Genetic and epigenetic loss of microRNA-31 leads to feed-forward expression of EZH2 in melanoma. - Wikidata - awgldk - TriplyDB

Genetic and epigenetic loss of microRNA-31 leads to feed-forward expression of EZH2 in melanoma.

Genetic and epigenetic loss of microRNA-31 leads to feed-forward expression of EZH2 in melanoma.

http://www.wikidata.org/entity/Q39285644

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Intravital imaging of SRF and Notch signalling identifies a key role for EZH2 in invasive melanoma cells Targeting activating mutations of EZH2 leads to potent cell growth inhibition in human melanoma by derepression of tumor suppressor genes EZH2 as a mediator of treatment resistance in melanoma Epigenetic regulation in human melanoma: past and future Epigenetic reduction of DNA repair in progression to gastrointestinal cancer JNK and STAT3 signaling pathways converge on Akt-mediated phosphorylation of EZH2 in bronchial epithelial cells induced by arsenic Expression of circulating miRNAs associated with lymphocyte differentiation and activation in CLL-another piece in the puzzle.EZH2: not EZHY (easy) to deal.miR-31 is consistently inactivated in EBV-associated nasopharyngeal carcinoma and contributes to its tumorigenesis MicroRNA-31 suppresses medulloblastoma cell growth by inhibiting DNA replication through minichromosome maintenance 2 Role of microRNAs and DNA Methyltransferases in Transmitting Induced Genomic Instability between Cell Generations.The role of microRNAs and long non-coding RNAs in the pathology, diagnosis, and management of melanoma Polycomb protein EZH2 suppresses apoptosis by silencing the proapoptotic miR-31.Pharmacologic down-regulation of EZH2 suppresses bladder cancer in vitro and in vivo.NF-κB inducing kinase, a central signaling component of the non-canonical pathway of NF-κB, contributes to ovarian cancer progression.Low miR-34a and miR-192 are associated with unfavorable prognosis in patients suffering from osteosarcoma.SOX4 interacts with EZH2 and HDAC3 to suppress microRNA-31 in invasive esophageal cancer cells MicroRNA-31 controls G protein alpha-13 (GNA13) expression and cell invasion in breast cancer cells MicroRNA-31 is a transcriptional target of histone deacetylase inhibitors and a regulator of cellular senescence MiR-144 Inhibits Uveal Melanoma Cell Proliferation and Invasion by Regulating c-Met Expression.MicroRNA-31 functions as a tumor suppressor by regulating cell cycle and epithelial-mesenchymal transition regulatory proteins in liver cancer.microRNA-217 inhibits tumor progression and metastasis by downregulating EZH2 and predicts favorable prognosis in gastric cancer.An integrative pan-cancer-wide analysis of epigenetic enzymes reveals universal patterns of epigenomic deregulation in cancer MicroRNA-1297 regulates hepatocellular carcinoma cell proliferation and apoptosis by targeting EZH2.Kaiso, a transcriptional repressor, promotes cell migration and invasion of prostate cancer cells through regulation of miR-31 expression.The relationship between EZH2 expression and microRNA-31 in colorectal cancer and the role in evolution of the serrated pathway EZH2 and ALDH1 expression in ductal carcinoma in situ: complex association with recurrence and progression to invasive breast cancer.Ultraviolet radiation-induced tumor necrosis factor alpha, which is linked to the development of cutaneous SCC, modulates differential epidermal microRNAs expression.Natural compound-derived epigenetic regulators targeting epigenetic readers, writers and erasers.Activation of miR200 by c-Myb depends on ZEB1 expression and miR200 promoter methylation Role of EZH2 histone methyltrasferase in melanoma progression and metastasis Targeting EZH2 for cancer therapy: progress and perspective.Deregulation of let-7e in epithelial ovarian cancer promotes the development of resistance to cisplatin.Regulation of microRNAs by epigenetics and their interplay involved in cancer.The polycomb group protein EZH2 is a novel therapeutic target in tongue cancer.Aberrant DNA methylation in melanoma: biomarker and therapeutic opportunities.The diverse role of miR-31 in regulating cancer associated phenotypes.Epigenetics of melanoma: implications for immune-based therapies.EZH2: an emerging role in melanoma biology and strategies for targeted therapy.Melanoma epigenetics: novel mechanisms, markers, and medicines.

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P2860

Genetic and epigenetic loss of microRNA-31 leads to feed-forward expression of EZH2 in melanoma.

http://www.wikidata.org/entity/Q39285644

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Genetic and epigenetic loss of ...... xpression of EZH2 in melanoma.

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Genetic and epigenetic loss of ...... xpression of EZH2 in melanoma.

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Genetic and epigenetic loss of ...... xpression of EZH2 in melanoma.

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Genetic and epigenetic loss of ...... xpression of EZH2 in melanoma.

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Christopher A Maher

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Douglas R Fullen

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Lakshmi P Kunju

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Lois Dodson

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P2860

A landscape of driver mutations in melanoma

Pro-tumorigenic effects of miR-31 loss in mesothelioma.

miR-21 and miR-31 converge on TIAM1 to regulate migration and invasion of colon carcinoma cells

A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasis

EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells

Melanoma: new insights and new therapies

Mutations of the BRAF gene in human cancer

Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths

Diagnostic and prognostic implications of microRNA profiling in prostate carcinoma

MiR-21 overexpression in human primary squamous cell lung carcinoma is associated with poor patient prognosis

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9

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3

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Nallasivam Palanisamy

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22948084

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