Global analysis of genome, transcriptome and proteome reveals the response to aneuploidy in human cells. - Wikidata - awgldk - TriplyDB

Global analysis of genome, transcriptome and proteome reveals the response to aneuploidy in human cells.

Global analysis of genome, transcriptome and proteome reveals the response to aneuploidy in human cells.

http://www.wikidata.org/entity/Q39280952

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Proteomics-Based Analysis of Protein Complexes in Pluripotent Stem Cells and Cancer Biology Aneuploidy-induced cellular stresses limit autophagic degradation.Unique features of the transcriptional response to model aneuploidy in human cells Network biology concepts in complex disease comorbidities Aneuploidy Causes Non-genetic Individuality The burden of trisomy 21 disrupts the proteostasis network in Down syndrome.Quantitative proteomic analysis reveals posttranslational responses to aneuploidy in yeast.Chromosomal instability selects gene copy-number variants encoding core regulators of proliferation in ER+ breast cancer.Protein profiles in Tc1 mice implicate novel pathway perturbations in the Down syndrome brain The Hsp90-dependent proteome is conserved and enriched for hub proteins with high levels of protein-protein connectivity.Widespread Proteome Remodeling and Aggregation in Aging C. elegans.Mechanisms of x chromosome dosage compensation.Mitotic entry in the presence of DNA damage is a widespread property of aneuploidy in yeast.Aneuploidy and chromosomal instability in cancer: a jackpot to chaos.Chromosome mis-segregation and cytokinesis failure in trisomic human cells Divergence patterns of genic copy number variation in natural populations of the house mouse (Mus musculus domesticus) reveal three conserved genes with major population-specific expansions Models of buffering of dosage imbalances in protein complexes.Genome-wide gene expression perturbation induced by loss of C2 chromosome in allotetraploid Brassica napus L.Post-Translational Dosage Compensation Buffers Genetic Perturbations to Stoichiometry of Protein Complexes.Linking abnormal mitosis to the acquisition of DNA damage Aneuploidy causes proteotoxic stress in yeast Human phosphatase CDC14A is recruited to the cell leading edge to regulate cell migration and adhesion.The presence of extra chromosomes leads to genomic instability.Absence of Prenatal Forebrain Defects in the Dp(16)1Yey/+ Mouse Model of Down Syndrome.Selective advantage of trisomic human cells cultured in non-standard conditions No current evidence for widespread dosage compensation in S. cerevisiae.Chromosome-Specific and Global Effects of Aneuploidy in Saccharomyces cerevisiae Aneuploidy impairs hematopoietic stem cell fitness and is selected against in regenerating tissues in vivo Studies of mucus in mouse stomach, small intestine, and colon. II. Gastrointestinal mucus proteome reveals Muc2 and Muc5ac accompanied by a set of core proteins DNA sequencing methods in human genetics and disease research.Genome-Wide Gene/Genome Dosage Imbalance Regulates Gene Expressions in Synthetic Brassica napus and Derivatives (AC, AAC, CCA, CCAA).Aneuploidy and chromosomal instability: a vicious cycle driving cellular evolution and cancer genome chaos.Multi-layered cancer chromosomal instability phenotype.The pleiotropic deubiquitinase Ubp3 confers aneuploidy tolerance.A transcriptional and metabolic signature of primary aneuploidy is present in chromosomally unstable cancer cells and informs clinical prognosis Autophagy regulates the survival of cells with chromosomal instability.The Consequences of Chromosome Segregation Errors in Mitosis and Meiosis.Gene copy-number alterations: a cost-benefit analysis.Chromosomal instability and transcriptome dynamics in cancer.Aneuploidy: implications for protein homeostasis and disease

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Global analysis of genome, transcriptome and proteome reveals the response to aneuploidy in human cells.

http://www.wikidata.org/entity/Q39280952

description

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name

Global analysis of genome, tra ...... to aneuploidy in human cells.

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Global analysis of genome, tra ...... to aneuploidy in human cells.

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type

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Global analysis of genome, tra ...... to aneuploidy in human cells.

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Global analysis of genome, tra ...... to aneuploidy in human cells.

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Global analysis of genome, tra ...... to aneuploidy in human cells.

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Global analysis of genome, tra ...... to aneuploidy in human cells.

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Molecular Systems Biology

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Global analysis of genome, tra ...... e to aneuploidy in human cells

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Gabriele Stoehr

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Jürgen Cox

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Karolina Peplowska

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Matthias Mann

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Silvia Stingele

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P2860

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

Aneuploidy affects proliferation and spontaneous immortalization in mammalian cells

Dosage balance in gene regulation: biological implications

Gene Expression Omnibus: NCBI gene expression and hybridization array data repository

Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics

From polyploidy to aneuploidy, genome instability and cancer

Identification of aneuploidy-tolerating mutations

Genetic Instability Caused by Loss of MutS Homologue 3 in Human Colorectal Cancer

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10.1038/MSB.2012.40

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Zuzana Storchova

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230832923

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