PARP inhibition sensitizes childhood high grade glioma, medulloblastoma and ependymoma to radiation. - Wikidata - awgldk - TriplyDB

PARP inhibition sensitizes childhood high grade glioma, medulloblastoma and ependymoma to radiation.

PARP inhibition sensitizes childhood high grade glioma, medulloblastoma and ependymoma to radiation.

http://www.wikidata.org/entity/Q39425287

about

TNKS1BP1 functions in DNA double-strand break repair though facilitating DNA-PKcs autophosphorylation dependent on PARP-1 In vitro drug response and efflux transporters associated with drug resistance in pediatric high grade glioma and diffuse intrinsic pontine glioma A chemical screen for medulloblastoma identifies quercetin as a putative radiosensitizer A phase I trial of veliparib (ABT-888) and temozolomide in children with recurrent CNS tumors: a pediatric brain tumor consortium report Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascade inhibitors: how mutations can result in therapy resistance and how to overcome resistance.Critical role of zinc finger protein 521 in the control of growth, clonogenicity and tumorigenic potential of medulloblastoma cells.Kinetics of porphyrin fluorescence accumulation in pediatric brain tumor cells incubated in 5-aminolevulinic acid.XAV939-mediated ARTD activity inhibition in human MB cell lines.Characterization of medulloblastoma in Fanconi Anemia: a novel mutation in the BRCA2 gene and SHH molecular subgroup PARP targeting counteracts gliomagenesis through induction of mitotic catastrophe and aggravation of deficiency in homologous recombination in PTEN-mutant glioma BRCC3 acts as a prognostic marker in nasopharyngeal carcinoma patients treated with radiotherapy and mediates radiation resistance in vitro.Molecular profiling of childhood cancer: Biomarkers and novel therapies HER2 overexpression renders human breast cancers sensitive to PARP inhibition independently of any defect in homologous recombination DNA repair.Quantifying the CDK inhibitor VMY-1-103's activity and tissue levels in an in vivo tumor model by LC-MS/MS and by MRI.Evaluation of candidate biomarkers to predict cancer cell sensitivity or resistance to PARP-1 inhibitor treatment Tissue-specific expression of p73 C-terminal isoforms in mice.Poly (ADP) ribose polymerase inhibition: A potential treatment of malignant peripheral nerve sheath tumor.The rationale for targeted therapies in medulloblastoma.Therapeutic targeting of constitutive PARP activation compromises stem cell phenotype and survival of glioblastoma-initiating cells.Paediatric and adult malignant glioma: close relatives or distant cousins?Pediatric high grade glioma: a review and update on tumor clinical characteristics and biology.Overcoming the blood-brain barrier in chemotherapy treatment of pediatric brain tumors.Pediatric diffuse intrinsic pontine glioma: can optimism replace pessimism?PARP1 expression and its correlation with survival is tumour molecular subtype dependent in glioblastoma.MicroRNA-31 modulates tumour sensitivity to radiation in oesophageal adenocarcinoma.Targeting the fanconi anemia pathway to identify tailored anticancer therapeutics.Poly-(ADP-ribose)-polymerase inhibitors as radiosensitizers: a systematic review of pre-clinical and clinical human studies.Linking off-target kinase pharmacology to the differential cellular effects observed among PARP inhibitors.Current treatment options for pediatric and adult patients with ependymoma.MutT homolog 1 counteracts the effect of anti-neoplastic treatments in adult and pediatric glioblastoma cells.Genomic profiling reveals distinctive molecular relapse patterns in IDH1/2 wild-type glioblastoma.Image guidance in malignant gliomas: a focused strategy.

P2860

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P2860

PARP inhibition sensitizes childhood high grade glioma, medulloblastoma and ependymoma to radiation.

http://www.wikidata.org/entity/Q39425287

description

2011 nî lūn-bûn

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2011年の論文

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2011年学术文章

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2011年学术文章

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2011年学术文章

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2011年学术文章

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2011年学术文章

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2011年學術文章

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2011年學術文章

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2011年學術文章

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name

PARP inhibition sensitizes chi ...... a and ependymoma to radiation.

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PARP inhibition sensitizes chi ...... a and ependymoma to radiation.

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type

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PARP inhibition sensitizes chi ...... a and ependymoma to radiation.

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PARP inhibition sensitizes chi ...... a and ependymoma to radiation.

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PARP inhibition sensitizes chi ...... a and ependymoma to radiation.

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PARP inhibition sensitizes chi ...... a and ependymoma to radiation.

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PARP inhibition sensitizes chi ...... ma and ependymoma to radiation

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David P Noske

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Esther Hulleman

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Gertjan J L Kaspers

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Hendrik Witt

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Jacqueline Cloos

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Laurine E Wedekind

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Marcel Kool

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Olga L M Meijer

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Peter W Vandertop

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Thomas Würdinger

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P2860

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

The 2007 WHO classification of tumours of the central nervous system

Subtypes of medulloblastoma have distinct developmental origins

Molecular and phenotypic characterisation of paediatric glioma cell lines as models for preclinical drug development

Essential role for nuclear PTEN in maintaining chromosomal integrity

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial

PARP inhibition: PARP1 and beyond

Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial

Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features.

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984-996

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12

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2

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Dannis G van Vuurden

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51902566

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22184287

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medulloblastoma

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3282104

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