The transcription factor FOXM1 is a cellular target of the natural product thiostrepton.
about
Cyclisation mechanisms in the biosynthesis of ribosomally synthesised and post-translationally modified peptidesThiopeptide antibiotics: retrospective and recent advancesFOXM1: an emerging master regulator of DNA damage response and genotoxic agent resistanceExpanding the number of 'druggable' targets: non-enzymes and protein-protein interactionsDisabling Mitochondrial Peroxide Metabolism via Combinatorial Targeting of Peroxiredoxin 3 as an Effective Therapeutic Approach for Malignant MesotheliomaThioFinder: a web-based tool for the identification of thiopeptide gene clusters in DNA sequencesFOXM1 is an oncogenic mediator in Ewing SarcomaPeroxiredoxin 3 is a redox-dependent target of thiostrepton in malignant mesothelioma cellsIdentification of neuron selective androgen receptor inhibitors.Prognostic value of FOXM1 in solid tumors: a systematic review and meta-analysis.MELK is an oncogenic kinase essential for mitotic progression in basal-like breast cancer cells.Binding induced RNA conformational changes control substrate recognition and catalysis by the thiostrepton resistance methyltransferase (Tsr).Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature.Down-regulation of FoxM1 by thiostrepton or small interfering RNA inhibits proliferation, transformation ability and angiogenesis, and induces apoptosis of nasopharyngeal carcinoma cells.Overexpression of FOXM1 is associated with metastases of nasopharyngeal carcinomaTranslational synthetic chemistry.Suppression of the FOXM1 transcriptional programme via novel small molecule inhibitionTargeting of mutant p53-induced FoxM1 with thiostrepton induces cytotoxicity and enhances carboplatin sensitivity in cancer cellsIdentification of candidate B-lymphoma genes by cross-species gene expression profiling.ROS inhibitor N-acetyl-L-cysteine antagonizes the activity of proteasome inhibitorsIdentification of FOXM1 as a therapeutic target in B-cell lineage acute lymphoblastic leukaemia.Glioblastoma multiforme formation and EMT: role of FoxM1 transcription factorUnravelling the genomic targets of small molecules using high-throughput sequencing.A FOXM1 Dependent Mesenchymal-Epithelial Transition in Retinal Pigment Epithelium Cells.Combination with bortezomib enhances the antitumor effects of nanoparticle-encapsulated thiostrepton.MEIS2 is essential for neuroblastoma cell survival and proliferation by transcriptional control of M-phase progression.FoxM1 Directs STAT3 Expression Essential for Human Endometrial Stromal Decidualization.Thiostrepton interacts covalently with Rpt subunits of the 19S proteasome and proteasome substrates.Prognostic significance of FOXM1 expression and antitumor effect of FOXM1 inhibition in synovial sarcomasFOXM1 is overexpressed in B-acute lymphoblastic leukemia (B-ALL) and its inhibition sensitizes B-ALL cells to chemotherapeutic drugsFOXM1 is a downstream target of LPA and YAP oncogenic signaling pathways in high grade serous ovarian cancer.Expression of Forkhead box M1 in soft tissue leiomyosarcoma: Clinicopathologic and in vitro study using a newly established cell line.Novel functions of FoxM1: from molecular mechanisms to cancer therapyRecombinant thiopeptides containing noncanonical amino acids.Saturation mutagenesis of TsrA Ala4 unveils a highly mutable residue of thiostrepton A.FOXM1 is a therapeutic target for high-risk multiple myeloma.FOXM1 is a molecular determinant of the mitogenic and invasive phenotype of anaplastic thyroid carcinomaThiostrepton Variants Containing a Contracted Quinaldic Acid Macrocycle Result from Mutagenesis of the Second Residue.Genome-wide mapping of FOXM1 binding reveals co-binding with estrogen receptor alpha in breast cancer cells.Englerin A Inhibits EWS-FLI1 DNA Binding in Ewing Sarcoma Cells
