Protein arginine methyltransferase 5 is a potential oncoprotein that upregulates G1 cyclins/cyclin-dependent kinases and the phosphoinositide 3-kinase/AKT signaling cascade.
about
A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL modelsHistone methylation modifiers in cellular signaling pathwaysThe PRMT5 arginine methyltransferase: many roles in development, cancer and beyondDistinct lymphocyte antigens 6 (Ly6) family members Ly6D, Ly6E, Ly6K and Ly6H drive tumorigenesis and clinical outcomePrediction of cancer proteins by integrating protein interaction, domain frequency, and domain interaction data using machine learning algorithms.Sox9 mediates Notch1-induced mesenchymal features in lung adenocarcinoma.Drug repositioning discovery for early- and late-stage non-small-cell lung cancer.An Arf-Egr-C/EBPβ pathway linked to ras-induced senescence and cancer.PRMT5 is upregulated in malignant and metastatic melanoma and regulates expression of MITF and p27(Kip1.).Evolutionary emergence of a novel splice variant with an opposite effect on the cell cycle.Musashi-2 Silencing Exerts Potent Activity against Acute Myeloid Leukemia and Enhances Chemosensitivity to DaunorubicinMethylosome Protein 50 and PKCδ/p38δ Protein Signaling Control Keratinocyte Proliferation via Opposing Effects on p21Cip1 Gene ExpressionDrug repositioning for non-small cell lung cancer by using machine learning algorithms and topological graph theory.High expression of long non-coding RNA SBF2-AS1 promotes proliferation in non-small cell lung cancer.Comprehensive analysis of lncRNA expression profiles and identification of functional lncRNAs in lung adenocarcinoma.PRMT5 dimethylates R30 of the p65 subunit to activate NF-κB.Methods to increase reproducibility in differential gene expression via meta-analysis.PRMT5 competitively binds to CDK4 to promote G1-S transition upon glucose induction in hepatocellular carcinoma.Role of protein arginine methyltransferase 5 in inflammation and migration of fibroblast-like synoviocytes in rheumatoid arthritis.Nuclear PRMT5, cyclin D1 and IL-6 are associated with poor outcome in oropharyngeal squamous cell carcinoma patients and is inversely associated with p16-status.Protein arginine methylation of non-histone proteins and its role in diseases.Plakophilins in desmosomal adhesion and signaling.Structure and Property Guided Design in the Identification of PRMT5 Tool Compound EPZ015666.Elevated expression of protein arginine methyltransferase 5 predicts the poor prognosis of breast cancer.Inhibitors of Protein Methyltransferases and Demethylases.Protein arginine methylation/demethylation and cancer.Transcriptional activation of PRMT5 by NF-Y is required for cell growth and negatively regulated by the PKC/c-Fos signaling in prostate cancer cells.Development of Kras mutant lung adenocarcinoma in mice with knockout of the airway lineage-specific gene Gprc5a.Integrative analysis for the discovery of lung cancer serological markers and validation by MRM-MS.Upregulation of CISD2 augments ROS homeostasis and contributes to tumorigenesis and poor prognosis of lung adenocarcinoma.Protein arginine methyltransferase 5 functions as an epigenetic activator of the androgen receptor to promote prostate cancer cell growth.Individual-level analysis of differential expression of genes and pathways for personalized medicine.TBX2 subfamily suppression in lung cancer pathogenesis: a high-potential marker for early detection.Diagnostic significance of circulating long noncoding RNA PCAT6 in patients with non-small cell lung cancer.Sulforaphane suppresses PRMT5/MEP50 function in epidermal squamous cell carcinoma leading to reduced tumor formation.PRMT5 promotes cell proliferation by inhibiting BTG2 expression via the ERK signaling pathway in hepatocellular carcinoma.Unique Immune Gene Expression Patterns in Bronchoalveolar Lavage and Tumor Adjacent Non-Neoplastic Lung Tissue in Non-Small Cell Lung Cancer.Identification of a Novel Protein Arginine Methyltransferase 5 Inhibitor in Non-small Cell Lung Cancer by Structure-Based Virtual Screening.Cryo-electron microscopy structure of a human PRMT5:MEP50 complex.Protein arginine methylation: an emerging regulator of the cell cycle.
