Transgenic expression and activation of PGC-1α protect dopaminergic neurons in the MPTP mouse model of Parkinson's disease. - Wikidata - awgldk - TriplyDB

Transgenic expression and activation of PGC-1α protect dopaminergic neurons in the MPTP mouse model of Parkinson's disease.

Transgenic expression and activation of PGC-1α protect dopaminergic neurons in the MPTP mouse model of Parkinson's disease.

http://www.wikidata.org/entity/Q39460847

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Fibroblast growth factor-21 (FGF21) regulates low-density lipoprotein receptor (LDLR) levels in cells via the E3-ubiquitin ligase Mylip/Idol and the Canopy2 (Cnpy2)/Mylip-interacting saposin-like protein (Msap)Resveratrol and clinical trials: the crossroad from in vitro studies to human evidence Resveratrol and Ophthalmic Diseases Emerging preclinical pharmacological targets for Parkinson's disease Sirt1 and the Mitochondria Electron Transport Disturbances and Neurodegeneration: From Albert Szent-Györgyi's Concept (Szeged) till Novel Approaches to Boost Mitochondrial Bioenergetics Plant-derived neuroprotective agents in Parkinson's disease Mouse models of Parkinson's disease associated with mitochondrial dysfunction New insights into PGC-1 coactivators: redefining their role in the regulation of mitochondrial function and beyond After the banquet: mitochondrial biogenesis, mitophagy, and cell survival c-Abl Inhibitors Enable Insights into the Pathophysiology and Neuroprotection in Parkinson's Disease Anti-Oxidants in Parkinson's Disease Therapy: A Critical Point of View Mitochondrial dysfunction in neurodegenerative diseases PGC-1α negatively regulates extrasynaptic NMDAR activity and excitotoxicity Mitochondrial quality, dynamics and functional capacity in Parkinson's disease cybrid cell lines selected for Lewy body expression.Axon degeneration and PGC-1α-mediated protection in a zebrafish model of α-synuclein toxicity Cerebellar transcriptional alterations with Purkinje cell dysfunction and loss in mice lacking PGC-1α.Radioprotective and antioxidant effect of resveratrol in hippocampus by activating Sirt1 Mitochondrial Effects of PGC-1alpha Silencing in MPP+ Treated Human SH-SY5Y Neuroblastoma Cells.SIRT1 ameliorates oxidative stress induced neural cell death and is down-regulated in Parkinson's disease.Agonism of the 5-hydroxytryptamine 1F receptor promotes mitochondrial biogenesis and recovery from acute kidney injury Gene expression profiles in Parkinson disease prefrontal cortex implicate FOXO1 and genes under its transcriptional regulation.Developmental alterations in motor coordination and medium spiny neuron markers in mice lacking pgc-1α Pgc-1α overexpression downregulates Pitx3 and increases susceptibility to MPTP toxicity associated with decreased Bdnf.Nuclear receptors in neurodegenerative diseases.Complex network-driven view of genomic mechanisms underlying Parkinson's disease: analyses in dorsal motor vagal nucleus, locus coeruleus, and substantia nigra Mutual exacerbation of peroxisome proliferator-activated receptor γ coactivator 1α deregulation and α-synuclein oligomerization Somatic mitochondrial DNA mutations do not increase neuronal vulnerability to MPTP in young POLG mutator mice.SIRT1 in the brain-connections with aging-associated disorders and lifespan PGC-1α activity in nigral dopamine neurons determines vulnerability to α-synuclein Fibroblast growth factor-21 enhances mitochondrial functions and increases the activity of PGC-1α in human dopaminergic neurons via Sirtuin-1.PGC-1α Promoter Methylation in Parkinson's Disease EGCG-mediated autophagy flux has a neuroprotection effect via a class III histone deacetylase in primary neuron cells.Resveratrol Protects PC12 Cell against 6-OHDA Damage via CXCR4 Signaling Pathway.Polydatin Alleviates Small Intestine Injury during Hemorrhagic Shock as a SIRT1 Activator.Cell survival and differentiation with nanocrystalline glass-like carbon using substantia nigra dopaminergic cells derived from transgenic mouse embryos Thiol-redox signaling, dopaminergic cell death, and Parkinson's disease Are sirtuins viable targets for improving healthspan and lifespan?Promotion of mitochondrial biogenesis by necdin protects neurons against mitochondrial insults.A Feed-Forward Circuit of Endogenous PGC-1α and Estrogen Related Receptor α Regulates the Neuronal Electron Transport Chain

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Transgenic expression and activation of PGC-1α protect dopaminergic neurons in the MPTP mouse model of Parkinson's disease.

http://www.wikidata.org/entity/Q39460847

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2011年论文

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Transgenic expression and acti ...... model of Parkinson's disease.

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Transgenic expression and acti ...... model of Parkinson's disease.

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Transgenic expression and acti ...... model of Parkinson's disease.

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Transgenic expression and acti ...... model of Parkinson's disease.

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Cellular and Molecular Life Sciences

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Transgenic expression and acti ...... model of Parkinson's disease.

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Alessandra Bonomo

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Annika Mälkiä

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Dan Lindholm

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Giuseppa Mudò

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Johanna Mäkelä

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Jose A Aguirre

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Laura Korhonen

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Melania Olivieri

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Minna Kairisalo

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Natale Belluardo

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P2860

PGC-1α, a potential therapeutic target for early intervention in Parkinson's disease

Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha

Resveratrol pretreatment protects rat brain from cerebral ischemic damage via a sirtuin 1-uncoupling protein 2 pathway

Endoplasmic reticulum stress inhibition protects against excitotoxic neuronal injury in the rat brain

Localization of the transcriptional coactivator PGC-1alpha to GABAergic neurons during maturation of the rat brain

PGC-1{alpha} and PGC-1{beta} regulate mitochondrial density in neurons

SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis

Therapeutic potential of resveratrol: the in vivo evidence

Epidemiology of Parkinson's disease

Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators

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s00018-011-0850-z

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1153-1165

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scholarly article

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10.1007/S00018-011-0850-Z

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7

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69

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Valentina Di Liberto

Petteri Piepponen

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2011-10-08T00:00:00Z

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51704122

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21984601

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Parkinson's disease