Complexity of immune responses to AAV transgene products - Example of factor IX.

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Innovative Approaches for Immune Tolerance to Factor VIII in the Treatment of Hemophilia A.Gene Therapy With Regulatory T Cells: A Beneficial Alliance.

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Complexity of immune responses to AAV transgene products - Example of factor IX.

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Complexity of immune responses to AAV transgene products - Example of factor IX.

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Complexity of immune responses to AAV transgene products - Example of factor IX.

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Complexity of immune responses to AAV transgene products - Example of factor IX.

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Complexity of immune responses to AAV transgene products - Example of factor IX.

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Complexity of immune responses to AAV transgene products - Example of factor IX.

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Complexity of immune responses to AAV transgene products - Example of factor IX.

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Complexity of immune responses to AAV transgene products - Example of factor IX.

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Roland W Herzog

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Role of the vector genome and underlying factor IX mutation in immune responses to AAV gene therapy for hemophilia B

Self-complementary AAVs induce more potent transgene product-specific immune responses compared to a single-stranded genome

Clinical development of gene therapy: results and lessons from recent successes

Targeted approaches to induce immune tolerance for Pompe disease therapy

Mechanism of oral tolerance induction to therapeutic proteins

Gene therapy for hemophilia

Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response

Translational data from adeno-associated virus-mediated gene therapy of hemophilia B in dogs

Early clinical data raise the bar for hemophilia gene therapies.

Hepatic gene transfer as a means of tolerance induction to transgene products

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scholarly article

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10.1016/J.CELLIMM.2017.05.006

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2017-05-29T00:00:00Z

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28645365

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5708148

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Complexity of immune responses to AAV transgene products - Example of factor IX.

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P2860

P2860

Complexity of immune responses to AAV transgene products - Example of factor IX.

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P1476

P2093

P2860

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P577

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P1476

P2093

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P356

P577

P698

P932