Two modes of polyamine block regulating the cardiac inward rectifier K+ current IK1 as revealed by a study of the Kir2.1 channel expressed in a human cell line.
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The anti-protozoal drug pentamidine blocks KIR2.x-mediated inward rectifier current by entering the cytoplasmic pore region of the channel.Experimental Mapping of the Canine KCNJ2 and KCNJ12 Gene Structures and Functional Analysis of the Canine K(IR)2.2 ion ChannelRevisiting inward rectification: K ions permeate through Kir2.1 channels during high-affinity block by spermidine.Spermine, a molecular switch regulating EGFR, integrin β3, Src, and FAK scaffolding.Functional roles of charged amino acid residues on the wall of the cytoplasmic pore of Kir2.1.Interactions of external K+ and internal blockers in a weak inward-rectifier K+ channel.A synergistic blocking effect of Mg²⁺ and spermine on the inward rectifier K⁺ (Kir2.1) channel pore.Heterogeneity of IK1 in the mouse heart.Low-affinity spermine block mediating outward currents through Kir2.1 and Kir2.2 inward rectifier potassium channels.Two Kir2.1 channel populations with different sensitivities to Mg(2+) and polyamine block: a model for the cardiac strong inward rectifier K(+) channel.Inter-individual variability and modeling of electrical activity: a possible new approach to explore cardiac safety?The bundle crossing region is responsible for the inwardly rectifying internal spermine block of the Kir2.1 channel.Mechanism of inward rectification in Kir channels.Different intracellular polyamine concentrations underlie the difference in the inward rectifier K(+) currents in atria and ventricles of the guinea-pig heart.Differential polyamine sensitivity in inwardly rectifying Kir2 potassium channels.
P2860
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P2860
Two modes of polyamine block regulating the cardiac inward rectifier K+ current IK1 as revealed by a study of the Kir2.1 channel expressed in a human cell line.
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name
Two modes of polyamine block r ...... xpressed in a human cell line.
@en
Two modes of polyamine block r ...... xpressed in a human cell line.
@nl
type
label
Two modes of polyamine block r ...... xpressed in a human cell line.
@en
Two modes of polyamine block r ...... xpressed in a human cell line.
@nl
prefLabel
Two modes of polyamine block r ...... xpressed in a human cell line.
@en
Two modes of polyamine block r ...... xpressed in a human cell line.
@nl
P2860
P1476
Two modes of polyamine block r ...... xpressed in a human cell line.
@en
P2093
Keiko Ishihara
Tsuguhisa Ehara
P2860
P356
10.1113/JPHYSIOL.2003.055434
P407
P577
2004-01-14T00:00:00Z