin Subunit Antigens With Enhanced Capacity to Elicit Toxin-Neutralizing Antibody Responses in Mice.Ricin A-chain requires c-Jun N-terminal kinase to induce apoptosis in nontransformed epithelial cells.Isolation of a human-like antibody fragment (scFv) that neutralizes ricin biological activity.A monoclonal immunoglobulin G antibody directed against an immunodominant linear epitope on the ricin A chain confers systemic and mucosal immunity to ricin.Chimeric plantibody passively protects mice against aerosolized ricin challenge.A lyophilized formulation of RiVax, a recombinant ricin subunit vaccine, retains immunogenicity.Neutralising antibodies against ricin toxin.Intradermal administration of RiVax protects mice from mucosal and systemic ricin intoxication Folding domains within the ricin toxin A subunit as targets of protective antibodies BiP negatively affects ricin transport.Vaccine-induced intestinal immunity to ricin toxin in the absence of secretory IgA.Combination of two candidate subunit vaccine antigens elicits protective immunity to ricin and anthrax toxin in mice Ricin crosses polarized human intestinal cells and intestines of ricin-gavaged mice without evident damage and then disseminates to mouse kidneys Mechanistic insights into the neutralization of cytotoxic abrin by the monoclonal antibody D6F10.Animal models of ricin toxicosis Thermostable ricin vaccine protects rhesus macaques against aerosolized ricin: Epitope-specific neutralizing antibodies correlate with protection.Protective immunity to ricin toxin conferred by antibodies against the toxin's binding subunit (RTB).Passive and active vaccination strategies to prevent ricin poisoning.Ricinus communis intoxications in human and veterinary medicine-a summary of real cases.Immunity to ricin: fundamental insights into toxin-antibody interactions.Strong protection against ricin challenge induced by a novel modified ricin A-chain protein in mouse model.Unraveling the Roots of Selectivity of Peptide Affinity Reagents for Structurally Similar Ribosomal Inactivating Protein Derivatives.Comparative Adjuvant Effects of Type II Heat-Labile Enterotoxins in Combination with Two Different Candidate Ricin Toxin Vaccine Antigens.A relatively low level of ribosome depurination by mutant forms of ricin toxin A chain can trigger protein synthesis inhibition, cell signaling and apoptosis in mammalian cells.Neutralizing Monoclonal Antibodies against Disparate Epitopes on Ricin Toxin's Enzymatic Subunit Interfere with Intracellular Toxin Transport.Comparative efficacy of two leading candidate ricin toxin a subunit vaccines in mice.A recombinant chimeric protein containing B chains of ricin and abrin is an effective vaccine candidate.LT-IIb(T13I), a non-toxic type II heat-labile enterotoxin, augments the capacity of a ricin toxin subunit vaccine to evoke neutralizing antibodies and protective immunity Activation of the cholinergic antiinflammatory pathway reduces ricin-induced mortality and organ failure in mice.Recent advances in the development of vaccines against ricin.Structural insights into the neutralization mechanism of monoclonal antibody 6C2 against ricin.Truncated abrin A chain expressed in Escherichia coli: a promising vaccine candidate.Stabilization of a recombinant ricin toxin A subunit vaccine through lyophilization.Absorption, distribution and pathological injury in mice due to ricin poisoning via the alimentary pathway Inhibitors of the cellular trafficking of ricin.Toxicity of ricin A chain is reduced in mammalian cells by inhibiting its interaction with the ribosome.

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RiVax, a recombinant ricin subunit vaccine, protects mice against ricin delivered by gavage or aerosol

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Ellen S Vitetta

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P2860

Impact of cethromycin (ABT-773) therapy on microbiological, histologic, immunologic, and respiratory indices in a murine model of Mycoplasma pneumoniae lower respiratory infection.

Chemical construction of immunotoxins.

A pilot clinical trial of a recombinant ricin vaccine in normal humans.

Ricin poisoning: a comprehensive review.

Intrapulmonary delivery of ricin at high dosage triggers a systemic inflammatory response and glomerular damage.

Evidence for widespread epithelial damage and coincident production of monocyte chemotactic protein 1 in a murine model of intestinal ricin intoxication

Ricin: mechanism of toxicity, clinical manifestations, and vaccine development. A review.

Humoral immune defense (antibodies): recent advances.

Interspecies comparisons of particle deposition and mucociliary clearance in tracheobronchial airways.

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