P2860
Q26738949-C85B8252-4E5D-4E50-8A40-782A6F78B1F2Q26852567-EB63B1E1-B945-4EE7-B935-C9AEA01D9A0BQ26864654-0103D103-46C1-4C26-A5DF-3CEC65E38952Q27003966-B569B193-7954-4F25-A619-B18A435F67E4Q27306784-44B20A66-972B-4F0A-A0E9-E5B420754757Q28483962-E9F023A2-38FD-4024-9F15-51DAC7BC84EDQ28485291-415D14BE-CF89-4126-9893-4CA1E43F1F59Q28728015-DFD753FA-70FB-493C-810F-D5E43366097DQ33711488-14B55D7A-CA0E-44A1-8CC3-9D0A5D7632A3Q33762091-998608C5-4970-4951-87E9-272BB20E735BQ33762222-9150CFD6-8D75-4602-8775-9F6CB32A92BCQ34249082-06EA5D52-AA87-4264-823B-21C0D6D80AF8Q34312732-116095F1-C03F-4372-B1D7-E06FB81C77AAQ34371119-FAE0BECE-CCFF-4F7C-8018-9607D5FEB550Q34589178-C05E96AA-D22C-47D1-9F81-F100F3AB5684Q34626958-FA66E279-795A-46A8-A340-209EAE24D8FCQ34649774-9DE9A653-CFD5-4D04-AD46-5141A0EA520CQ34956879-45D0B579-7C10-43AC-986D-F0B25FFDCB26Q35018604-4070DF63-6D00-4546-BC63-BAF3B1DCE6E9Q35065984-5B39A76E-1C32-4598-B195-11ABB17F2631Q35197045-BF159AA5-F723-4236-BC81-BAF652612BD5Q35234273-37EB8A7B-C53C-4713-A976-038C89A1A23CQ35328171-25026F84-C5A0-428C-A2D2-12BF1343C57DQ35677149-CF6D9F77-F35A-4AE1-9C57-C20BBF549B52Q35911674-E70631FA-3BE8-4E24-A069-6AF4726D34DAQ35966255-13D8ABEE-29E1-4A71-B4EA-BDD9888A00CBQ36022421-5AE4448D-00E1-4B28-A95F-51100929F14AQ36057485-29062B97-CD82-4014-9514-B3CB419D0584Q36083264-58253E6B-C2BC-4845-B259-E40CB963A789Q36094104-EA77A9CD-4A9F-4829-B5BC-73F16BF9E3CEQ36413873-390E8E02-EC72-453D-BBC1-FF50C78BBD39Q36495922-FB9EE6FE-CBF0-4AC1-9B86-A9D7ACE59A80Q36657633-AD3A70C2-9D24-40E4-B970-8F8F01BB72B0Q36770573-6881EC7D-AF5B-4D3F-8ADE-568DD60048F1Q36781888-3C7F74C8-7233-4490-8248-A3975E98AAA9Q36783627-B69E6AB5-6D0D-456B-AB4C-47C14276E374Q36799818-C27FBFC2-1C03-4F8F-A76E-470FBF0F82D9Q36843584-8AF2AD31-B326-4F9D-A6AA-8960857699B9Q36872440-631C73A8-D6FA-4A79-B1D2-5B54CAEE74C7Q36876146-51A91993-7D98-4C38-80DA-96E17E6A77EF
P2860
The transcription factor FOXM1 is a cellular target of the natural product thiostrepton.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
2011年學術文章
@zh
2011年學術文章
@zh-hant
name
The transcription factor FOXM1 is a cellular target of the natural product thiostrepton.
@en
The transcription factor FOXM1 is a cellular target of the natural product thiostrepton.
@nl
type
label
The transcription factor FOXM1 is a cellular target of the natural product thiostrepton.
@en
The transcription factor FOXM1 is a cellular target of the natural product thiostrepton.
@nl
prefLabel
The transcription factor FOXM1 is a cellular target of the natural product thiostrepton.
@en
The transcription factor FOXM1 is a cellular target of the natural product thiostrepton.
@nl
P2093
P2860
P356
P1433
P1476
The transcription factor FOXM1 is a cellular target of the natural product thiostrepton.
@en
P2093
Deborah A Sanders
Nagaratna S Hegde
Shankar Balasubramanian
P2860
P2888
P304
P356
10.1038/NCHEM.1114
P577
2011-08-21T00:00:00Z
P5875
P6179
1031719828