Fundamental difference between the molecular interactions of agonists and antagonists with the beta-adrenergic receptor.
about
Ligand binding assays at equilibrium: validation and interpretationTemperature-induced changes in dissociation constants (KA) of agonists at cardiac beta-adrenoceptors determined by use of the irreversible antagonist Ro 03-7894Predicting novel binding modes of agonists to β adrenergic receptors using all-atom molecular dynamics simulationsPathway and mechanism of drug binding to G-protein-coupled receptors.A rhodopsin exhibiting binding ability to agonist all-trans-retinal.The effect of stereochemistry on the thermodynamic characteristics of the binding of fenoterol stereoisomers to the beta(2)-adrenoceptorBinding of inositol 1,4,5-trisphosphate (IP3) and adenophostin A to the N-terminal region of the IP3 receptor: thermodynamic analysis using fluorescence polarization with a novel IP3 receptor ligand.Analysis of protein-ligand interactions by fluorescence polarizationBiochemical, physiological, and pathological aspects of the peripheral benzodiazepine receptor.Agonist-induced conformational changes in the G-protein-coupling domain of the beta 2 adrenergic receptor.Differentiation of receptor subtypes by thermodynamic analysis: application to opioid delta receptors.Thermodynamics and docking of agonists to the β(2)-adrenoceptor determined using [(3)H](R,R')-4-methoxyfenoterol as the marker ligand.Trapping of the beta-adrenergic receptor in the hormone-induced state.Influence of the beta-adrenergic receptor concentration on functional coupling to the adenylate cyclase system.Inhibition of sequestration of human B2 bradykinin receptor by phenylarsine oxide or sucrose allows determination of a receptor affinity shift and ligand dissociation in intact cells.Thermodynamic analysis of ligands at cholecystokinin CCK2 receptors in rat cerebral cortex.Evidence that histamine homologues discriminate between H3-receptors in guinea-pig cerebral cortex and ileum longitudinal muscle myenteric plexusOn the 'micro'-pharmacodynamic and pharmacokinetic mechanisms that contribute to long-lasting drug action.Stereoselective binding of agonists to the β2-adrenergic receptor: insights into molecular details and thermodynamics from molecular dynamics simulations.Thermodynamic assessment of the stability of thrombin receptor antagonistic peptides in hydrophobic environments.Distinct platelet thromboxane A2/prostaglandin H2 receptor subtypes. A radioligand binding study of human plateletsOn the stability of nucleic acid structures in solution: enthalpy-entropy compensations, internal rotations and reversibility.Enthalpy-entropy relationship in drug-cholinoceptor interaction: a new approach.Histamine H3-receptor agonists and imidazole-based H3-receptor antagonists can be thermodynamically discriminated.The effects of temperature on the interactions between volatile general anaesthetics and a neuronal nicotinic acetylcholine receptorThermodynamically distinct high and low affinity states of the A(1) adenosine receptor induced by G protein coupling and guanine nucleotide ligation states of G proteins.Saturation assays of radioligand binding to receptors and their allosteric modulatory sites.Characterization of [3H]-imidazenil binding to rat brain membranesThermodynamic analysis of agonist and antagonist binding to the chicken brain melatonin receptor.Effects of temperature and ethanol on agonist and antagonist binding to rat heart muscarinic receptors in the absence and presence of GTP.Kinetics and thermodynamics of activation of pretreatment with guanosine 5'-[beta, gamma-imido]triphosphate of smooth-muscle adenylate cyclase.Thermodynamics of antagonist binding to rat muscarinic M2 receptors: antimuscarinics of the pridinol, sila-pridinol, diphenidol and sila-diphenidol type.Water accessibility to the binding cleft as a major switching factor from entropy-driven to enthalpy-driven binding of an alkyl group by synthetic receptors.Role of interfacial hydrophobic residues in the stabilization of the leucine zipper structures of the transcription factors c-Fos and c-Jun.Receptor binding at two different temperatures to discriminate agonist and antagonist behaviour of adenosine A1 receptor ligands in rat brain.Thermodynamic parameters of opioid binding in the presence and absence of G-protein coupling.Hippocampal and cerebellar beta-adrenergic receptors and adenylate cyclase are differentially altered by chronic ethanol ingestion.Analysis of hydrophobic interactions of antagonists with the beta2-adrenergic receptor.Effects of temperature and allosteric modulators on [3H] nitrendipine binding: methods for detecting potential Ca2+ channel blockers.Thermodynamic study of iodocyanopindolol beta-adrenoceptors interactions with rat lung and cerebral cortex.
