Pluripotent stem cells escape from senescence-associated DNA methylation changes. - Wikidata - awgldk - TriplyDB

Pluripotent stem cells escape from senescence-associated DNA methylation changes.

Pluripotent stem cells escape from senescence-associated DNA methylation changes.

http://www.wikidata.org/entity/Q39256627

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Aging of blood can be tracked by DNA methylation changes at just three CpG sites Radio-resistant mesenchymal stem cells: mechanisms of resistance and potential implications for the clinic To clone or not to clone? Induced pluripotent stem cells can be generated in bulk culture In silico approaches and the role of ontologies in aging research The polycomb protein Ezh2 impacts on induced pluripotent stem cell generation.Immortalization of T-cells is accompanied by gradual changes in CpG methylation resulting in a profile resembling a subset of T-cell leukemias.Epigenetic clock analyses of cellular senescence and ageing TGF-beta1 does not induce senescence of multipotent mesenchymal stromal cells and has similar effects in early and late passages.The influence of physical and physiological cues on atomic force microscopy-based cell stiffness assessment.Proof of principle: quality control of therapeutic cell preparations using senescence-associated DNA-methylation changes.Replicative senescence is associated with nuclear reorganization and with DNA methylation at specific transcription factor binding sites TGF-β stimulation in human and murine cells reveals commonly affected biological processes and pathways at transcription level.Epigenetic Aging Signatures Are Coherently Modified in Cancer High cortisol in 5-year-old children causes loss of DNA methylation in SINE retrotransposons: a possible role for ZNF263 in stress-related diseases.HOTAIR and its surrogate DNA methylation signature indicate carboplatin resistance in ovarian cancer In Vitro Expansion of Bone Marrow Derived Mesenchymal Stem Cells Alters DNA Double Strand Break Repair of Etoposide Induced DNA Damage.Implications of long-term culture for mesenchymal stem cells: genetic defects or epigenetic regulation?The lncRNA HOTAIR impacts on mesenchymal stem cells via triple helix formation.A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects.Cross-sectional and longitudinal changes in DNA methylation with age: an epigenome-wide analysis revealing over 60 novel age-associated CpG sites.Influence of maternal obesity, diet and exercise on epigenetic regulation of adipocytes.Do age-associated DNA methylation changes increase the risk of malignant transformation?Epigenetic Classification of Human Mesenchymal Stromal Cells.Premature aging/senescence in cancer cells facing therapy: good or bad?Epigenetic biomarker to support classification into pluripotent and non-pluripotent cells.Polycomb protein EED is required for silencing of pluripotency genes upon ESC differentiation.Human Platelet Lysate versus Fetal Calf Serum: These Supplements Do Not Select for Different Mesenchymal Stromal Cells.Methylome Analysis of Human Bone Marrow MSCs Reveals Extensive Age- and Culture-Induced Changes at Distal Regulatory Elements.Senescence-associated DNA methylation is stochastically acquired in subpopulations of mesenchymal stem cells.Epigenetic rejuvenation of mesenchymal stromal cells derived from induced pluripotent stem cells Hematopoietic stem and progenitor cells acquire distinct DNA-hypermethylation during in vitro culture.Primary Osteoporosis Is Not Reflected by Disease-Specific DNA Methylation or Accelerated Epigenetic Age in Blood.Ubiquitin C decrement plays a pivotal role in replicative senescence of bone marrow mesenchymal stromal cells.Age Is Relative-Impact of Donor Age on Induced Pluripotent Stem Cell-Derived Cell Functionality.DNA Methylation Patterns Separate Senescence from Transformation Potential and Indicate Cancer Risk.Epigenetic regulation in cell senescence.Epigenetic quality check - how good are your mesenchymal stromal cells?DNA-methylation changes in replicative senescence and aging: two sides of the same coin?Age-related DNA methylation changes are tissue-specific with ELOVL2 promoter methylation as exception.Genomic Instabilities, Cellular Senescence, and Aging: In Vitro, In Vivo and Aging-Like Human Syndromes.

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Pluripotent stem cells escape from senescence-associated DNA methylation changes.

http://www.wikidata.org/entity/Q39256627

description

2012 nî lūn-bûn

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年學術文章

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2012年學術文章

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2012年學術文章

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name

Pluripotent stem cells escape from senescence-associated DNA methylation changes.

@en

Pluripotent stem cells escape from senescence-associated DNA methylation changes.

@nl

type

label

Pluripotent stem cells escape from senescence-associated DNA methylation changes.

@en

Pluripotent stem cells escape from senescence-associated DNA methylation changes.

@nl

prefLabel

Pluripotent stem cells escape from senescence-associated DNA methylation changes.

@en

Pluripotent stem cells escape from senescence-associated DNA methylation changes.

@nl

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Genome Research

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Pluripotent stem cells escape from senescence-associated DNA methylation changes.

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Bertram Opalka

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Carmen M Koch

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Gudrun Walenda

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Kaifeng Shao

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Kristina Reck

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Martin Zenke

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Patrick Ziegler

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Sylvia Joussen

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Tim Brümmendorf

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Tobias May

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P2860

Double strand breaks can initiate gene silencing and SIRT1-dependent onset of DNA methylation in an exogenous promoter CpG island

A novel role for high-mobility group a proteins in cellular senescence and heterochromatin formation

Extension of life-span by introduction of telomerase into normal human cells

DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts

Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts

Human DNA methylomes at base resolution show widespread epigenomic differences

Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a

Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs

Multilineage potential of adult human mesenchymal stem cells

Induction of pluripotent stem cells from adult human fibroblasts by defined factors

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248-259

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10.1101/GR.141945.112

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2

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23

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Wolfgang Wagner

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2012-10-18T00:00:00Z

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23080539

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DNA methylation

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3561866

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