p85α SH2 domain phosphorylation by IKK promotes feedback inhibition of PI3K and Akt in response to cellular starvation.
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Context-Dependent Regulation of Autophagy by IKK-NF-κB Signaling: Impact on the Aging ProcessThe language of SH2 domain interactions defines phosphotyrosine-mediated signal transductionApplication of multiplexed kinase inhibitor beads to study kinome adaptations in drug-resistant leukemiaInactivation of BAD by IKK inhibits TNFα-induced apoptosis independently of NF-κB activationAkt phosphorylation and regulation of transketolase is a nodal point for amino acid control of purine synthesisAkt-dependent activation of mTORC1 complex involves phosphorylation of mTOR (mammalian target of rapamycin) by IκB kinase α (IKKα).A Proteome-wide Domain-centric Perspective on Protein Phosphorylation.Metabolic control of autophagyIKBKE phosphorylation and inhibition of FOXO3a: a mechanism of IKBKE oncogenic function.PKD1 mediates negative feedback of PI3K/Akt activation in response to G protein-coupled receptors.The IκB kinase complex in NF-κB regulation and beyond.Loss of IKKβ but Not NF-κB p65 Skews Differentiation towards Myeloid over Erythroid Commitment and Increases Myeloid Progenitor Self-Renewal and Functional Long-Term Hematopoietic Stem Cells.KIM-1-/TIM-1-mediated phagocytosis links ATG5-/ULK1-dependent clearance of apoptotic cells to antigen presentation.Oncogenic mutations mimic and enhance dynamic events in the natural activation of phosphoinositide 3-kinase p110α (PIK3CA).Akt Pathway Activation by Human T-cell Leukemia Virus Type 1 Tax Oncoprotein.Muscle Wasting in Fasting Requires Activation of NF-κB and Inhibition of AKT/Mechanistic Target of Rapamycin (mTOR) by the Protein Acetylase, GCN5.NF-κB Essential Modulator (NEMO) Is Critical for Thyroid Function.Macrophage IKKα Deficiency Suppresses Akt Phosphorylation, Reduces Cell Survival, and Decreases Early AtherosclerosisIKKβ promotes metabolic adaptation to glutamine deprivation via phosphorylation and inhibition of PFKFB3.BRD7, a tumor suppressor, interacts with p85α and regulates PI3K activity.AKTivation of PI3K/AKT/mTOR signaling pathway by KSHV.Tyrosine phosphorylation of the Lyn Src homology 2 (SH2) domain modulates its binding affinity and specificity.Hyperosmotic stress stimulates autophagy via polycystin-2.Domain analysis reveals striking functional differences between the regulatory subunits of phosphatidylinositol 3-kinase (PI3K), p85α and p85β.Regulation of autophagy by glucose in Mammalian cells.Context-Dependent Role of IKKβ in Cancer.Interaction between CD133 and PI3K-p85 promotes chemoresistance in gastric cancer cells.Crosstalk between the Warburg effect, redox regulation and autophagy induction in tumourigenesis.
P2860
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P2860
p85α SH2 domain phosphorylation by IKK promotes feedback inhibition of PI3K and Akt in response to cellular starvation.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
p85α SH2 domain phosphorylatio ...... sponse to cellular starvation.
@en
p85α SH2 domain phosphorylatio ...... sponse to cellular starvation.
@nl
type
label
p85α SH2 domain phosphorylatio ...... sponse to cellular starvation.
@en
p85α SH2 domain phosphorylatio ...... sponse to cellular starvation.
@nl
prefLabel
p85α SH2 domain phosphorylatio ...... sponse to cellular starvation.
@en
p85α SH2 domain phosphorylatio ...... sponse to cellular starvation.
@nl
P2093
P2860
P1433
P1476
p85α SH2 domain phosphorylatio ...... sponse to cellular starvation.
@en
P2093
Albert S Baldwin
Jessica E Hutti
Patricia Cogswell
William C Comb
P2860
P304
P356
10.1016/J.MOLCEL.2012.01.010
P577
2012-02-16T00:00:00Z