about
Clinical Outlook for Type-1 and FOXP3(+) T Regulatory Cell-Based TherapyDefective regulatory and effector T cell functions in patients with FOXP3 mutations.Autoantibodies to harmonin and villin are diagnostic markers in children with IPEX syndrome.Fatal autoimmunity in mice reconstituted with human hematopoietic stem cells encoding defective FOXP3Demethylation analysis of the FOXP3 locus shows quantitative defects of regulatory T cells in IPEX-like syndrome.Immune dysregulation, polyendocrinopathy, enteropathy, x-linked syndrome: a paradigm of immunodeficiency with autoimmunityCombined DOCK8 and CLEC7A mutations causing immunodeficiency in 3 brothers with diarrhea, eczema, and infections.Accumulation of peripheral autoreactive B cells in the absence of functional human regulatory T cells.Forkhead box P3: the peacekeeper of the immune system.CD4⁺ T cells from IPEX patients convert into functional and stable regulatory T cells by FOXP3 gene transfer.Regulated and multiple miRNA and siRNA delivery into primary cells by a lentiviral platform.STAT5-signaling cytokines regulate the expression of FOXP3 in CD4+CD25+ regulatory T cells and CD4+CD25- effector T cells.HIV-1-mediated insertional activation of STAT5B and BACH2 trigger viral reservoir in T regulatory cells.Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production.The role of 2 FOXP3 isoforms in the generation of human CD4+ Tregs.Forkhead-Box-P3 Gene Transfer in Human CD4+ T Conventional Cells for the Generation of Stable and Efficient Regulatory T Cells, Suitable for Immune Modulatory Therapy.Functional type 1 regulatory T cells develop regardless of FOXP3 mutations in patients with IPEX syndrome.Human in vitro induced T regulatory cells and memory T cells share common demethylation of specific FOXP3 promoter region.Point mutants of forkhead box P3 that cause immune dysregulation, polyendocrinopathy, enteropathy, X-linked have diverse abilities to reprogram T cells into regulatory T cells.Ectopic FOXP3 Expression Preserves Primitive Features Of Human Hematopoietic Stem Cells While Impairing Functional T Cell Differentiation.Wild-type FOXP3 is selectively active in CD4+CD25(hi) regulatory T cells of healthy female carriers of different FOXP3 mutations.Clinical and molecular profile of a new series of patients with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome: inconsistent correlation between forkhead box protein 3 expression and disease severity.Monitoring T-Cell Responses in Translational Studies: Optimization of Dye-Based Proliferation Assay for Evaluation of Antigen-Specific Responses.Role of human FOXP3 in early thymic maturation and peripheral T cell homeostasis.Expression of transforming growth factor-beta1 in thymus of myasthenia gravis patients: correlation with pathological abnormalities.Analysis of SjTREC levels in thymus from MG patients and normal children.Corrigendum: Monitoring T-Cell Responses in Translational Studies: Optimization of Dye-Based Proliferation Assay for Evaluation of Antigen-Specific Responses.Forkhead box protein 3 (FOXP3) mutations lead to increased TH17 cell numbers and regulatory T-cell instabilityIsolation, Expansion, and Characterization of Human Natural and Adaptive Regulatory T CellsFibrogenic cytokines and extent of fibrosis in muscle of dogs with X-linked golden retriever muscular dystrophyTargeting a Pre-existing Anti-transgene T Cell Response for Effective Gene Therapy of MPS-I in the Mouse Model of the DiseaseTreatment with rapamycin can restore regulatory T-cell function in IPEX patientsCRISPR-based gene editing enables FOXP3 gene repair in IPEX patient cells
P50
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P50
description
hulumtuese
@sq
researcher
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wetenschapper
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հետազոտող
@hy
name
Laura Passerini
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Laura Passerini
@en
Laura Passerini
@es
Laura Passerini
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Laura Passerini
@sl
type
label
Laura Passerini
@ast
Laura Passerini
@en
Laura Passerini
@es
Laura Passerini
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Laura Passerini
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prefLabel
Laura Passerini
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Laura Passerini
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Laura Passerini
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Laura Passerini
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Laura Passerini
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P108
P1053
J-7791-2016
P106
P1153
36010058800
P21
P31
P3829
P496
0000-0002-4020-7386