The anti-Fn14 antibody BIIB036 inhibits tumor growth in xenografts and patient derived primary tumor models and enhances efficacy of chemotherapeutic agents in multiple xenograft models.
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Inflammatory cytokines and survival factors from serum modulate tweak-induced apoptosis in PC-3 prostate cancer cells.Predictive gene signature of response to the anti-TweakR mAb PDL192 in patient-derived breast cancer xenograftsTWEAK-independent Fn14 self-association and NF-κB activation is mediated by the C-terminal region of the Fn14 cytoplasmic domainDevelopment of human serine protease-based therapeutics targeting Fn14 and identification of Fn14 as a new target overexpressed in TNBC.Clinical targeting of the TNF and TNFR superfamiliesAntitumor activity of a humanized, bivalent immunotoxin targeting fn14-positive solid tumorsTWEAK activation of the non-canonical NF-κB signaling pathway differentially regulates melanoma and prostate cancer cell invasion.TWEAK/Fn14 signaling in tumors.Low blood levels of sTWEAK are related to locoregional failure in head and neck cancer.TWEAK/Fn14 Axis-Targeted Therapeutics: Moving Basic Science Discoveries to the Clinic.
P2860
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P2860
The anti-Fn14 antibody BIIB036 inhibits tumor growth in xenografts and patient derived primary tumor models and enhances efficacy of chemotherapeutic agents in multiple xenograft models.
description
2012 nî lūn-bûn
@nan
2012年の論文
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2012年学术文章
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2012年学术文章
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2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
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2012年學術文章
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2012年學術文章
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name
The anti-Fn14 antibody BIIB036 ...... in multiple xenograft models.
@en
The anti-Fn14 antibody BIIB036 ...... in multiple xenograft models.
@nl
type
label
The anti-Fn14 antibody BIIB036 ...... in multiple xenograft models.
@en
The anti-Fn14 antibody BIIB036 ...... in multiple xenograft models.
@nl
prefLabel
The anti-Fn14 antibody BIIB036 ...... in multiple xenograft models.
@en
The anti-Fn14 antibody BIIB036 ...... in multiple xenograft models.
@nl
P2093
P2860
P921
P356
P1476
The anti-Fn14 antibody BIIB036 ...... in multiple xenograft models.
@en
P2093
Ingrid B J K Joseph
Jennifer S Michaelson
Kathleen Wortham
Rebecca Kelly
Xiamei Zhang
P2860
P304
P356
10.4161/CBT.20564
P577
2012-06-06T00:00:00Z