Gemcitabine triggers a pro-survival response in pancreatic cancer cells through activation of the MNK2/eIF4E pathway.
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Splicing Regulation: A Molecular Device to Enhance Cancer Cell AdaptationPosttranscriptional Regulation of Splicing Factor SRSF1 and Its Role in Cancer Cell BiologySplicing Regulators and Their Roles in Cancer Biology and TherapyMnk kinase pathway: Cellular functions and biological outcomesRegulation of the Ras-MAPK and PI3K-mTOR Signalling Pathways by Alternative Splicing in CancerPhosphorylation-mediated regulation of alternative splicing in cancerDefective control of pre-messenger RNA splicing in human diseaseThe role of splicing factors in deregulation of alternative splicing during oncogenesis and tumor progressionNuclear receptors and pathogenesis of pancreatic cancer.MNKs act as a regulatory switch for eIF4E1 and eIF4E3 driven mRNA translation in DLBCL.Expression of miR-296-5p as predictive marker for radiotherapy resistance in early-stage laryngeal carcinoma.Quantitative Proteomic Analysis of Differentially Expressed Protein Profiles Involved in Pancreatic Ductal AdenocarcinomaInhibition of Mitogen-activated Protein Kinase (MAPK)-interacting Kinase (MNK) Preferentially Affects Translation of mRNAs Containing Both a 5'-Terminal Cap and Hairpin.mRNA splicing variants: exploiting modularity to outwit cancer therapyPhosphorylation of eIF4E promotes EMT and metastasis via translational control of SNAIL and MMP-3.The prognostic potential of alternative transcript isoforms across human tumors.Selective disruption of rb-raf-1 kinase interaction inhibits pancreatic adenocarcinoma growth irrespective of gemcitabine sensitivity.MNK1 pathway activity maintains protein synthesis in rapalog-treated gliomas.Distinct splice variants and pathway enrichment in the cell-line models of aggressive human breast cancer subtypesThe centrosomal kinase NEK2 is a novel splicing factor kinase involved in cell survival.Alternative splicing programs in prostate cancer.Eukaryotic translation initiation factor 4E as a novel therapeutic target in hematological malignancies and beyond.Modulation of PKM alternative splicing by PTBP1 promotes gemcitabine resistance in pancreatic cancer cells.Differential Regulation of ZEB1 and EMT by MAPK-Interacting Protein Kinases (MNK) and eIF4E in Pancreatic Cancer.Targeting translation: eIF4E as an emerging anticancer drug target.The CRISPR/Cas system inhibited the pro-oncogenic effects of alternatively spliced fibronectin extra domain A via editing the genome in salivary adenoid cystic carcinoma cells.Alternative splicing and cell survival: from tissue homeostasis to disease.MNK Controls mTORC1:Substrate Association through Regulation of TELO2 Binding with mTORC1.Combined therapy with RAD001 e BEZ235 overcomes resistance of PET immortalized cell lines to mTOR inhibition.COUP-TFII in pancreatic adenocarcinoma: clinical implication for patient survival and tumor progression.The role of RNA alternative splicing in regulating cancer metabolism.Galeterone and its analogs inhibit Mnk-eIF4E axis, synergize with gemcitabine, impede pancreatic cancer cell migration, invasion and proliferation and inhibit tumor growth in miceMAP kinase-interacting serine/threonine kinase 2 promotes proliferation, metastasis, and predicts poor prognosis in non-small cell lung cancer.Alternative polyadenylation of ZEB1 promotes its translation during genotoxic stress in pancreatic cancer cells.Exploiting differential RNA splicing patterns: a potential new group of therapeutic targets in cancer.Pancreatic tumours escape from translational control through 4E-BP1 loss.eIF4E Phosphorylation in Prostate Cancer.Increased expression of MNK1b, the spliced isoform of MNK1, predicts poor prognosis and is associated with triple-negative breast cancer.
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Gemcitabine triggers a pro-survival response in pancreatic cancer cells through activation of the MNK2/eIF4E pathway.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
Gemcitabine triggers a pro-sur ...... ion of the MNK2/eIF4E pathway.
@en
Gemcitabine triggers a pro-sur ...... ion of the MNK2/eIF4E pathway.
@nl
type
label
Gemcitabine triggers a pro-sur ...... ion of the MNK2/eIF4E pathway.
@en
Gemcitabine triggers a pro-sur ...... ion of the MNK2/eIF4E pathway.
@nl
prefLabel
Gemcitabine triggers a pro-sur ...... ion of the MNK2/eIF4E pathway.
@en
Gemcitabine triggers a pro-sur ...... ion of the MNK2/eIF4E pathway.
@nl
P2093
P2860
P50
P356
P1433
P1476
Gemcitabine triggers a pro-sur ...... tion of the MNK2/eIF4E pathway
@en
P2093
G Delle Fave
S Calabretta
P2860
P2888
P304
P356
10.1038/ONC.2012.306
P407
P577
2012-07-16T00:00:00Z