P2860
Q27700259-30A05E88-1757-4F7E-87D9-2C91C70E08FDQ28082123-F5A99FCE-E8DF-410F-8AE3-D9916DFDEFEAQ28085672-AC01CA0D-0E5E-4A33-80D7-2195A962BC8BQ28273187-AC5CBCC4-342C-48C2-BC3A-0F21A2A31353Q30930272-053D8A2F-3160-49C9-9DBE-53380B4DD667Q33976991-12C516B4-15C6-4A15-B689-8FA2E9719685Q34145973-058386F7-E9B4-498E-8B63-8D239340CC1FQ34455378-59C31509-02BA-4F91-A329-5B03C89DEFDCQ35009896-CA0F09DD-E3A5-4769-A992-F5B2DA6066DCQ35626092-2966D0F8-EA5B-4C7D-8BE9-894FE00EDA34Q35755864-1F805E67-2554-474C-A170-6949AEF1BD5BQ35861025-4F14DAB9-CE12-47AF-A579-C7D46BBEF95CQ35906092-72ECE106-BDAF-4B2F-A932-8078800AC28AQ36879769-310014B6-B6FA-4A69-B2C8-5CA07D20E863Q37085938-70A71664-2FA2-4266-97E3-B42437709FF9Q37103890-9331D26C-CCEC-4D1A-9D66-22A79B6576D1Q37577407-4ED5E751-8078-40B8-A852-6A99D90F4C72Q37687790-A2BBB261-D894-4379-A661-6BC2F2860068Q37693442-E41EC16A-3A06-40D2-875E-C900A01D64FDQ37716457-A60EE845-A89C-4E08-BD3E-3B7A82E70870Q38168045-73AD460C-9C78-4BA7-9685-BB354826FE8AQ38181535-F579E6BA-72AB-4FD2-8726-12243EDABF9DQ38434145-8BAAA9C1-E149-47A8-9B04-44480D4CD0BDQ38708747-CAD1E4A4-A18F-4013-A60A-643E0DFA6A59Q38740496-ED52C205-BF22-4206-A13F-C6B16C094ABEQ38935888-81B2109C-9702-4DE9-A0B9-EEA38615F323Q38950645-B70075B7-9AF0-4C22-874D-07AFED2A016DQ40144219-2D6EF0A0-CBAB-47E2-9ED6-64079D73BB6AQ41513462-80D05BA8-36DE-4BF4-A78F-463A86AA2F59Q41717532-F9BF6CF1-56D6-4B7D-9E0F-20AD81C1C0D0Q42036127-D1A227C1-C109-410B-9A54-67329FEB5AEEQ42200053-0CC9B130-892F-4AFA-8128-BB263471A05FQ42366611-04B7B2F1-F412-4EE5-AD5E-194F293FDCDEQ47105611-5026D13F-6AB9-474E-B8BB-E842CBCA416EQ47882971-862854AB-01E6-49DA-A452-922C27EB69B6Q50019708-68BB8495-6BB1-48E3-BB1D-CDF08648BD43Q50300234-025CAEE1-E25B-4461-AE8E-7AB271AA78F0Q52353697-FCB3B7A9-227B-4D8B-AA9D-80EC52EF8487Q52362886-86AF85C9-7B33-4A98-B732-A6A18DB33856Q52724818-8D1A35DF-60EC-4D86-863D-4FBB00A2FA34
P2860
Protein arginine methyltransferase 5 is a potential oncoprotein that upregulates G1 cyclins/cyclin-dependent kinases and the phosphoinositide 3-kinase/AKT signaling cascade.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
Protein arginine methyltransfe ...... -kinase/AKT signaling cascade.
@en
Protein arginine methyltransfe ...... -kinase/AKT signaling cascade.
@nl
type
label
Protein arginine methyltransfe ...... -kinase/AKT signaling cascade.
@en
Protein arginine methyltransfe ...... -kinase/AKT signaling cascade.
@nl
prefLabel
Protein arginine methyltransfe ...... -kinase/AKT signaling cascade.
@en
Protein arginine methyltransfe ...... -kinase/AKT signaling cascade.
@nl
P2093
P2860
P1433
P1476
Protein arginine methyltransfe ...... -kinase/AKT signaling cascade.
@en
P2093
Chang-Tze R Yu
Chi-Chang Juan
Chung-Ping Hsu
Hsiang-Yun Chou
Jiun-Yi Hisa
Jo-Mei M Chen
Kuo-Lin Liu
Shao-Chih Chiu
Tong-You W Wei
P2860
P304
P356
10.1111/J.1349-7006.2012.02367.X
P577
2012-08-08T00:00:00Z