Estrogen-dependent gene transcription in human breast cancer cells relies upon proteasome-dependent monoubiquitination of histone H2B.
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Global histone post-translational modifications and cancer: Biomarkers for diagnosis, prognosis and treatment?Epigenetic plasticity: a central regulator of epithelial-to-mesenchymal transition in cancerUncovering the role of Sgf73 in maintaining SAGA deubiquitinating module structure and activity.Identification of novel human damage response proteins targeted through yeast orthology.Histones and their modifications in ovarian cancer - drivers of disease and therapeutic targets.Ubiquitylation of nuclear receptors: new linkages and therapeutic implications.Microarray Analysis Reveals Potential Biological Functions of Histone H2B Monoubiquitination.H4K12ac is regulated by estrogen receptor-alpha and is associated with BRD4 function and inducible transcription.Histone ubiquitination and deubiquitination in transcription, DNA damage response, and cancer.RNF20 and USP44 regulate stem cell differentiation by modulating H2B monoubiquitylation.Ctr9, a key subunit of PAFc, affects global estrogen signaling and drives ERα-positive breast tumorigenesis.The Mediator subunit MED23 couples H2B mono-ubiquitination to transcriptional control and cell fate determination.Usp22 deficiency impairs intestinal epithelial lineage specification in vivoBromodomain protein BRD4 is required for estrogen receptor-dependent enhancer activation and gene transcriptionRNF20 Links Histone H2B Ubiquitylation with Inflammation and Inflammation-Associated CancerDecreased histone H2B monoubiquitination in malignant gastric carcinoma.Post-translational regulation of the cleaved fragment of Par-4 in ovarian and endometrial cancer cells.Histone H2B mono-ubiquitylation maintains genomic integrity at stalled replication forks.Epithelial to mesenchymal transition in the pathogenesis of uterine malignant mixed Müllerian tumours: the role of ubiquitin proteasome system and therapeutic opportunities.The enigmatic role of H2Bub1 in cancer.Regulation of chromatin structure via histone post-translational modification and the link to carcinogenesis.USP44 Is an Integral Component of N-CoR that Contributes to Gene Repression by Deubiquitinating Histone H2B.The RING finger domain E3 ubiquitin ligases BRCA1 and the RNF20/RNF40 complex in global loss of the chromatin mark histone H2B monoubiquitination (H2Bub1) in cell line models and primary high-grade serous ovarian cancer.SUPT6H controls estrogen receptor activity and cellular differentiation by multiple epigenomic mechanisms.The oncogenic polycomb histone methyltransferase EZH2 methylates lysine 120 on histone H2B and competes ubiquitination.The Emerging Role of Non-traditional Ubiquitination in Oncogenic Pathways.Phosphorylation by cyclin-dependent kinase-9 controls ubiquitin-conjugating enzyme-2A function.Histone Chaperone SSRP1 is Essential for Wnt Signaling Pathway Activity During Osteoblast Differentiation.Loss of H2Bub1 Expression is Linked to Poor Prognosis in Nodal Negative Colorectal Cancers.Histone deacetylase class-I inhibition promotes epithelial gene expression in pancreatic cancer cells in a BRD4- and MYC-dependent manner.Cohesin is required for expression of the estrogen receptor-alpha (ESR1) gene.Krüppel-like Transcription Factor KLF10 Suppresses TGFβ-Induced Epithelial-to-Mesenchymal Transition via a Negative Feedback MechanismRNF20 and histone H2B ubiquitylation exert opposing effects in Basal-Like versus luminal breast cancer.Chemo-Genetic Interactions Between Histone Modification and the Antiproliferation Drug AICAR Are Conserved in Yeast and Humans.let-7b and let-7c microRNAs promote histone H2B ubiquitylation and inhibit cell migration by targeting multiple components of the H2B deubiquitylation machinery.Ubiquitin Specific Peptidase 22 Regulates Histone H2B Mono-Ubiquitination and Exhibits Both Oncogenic and Tumor Suppressor Roles in Cancer.Loss of H2B monoubiquitination is associated with poor-differentiation and enhanced malignancy of lung adenocarcinoma.The ubiquitin-specific protease USP36 is a conserved histone H2B deubiquitinase.Role of novel histone modifications in cancer.Targeting USP22 Suppresses Tumorigenicity and Enhances Cisplatin Sensitivity Through ALDH1A3 Downregulation in Cancer-initiating Cells from Lung Adenocarcinoma.
P2860
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P2860
Estrogen-dependent gene transcription in human breast cancer cells relies upon proteasome-dependent monoubiquitination of histone H2B.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
2011年學術文章
@zh
2011年學術文章
@zh-hant
name
Estrogen-dependent gene transc ...... ubiquitination of histone H2B.
@en
Estrogen-dependent gene transc ...... ubiquitination of histone H2B.
@nl
type
label
Estrogen-dependent gene transc ...... ubiquitination of histone H2B.
@en
Estrogen-dependent gene transc ...... ubiquitination of histone H2B.
@nl
prefLabel
Estrogen-dependent gene transc ...... ubiquitination of histone H2B.
@en
Estrogen-dependent gene transc ...... ubiquitination of histone H2B.
@nl
P2093
P50
P1433
P1476
Estrogen-dependent gene transc ...... ubiquitination of histone H2B.
@en
P2093
Corinna Hintermair
Elisabeth Kremmer
Frank Kramer
Tanja Prenzel
Theresa Gorsler
Tim Beissbarth
P304
P356
10.1158/0008-5472.CAN-11-1896
P407
P577
2011-08-23T00:00:00Z