P2860
Q24629851-7AAC60EC-BDAC-488B-B64D-A014C4DA197FQ28365782-449B3469-F092-43A0-9318-5A89196CFF7CQ28476703-317D254D-C20C-4832-A463-7AC204CCAF6DQ30503489-53E4CBDB-4B6F-4A11-AAA0-F0568375A281Q33772075-F0900F6E-45F1-45AC-A0C4-4F25D3A3BC83Q33773424-FF550CC4-E7D2-43EB-9454-158887136BE6Q33890836-8AD63C3F-094E-41E6-8525-92FE53A67921Q35177806-1973E93A-E727-447C-ADD8-2A9E86F17BC3Q35226963-6ABADB99-B73D-48B4-AC75-2C43276BC9F2Q35925395-C645C97D-DBE1-480A-BBC0-46D75ECB44ABQ35954096-188133FD-76D5-4669-92EA-C71DA4F684B6Q35996733-262253E0-235E-4E2E-A8AE-B6E9E688F65DQ37512819-40B08512-6558-4532-8767-5730DA37A482Q37560108-134D1DCE-7743-4F72-ADEA-13585B858225Q38335243-258DFF38-23A1-4DF6-A4BB-5DD0A8662FA5Q38505357-1C32F94F-5638-4449-85A6-AA0D8EE0C6BFQ38527186-936BBF87-A79E-4137-958E-402FEF964CAEQ38545579-24210A23-CEE5-497E-9E17-BC722A2BD4CFQ38880205-B00B1814-5F12-4957-8ECE-A3303E187E5BQ40205531-666FA554-9EDC-4F72-9716-B8D9311409A1Q40380526-831FBE03-F7A4-4E78-A078-0BD9F08D259AQ40406785-ECD27F2D-4D7B-44B9-B83F-3BA98FFDE68FQ41503963-EB3D3AD1-017C-4F48-AD4F-42A3BDFF82DDQ41587095-7505D855-8CCA-4984-BC10-211FC7FF35C4Q41986629-10ADD16F-4124-4603-A57F-FFC234740712Q42126950-01F6F9B2-0F84-47E7-85D2-1A0907D99452Q42168085-D591F0DE-9EB5-4649-A807-5CF51261CD39Q42370041-1BFE52FA-A86F-4CA6-8DF4-1CA48B818A44Q42702285-C28DAAF7-03A0-4921-A8B4-C5CE551E7DD0Q42866754-4F345294-B5C4-42BE-86D4-74958375B978Q42875076-36E40380-6602-4BC1-988F-B38263E6D4C2Q42920564-872C652A-28F4-42B7-82D2-30516BB6C187Q43105021-BD096919-0CB8-4443-A1AC-CFE5DF92CC55Q43767916-EF59F7B2-5AF4-42DA-9D68-D40BCE65172DQ44288888-62458E2E-BAC0-43D4-80C3-3FD550E38A86Q44343949-256850FE-2F23-41A4-A25C-E3016BAB6E15Q45037842-EFFDC246-874C-4644-B1E2-FC85A085A3D7Q46471725-DA197E45-6586-401C-A054-AE4A647E730AQ46965808-96CC45E0-F086-4CD4-8ACA-F05BA207F389Q48858031-F779A51D-9C14-4652-8114-FFD8571F93CC
P2860
Fundamental difference between the molecular interactions of agonists and antagonists with the beta-adrenergic receptor.
description
1979 nî lūn-bûn
@nan
1979年の論文
@ja
1979年学术文章
@wuu
1979年学术文章
@zh-cn
1979年学术文章
@zh-hans
1979年学术文章
@zh-my
1979年学术文章
@zh-sg
1979年學術文章
@yue
1979年學術文章
@zh
1979年學術文章
@zh-hant
name
Fundamental difference between ...... the beta-adrenergic receptor.
@en
Fundamental difference between ...... the beta-adrenergic receptor.
@nl
type
label
Fundamental difference between ...... the beta-adrenergic receptor.
@en
Fundamental difference between ...... the beta-adrenergic receptor.
@nl
prefLabel
Fundamental difference between ...... the beta-adrenergic receptor.
@en
Fundamental difference between ...... the beta-adrenergic receptor.
@nl
P2093
P2860
P356
P1433
P1476
Fundamental difference between ...... the beta-adrenergic receptor.
@en
P2093
Minneman KP
Molinoff PB
Weiland GA
P2860
P2888
P304
P356
10.1038/281114A0
P407
P577
1979-09-01T00:00:00Z
P6179
1052633940