FimH antagonists: structure-activity and structure-property relationships for biphenyl α-D-mannopyranosides.
about
The tyrosine gate of the bacterial lectin FimH: a conformational analysis by NMR spectroscopy and X-ray crystallographyMutation of Tyr137 of the universal Escherichia coli fimbrial adhesin FimH relaxes the tyrosine gate prior to mannose binding.Antivirulence Isoquinolone Mannosides: Optimization of the Biaryl Aglycone for FimH Lectin Binding Affinity and Efficacy in the Treatment of Chronic UTI.Target-directed Dynamic Combinatorial Chemistry: A Study on Potentials and Pitfalls as Exemplified on a Bacterial Target.Rational design strategies for FimH antagonists: new drugs on the horizon for urinary tract infection and Crohn's disease.Sites for Dynamic Protein-Carbohydrate Interactions of O- and C-Linked Mannosides on the E. coli FimH Adhesin.Antivirulence C-Mannosides as Antibiotic-Sparing, Oral Therapeutics for Urinary Tract InfectionsThe Conformational Variability of FimH: Which Conformation Represents the Therapeutic Target?Conformational Switch of the Bacterial Adhesin FimH in the Absence of the Regulatory Domain - Engineering a Minimalistic Allosteric System.The price of flexibility - a case study on septanoses as pyranose mimetics.Kinetic properties of carbohydrate-lectin interactions: FimH antagonists.
P2860
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P2860
FimH antagonists: structure-activity and structure-property relationships for biphenyl α-D-mannopyranosides.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
FimH antagonists: structure-ac ...... biphenyl α-D-mannopyranosides.
@en
FimH antagonists: structure-ac ...... biphenyl α-D-mannopyranosides.
@nl
type
label
FimH antagonists: structure-ac ...... biphenyl α-D-mannopyranosides.
@en
FimH antagonists: structure-ac ...... biphenyl α-D-mannopyranosides.
@nl
prefLabel
FimH antagonists: structure-ac ...... biphenyl α-D-mannopyranosides.
@en
FimH antagonists: structure-ac ...... biphenyl α-D-mannopyranosides.
@nl
P2093
P2860
P356
P1433
P1476
FimH antagonists: structure-ac ...... biphenyl α-D-mannopyranosides.
@en
P2093
Adam Zalewski
Beat Ernst
Florentina Schädler
Katrin Lemme
Lijuan Pang
Meike Scharenberg
Oliver Schwardt
Said Rabbani
Simon Kleeb
P2860
P304
P356
10.1002/CMDC.201200125
P577
2012-05-29T00:00:00Z