The V-ATPase-inhibitor archazolid abrogates tumor metastasis via inhibition of endocytic activation of the Rho-GTPase Rac1.
about
TM9SF4 is a novel V-ATPase-interacting protein that modulates tumor pH alterations associated with drug resistance and invasiveness of colon cancer cellsThe expression of V-ATPase is associated with drug resistance and pathology of non-small-cell lung cancer.Activity of plasma membrane V-ATPases is critical for the invasion of MDA-MB231 breast cancer cells.CERS2 suppresses tumor cell invasion and is associated with decreased V-ATPase and MMP-2/MMP-9 activities in breast cancer.Silencing of TMSG1 enhances metastasis capacity by targeting V-ATPase in breast cancerSynthesis of the C1-C17 fragment of the archazolids by complex cis-homodimer cross metathesis.AGPAT9 suppresses cell growth, invasion and metastasis by counteracting acidic tumor microenvironment through KLF4/LASS2/V-ATPase signaling pathway in breast cancerThe vacuolar H+ ATPase is a novel therapeutic target for glioblastoma.The Vacuolar ATPase a2-subunit regulates Notch signaling in triple-negative breast cancer cellsBreast cancer associated a2 isoform vacuolar ATPase immunomodulates neutrophils: potential role in tumor progressionEndosomal Na+/H+ exchanger NHE5 influences MET recycling and cell migration.Regulation of luminal acidification by the V-ATPase.The Function of V-ATPases in CancerThe function of vacuolar ATPase (V-ATPase) a subunit isoforms in invasiveness of MCF10a and MCF10CA1a human breast cancer cells.Salinomycin treatment reduces metastatic tumor burden by hampering cancer cell migrationThe a3 isoform of subunit a of the vacuolar ATPase localizes to the plasma membrane of invasive breast tumor cells and is overexpressed in human breast cancer.Lactoferrin selectively triggers apoptosis in highly metastatic breast cancer cells through inhibition of plasmalemmal V-H+-ATPase.V-ATPase inhibition increases cancer cell stiffness and blocks membrane related Ras signaling - a new option for HCC therapy.Recent Insights into the Structure, Regulation, and Function of the V-ATPasesTotal syntheses of the archazolids: an emerging class of novel anticancer drugs.Anti-leukemic effects of the V-ATPase inhibitor Archazolid A.Polarization of the vacuolar adenosine triphosphatase delineates a transition to high-grade pancreatic intraepithelial neoplasm lesions.Resistance mechanisms of cancer cells to the novel vacuolar H(+)-ATPase inhibitor archazolid B.Natural products from myxobacteria: novel metabolites and bioactivities.V-ATPase inhibition by archazolid leads to lysosomal dysfunction resulting in impaired cathepsin B activation in vivo.V-ATPase inhibition overcomes trastuzumab resistance in breast cancer.MDM2 antagonist nutlin-3a sensitizes tumors to V-ATPase inhibition.Molecular machineries of pH dysregulation in tumor microenvironment: potential targets for cancer therapyEPR Studies of V-ATPase with Spin-Labeled Inhibitors DCC and Archazolid: Interaction Dynamics with Proton Translocating Subunit c.Acidic extracellular microenvironment and cancer.IMP2/IGF2BP2 expression, but not IMP1 and IMP3, predicts poor outcome in patients and high tumor growth rate in xenograft models of gallbladder cancer.Cleistanthin A inhibits the invasion and metastasis of human melanoma cells by inhibiting the expression of matrix metallopeptidase-2 and -9.Endolysosomal Cation Channels and Cancer-A Link with Great Potential.Repositioning of proton pump inhibitors in cancer therapy.Revealing the macromolecular targets of complex natural products.Rethinking the Combination of Proton Exchanger Inhibitors in Cancer Therapy.The curious case of vacuolar ATPase: regulation of signaling pathways.Regulation of endothelial signaling and migration by v-ATPase.V-ATPase-dependent repression of androgen receptor in prostate cancer cells.Regulation of V-ATPase Assembly in Nutrient Sensing and Function of V-ATPases in Breast Cancer Metastasis
P2860
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P2860
The V-ATPase-inhibitor archazolid abrogates tumor metastasis via inhibition of endocytic activation of the Rho-GTPase Rac1.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
The V-ATPase-inhibitor archazo ...... vation of the Rho-GTPase Rac1.
@en
The V-ATPase-inhibitor archazo ...... vation of the Rho-GTPase Rac1.
@nl
type
label
The V-ATPase-inhibitor archazo ...... vation of the Rho-GTPase Rac1.
@en
The V-ATPase-inhibitor archazo ...... vation of the Rho-GTPase Rac1.
@nl
prefLabel
The V-ATPase-inhibitor archazo ...... vation of the Rho-GTPase Rac1.
@en
The V-ATPase-inhibitor archazo ...... vation of the Rho-GTPase Rac1.
@nl
P2093
P50
P1433
P1476
The V-ATPase-inhibitor archazo ...... vation of the Rho-GTPase Rac1.
@en
P2093
Andrea Palamidessi
Angelika M Vollmar
Christina Schempp
Dirk Trauner
Gyorgy Vereb
Johanna Liebl
Karin von Schwarzenberg
Laura Schreiner
Rebekka Kubisch
Romina M Wiedmann
P304
P356
10.1158/0008-5472.CAN-12-1772
P407
P577
2012-09-17T00:00:00Z