Rhein reverses the diabetic phenotype of mesangial cells over-expressing the glucose transporter (GLUT1) by inhibiting the hexosamine pathway.
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Molecular mechanisms of diabetic retinopathy, general preventive strategies, and novel therapeutic targetsA Comprehensive and System Review for the Pharmacological Mechanism of Action of Rhein, an Active Anthraquinone IngredientDiabetic Kidney Disease: Pathophysiology and Therapeutic TargetsDiabetic nephropathy research in China: Data analysis and review from the National Natural Science Foundation of China.Isoproterenol-induced FKBP12.6/12 downregulation is modulated by ETA and ETB receptors and reversed by argirhein, a derivative of rheinObesity-related glomerulopathy: body mass index and proteinuria.Pharmacokinetics of anthraquinones in rat plasma after oral administration of a rhubarb extract.Toll-like receptor 4 is involved in a protective effect of rhein on immunoglobulin A nephropathyRhein prevents endotoxin-induced acute kidney injury by inhibiting NF-κB activitiesThe Inhibitory Effect of Rhein on Proliferation of High Glucose-induced Mesangial Cell Through Cell Cycle Regulation and Induction of Cell Apoptosis.Hyperglycemia Induces Skin Barrier Dysfunctions with Impairment of Epidermal Integrity in Non-Wounded Skin of Type 1 Diabetic Mice.Protection of rhein on IgA nephropathy mediated by inhibition of fibronectin expression in ratsHistone Lysine Methylation in TGF-β1 Mediated p21 Gene Expression in Rat Mesangial Cells.Rhein protects pancreatic β-cells from dynamin-related protein-1-mediated mitochondrial fission and cell apoptosis under hyperglycemiaTherapeutic use of traditional Chinese herbal medications for chronic kidney diseasesAntifibrotic treatment and other new strategies for improving renal outcomesThe molecular mechanism of rhein in diabetic nephropathy.Involvement of Histone Lysine Methylation in p21 Gene Expression in Rat Kidney In Vivo and Rat Mesangial Cells In Vitro under Diabetic Conditions.Improvement of glucose tolerance by rhein with restored early-phase insulin secretion in db/db mice.Effects of Free Anthraquinones Extract from the Rhubarb on Cell Proliferation and Accumulation of Extracellular Matrix in High Glucose Cultured-Mesangial Cells.Rhein, an inhibitor of adipocyte differentiation and adipogenesis.Evaluation of antidiabetic potential of oyster mushroom (Pleurotus ostreatus) in alloxan-induced diabetic mice.Gut flora may offer new therapeutic targets for the traditional Chinese medicine enteric dialysis.Argirein alleviates diabetic nephropathy through attenuating NADPH oxidase, Cx43, and PERK in renal tissue.Kidney-targeted drug delivery via rhein-loaded polyethyleneglycol-co-polycaprolactone-co-polyethylenimine nanoparticles for diabetic nephropathy therapy.Gut Microbiota Play an Essential Role in the Antidiabetic Effects of RheinPrediction of Human Pharmacokinetics from Preclinical Information of Rhein, an Antidiabetic Nephropathy Drug, Using a Physiologically Based Pharmacokinetic Model
P2860
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P2860
Rhein reverses the diabetic phenotype of mesangial cells over-expressing the glucose transporter (GLUT1) by inhibiting the hexosamine pathway.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Rhein reverses the diabetic ph ...... biting the hexosamine pathway.
@en
Rhein reverses the diabetic ph ...... essing the glucose transporter
@nl
type
label
Rhein reverses the diabetic ph ...... biting the hexosamine pathway.
@en
Rhein reverses the diabetic ph ...... essing the glucose transporter
@nl
prefLabel
Rhein reverses the diabetic ph ...... biting the hexosamine pathway.
@en
Rhein reverses the diabetic ph ...... essing the glucose transporter
@nl
P2093
P2860
P356
P1476
Rhein reverses the diabetic ph ...... biting the hexosamine pathway.
@en
P2093
P2860
P304
P356
10.1038/BJP.2008.26
P407
P577
2008-02-11T00:00:00Z