The netrin-1 receptor DCC promotes filopodia formation and cell spreading by activating Cdc42 and Rac1.
about
Signaling from axon guidance receptorsUNC-6/netrin and its receptors UNC-5 and UNC-40/DCC modulate growth cone protrusion in vivo in C. elegansOptogenetic activation of axon guidance receptors controls direction of neurite outgrowthUNC-40/DCC, SAX-3/Robo, and VAB-1/Eph polarize F-actin during embryonic morphogenesis by regulating the WAVE/SCAR actin nucleation complexThe Rac GTP exchange factor TIAM-1 acts with CDC-42 and the guidance receptor UNC-40/DCC in neuronal protrusion and axon guidanceQuantification of expression of netrins, slits and their receptors in human prostate tumorsFocal adhesion kinase in netrin-1 signalingNetrin-1 and its receptors in tumorigenesisSoluble adenylyl cyclase is required for netrin-1 signaling in nerve growth conesAutocrine netrin function inhibits glioma cell motility and promotes focal adhesion formationp120RasGAP Protein Mediates Netrin-1 Protein-induced Cortical Axon Outgrowth and Guidance.The adaptor protein Nck-1 couples the netrin-1 receptor DCC (deleted in colorectal cancer) to the activation of the small GTPase Rac1 through an atypical mechanism.Netrin signal transduction and the guanine nucleotide exchange factor DOCK180 in attractive signaling.Trio is a key guanine nucleotide exchange factor coordinating regulation of the migration and morphogenesis of granule cells in the developing cerebellum.Differential regulation of myosin X movements by its cargos, DCC and neogenin.A critical role for STIM1 in filopodial calcium entry and axon guidance.The UNC-6/Netrin receptors UNC-40/DCC and UNC-5 inhibit growth cone filopodial protrusion via UNC-73/Trio, Rac-like GTPases and UNC-33/CRMP.A requirement for filopodia extension toward Slit during Robo-mediated axon repulsionIn the absence of frazzled over-expression of Abelson tyrosine kinase disrupts commissure formation and causes axons to leave the embryonic CNS.Netrin-1 controls sympathetic arterial innervation.Axon guidance: asymmetric signaling orients polarized outgrowth.Pioneer midbrain longitudinal axons navigate using a balance of Netrin attraction and Slit repulsion.Netrin-1 induces MMP-12-dependent E-cadherin degradation via the distinct activation of PKCĪ± and FAK/Fyn in promoting mesenchymal stem cell motility.Netrin requires focal adhesion kinase and Src family kinases for axon outgrowth and attractionActivation of FAK and Src are receptor-proximal events required for netrin signalingDifferential colorectal carcinogenesis: Molecular basis and clinical relevanceInhibition of HSV-1 Replication by Gene Editing StrategyIdentification of a DOCK180-related guanine nucleotide exchange factor that is capable of mediating a positive feedback activation of Cdc42.The growth cone cytoskeleton in axon outgrowth and guidance.VAB-8, UNC-73 and MIG-2 regulate axon polarity and cell migration functions of UNC-40 in C. elegans.Roles for netrin signaling outside of axon guidance: a view from the wormAnchoring of protein kinase A by ERM (ezrin-radixin-moesin) proteins is required for proper netrin signaling through DCC (deleted in colorectal cancer)Netrins and Frazzled/DCC promote the migration and mesenchymal to epithelial transition of Drosophila midgut cells.The activation of ezrin-radixin-moesin proteins is regulated by netrin-1 through Src kinase and RhoA/Rho kinase activities and mediates netrin-1-induced axon outgrowth.Glypican Is a Modulator of Netrin-Mediated Axon GuidanceBrain meets pancreas: netrin, an axon guidance molecule, controls epithelial cell migration.Netrin instructs synaptic vesicle clustering through Rac GTPase, MIG-10, and the actin cytoskeleton.Hsc70 chaperone activity underlies Trio GEF function in axon growth and guidance induced by netrin-1.p130CAS is required for netrin signaling and commissural axon guidance.Axon guidance at the midline: from mutants to mechanisms.
P2860
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P2860
The netrin-1 receptor DCC promotes filopodia formation and cell spreading by activating Cdc42 and Rac1.
description
2002 nĆ® lÅ«n-bĆ»n
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2002幓ć®č«ę
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2002幓å¦ęÆęē«
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2002幓å¦ęÆęē«
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2002幓å¦ęÆęē«
@zh-hans
2002幓å¦ęÆęē«
@zh-my
2002幓å¦ęÆęē«
@zh-sg
2002幓åøč”ęē«
@yue
2002幓åøč”ęē«
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@zh-hant
name
The netrin-1 receptor DCC prom ...... by activating Cdc42 and Rac1.
@en
The netrin-1 receptor DCC prom ...... by activating Cdc42 and Rac1.
@nl
type
label
The netrin-1 receptor DCC prom ...... by activating Cdc42 and Rac1.
@en
The netrin-1 receptor DCC prom ...... by activating Cdc42 and Rac1.
@nl
prefLabel
The netrin-1 receptor DCC prom ...... by activating Cdc42 and Rac1.
@en
The netrin-1 receptor DCC prom ...... by activating Cdc42 and Rac1.
@nl
P356
P1476
The netrin-1 receptor DCC prom ...... by activating Cdc42 and Rac1.
@en
P2093
Masoud Shekarabi
Timothy E Kennedy
P356
10.1006/MCNE.2001.1075
P577
2002-01-01T00:00:00Z