Improving the efficiency of CHO cell line generation using glutamine synthetase gene knockout cells.
about
P1343
Recent advances in mammalian protein productionTherapeutic bispecific T-cell engager antibody targeting the intracellular oncoprotein WT1.Zinc finger nuclease mediated knockout of ADP-dependent glucokinase in cancer cell lines: effects on cell survival and mitochondrial oxidative metabolism.Quantifying genome-editing outcomes at endogenous loci with SMRT sequencing.Identification and characterization of a -1 reading frameshift in the heavy chain constant region of an IgG1 recombinant monoclonal antibody produced in CHO cellsAdvances in Mammalian cell line development technologies for recombinant protein production.Precision genome editing: a small revolution for glycobiology.Comparative study of therapeutic antibody candidates derived from mini-pool and clonal cell lines.Leveraging a CHO cell line toolkit to accelerate biotherapeutics into the clinic.New Mammalian Expression Systems.Application of CRISPR/Cas9 Genome Editing to Improve Recombinant Protein Production in CHO Cells.High-throughput screening and selection of mammalian cells for enhanced protein production.CHO cells knocked out for TSC2 display an improved productivity of antibodies under fed batch conditions.A high cell density transient transfection system for therapeutic protein expression based on a CHO GS-knockout cell line: process development and product quality assessment.A Systematic Approach to Time-series Metabolite Profiling and RNA-seq Analysis of Chinese Hamster Ovary Cell CultureHigh-throughput mAb expression and purification platform based on transient CHO.Complete knockout of the lactate dehydrogenase A gene is lethal in pyruvate dehydrogenase kinase 1, 2, 3 down-regulated CHO cells.Using Gene Essentiality and Synthetic Lethality Information to Correct Yeast and CHO Cell Genome-Scale Models.mTORC1 signalling and eIF4E/4E-BP1 translation initiation factor stoichiometry influence recombinant protein productivity from GS-CHOK1 cells.Bioreactor scale up and protein product quality characterization of piggyBac transposon derived CHO pools.Transient and stable CHO expression, purification and characterization of novel hetero-dimeric bispecific IgG antibodies.Intracellular response to process optimization and impact on productivity and product aggregates for a high-titer CHO cell process.Generation of stable Chinese hamster ovary pools yielding antibody titers of up to 7.6 g/L using the piggyBac transposon system.Comparative Proteomic Analysis of Three Chinese Hamster Ovary (CHO) Host Cells.Optimized Selection Marker and CHO Host Cell Combinations for Generating High Monoclonal Antibody Producing Cell Lines.Comprehensive characterization of glutamine synthetase-mediated selection for the establishment of recombinant CHO cells producing monoclonal antibodies.
P2860
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P2860
Improving the efficiency of CHO cell line generation using glutamine synthetase gene knockout cells.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
2011年學術文章
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2011年學術文章
@zh-hant
name
Improving the efficiency of CH ...... ynthetase gene knockout cells.
@en
Improving the efficiency of CH ...... ynthetase gene knockout cells.
@nl
type
label
Improving the efficiency of CH ...... ynthetase gene knockout cells.
@en
Improving the efficiency of CH ...... ynthetase gene knockout cells.
@nl
prefLabel
Improving the efficiency of CH ...... ynthetase gene knockout cells.
@en
Improving the efficiency of CH ...... ynthetase gene knockout cells.
@nl
P2093
P2860
P356
P1476
Improving the efficiency of CH ...... ynthetase gene knockout cells.
@en
P2093
Christopher C Frye
Christopher C Hatfield
Ibrahim Kadura
Lara E Krebs
Lianchun Fan
Margaret M Shaw
P2860
P304
P356
10.1002/BIT.24365
P4510
P577
2011-11-21T00:00:00Z