Regulation of the Mdm2-p53 signaling axis in the DNA damage response and tumorigenesis.

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A small molecule drug promoting miRNA processing induces alternative splicing of MdmX transcript and rescues p53 activity in human cancer cells overexpressing MdmX protein The Role of MDM2 in Promoting Genome Stability versus Instability.

P2860

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Regulation of the Mdm2-p53 signaling axis in the DNA damage response and tumorigenesis.

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http://www.wikidata.org/entity/Q39424924

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2016 nî lūn-bûn

@nan

2016年の論文

@ja

2016年学术文章

@wuu

2016年学术文章

@zh-cn

2016年学术文章

@zh-hans

2016年学术文章

@zh-my

2016年学术文章

@zh-sg

2016年學術文章

@yue

2016年學術文章

@zh

2016年學術文章

@zh-hant

name

Regulation of the Mdm2-p53 signaling axis in the DNA damage response and tumorigenesis.

@en

Regulation of the Mdm2-p53 signaling axis in the DNA damage response and tumorigenesis.

@nl

type

Item

label

Regulation of the Mdm2-p53 signaling axis in the DNA damage response and tumorigenesis.

@en

Regulation of the Mdm2-p53 signaling axis in the DNA damage response and tumorigenesis.

@nl

prefLabel

Regulation of the Mdm2-p53 signaling axis in the DNA damage response and tumorigenesis.

@en

Regulation of the Mdm2-p53 signaling axis in the DNA damage response and tumorigenesis.

@nl

P1476

Regulation of the Mdm2-p53 signaling axis in the DNA damage response and tumorigenesis.

@en

P2093

Michael I Carr

http://www.w3.org/2001/XMLSchema#string

Stephen N Jones

http://www.w3.org/2001/XMLSchema#string

P2860

A role for ATR in the DNA damage-induced phosphorylation of p53

The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage

p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage

Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein

Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization

Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase

The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2

Critical role for Daxx in regulating Mdm2

The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop

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707-724

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scholarly article

P356

10.21037/TCR.2016.11.75

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P433

http://www.w3.org/2001/XMLSchema#string

P478

http://www.w3.org/2001/XMLSchema#string

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2016-12-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

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28690977

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P921

DNA damage

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5501481

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Regulation of the Mdm2-p53 signaling axis in the DNA damage response and tumorigenesis.

about

P2860

P2860

Regulation of the Mdm2-p53 signaling axis in the DNA damage response and tumorigenesis.

description

name

type

label

prefLabel

P1433

P1476

P2093

P2860

P304

P31

P356

P433

P478

P577

P698

P921

P932

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P433

P478

P577

P698

P921

P932