Destabilization of ATP-sensitive potassium channel activity by novel KCNJ11 mutations identified in congenital hyperinsulinism.
about
Role of Hsp90 in biogenesis of the beta-cell ATP-sensitive potassium channel complexCharacterization and functional restoration of a potassium channel Kir6.2 pore mutation identified in congenital hyperinsulinismHuman K(ATP) channelopathies: diseases of metabolic homeostasis.Congenital hyperinsulinism and glucose hypersensitivity in homozygous and heterozygous carriers of Kir6.2 (KCNJ11) mutation V290M mutation: K(ATP) channel inactivation mechanism and clinical management.ATP modulates interaction of syntaxin-1A with sulfonylurea receptor 1 to regulate pancreatic beta-cell KATP channelsN-terminal transmembrane domain of SUR1 controls gating of Kir6.2 by modulating channel sensitivity to PIP2Syntaxin 1A regulates surface expression of beta-cell ATP-sensitive potassium channels.A Kir6.2 pore mutation causes inactivation of ATP-sensitive potassium channels by disrupting PIP2-dependent gating.Structurally distinct ligands rescue biogenesis defects of the KATP channel complex via a converging mechanism.Role of Derlin-1 protein in proteostasis regulation of ATP-sensitive potassium channels.Engineered interaction between SUR1 and Kir6.2 that enhances ATP sensitivity in KATP channels.KCNJ11 knockout morula re-engineered by stem cell diploid aggregation.Carbamazepine as a novel small molecule corrector of trafficking-impaired ATP-sensitive potassium channels identified in congenital hyperinsulinism.A mouse model of human hyperinsulinism produced by the E1506K mutation in the sulphonylurea receptor SUR1.Leptin regulates KATP channel trafficking in pancreatic β-cells by a signaling mechanism involving AMP-activated protein kinase (AMPK) and cAMP-dependent protein kinase (PKA).Pharmacological rescue of trafficking-impaired ATP-sensitive potassium channels.Molecular biology of K(ATP) channels and implications for health and disease.Channelopathies linked to plasma membrane phosphoinositides.The role of the KATP channel in glucose homeostasis in health and disease: more than meets the islet.Syntaxin-1A interacts with distinct domains within nucleotide-binding folds of sulfonylurea receptor 1 to inhibit beta-cell ATP-sensitive potassium channels.Control of Kir channel gating by cytoplasmic domain interface interactionsAnti-diabetic drug binding site in a mammalian KATP channel revealed by Cryo-EM.Methods for Characterizing Disease-Associated ATP-Sensitive Potassium Channel Mutations.Cryo-electron microscopy structures and progress toward a dynamic understanding of KATP channels.The role of KATP channels in cerebral ischemic stroke and diabetes.Genetic Testing of Maturity-Onset Diabetes of the Young Current Status and Future Perspectives.
P2860
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P2860
Destabilization of ATP-sensitive potassium channel activity by novel KCNJ11 mutations identified in congenital hyperinsulinism.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Destabilization of ATP-sensiti ...... in congenital hyperinsulinism.
@en
Destabilization of ATP-sensiti ...... in congenital hyperinsulinism.
@nl
type
label
Destabilization of ATP-sensiti ...... in congenital hyperinsulinism.
@en
Destabilization of ATP-sensiti ...... in congenital hyperinsulinism.
@nl
prefLabel
Destabilization of ATP-sensiti ...... in congenital hyperinsulinism.
@en
Destabilization of ATP-sensiti ...... in congenital hyperinsulinism.
@nl
P2093
P2860
P356
P1476
Destabilization of ATP-sensiti ...... in congenital hyperinsulinism.
@en
P2093
Arupa Ganguly
Courtney MacMullen
Fei-Fei Yan
Jeremy D Bushman
Sara Haidar
Show-Ling Shyng
Yu-Wen Lin
P2860
P304
P356
10.1074/JBC.M708798200
P407
P577
2008-02-04T00:00:00Z