The Discovery of VX-745: A Novel and Selective p38α Kinase Inhibitor.

The Discovery of VX-745: A Novel and Selective p38α Kinase Inhibitor.

Item
http://www.wikidata.org/entity/Q39510138
Development of Novel In Vivo Chemical Probes to Address CNS Protein Kinase Involvement in Synaptic DysfunctionSelective Brain-Targeted Antagonism of p38 MAPKα Reduces Hippocampal IL-1β Levels and Improves Morris Water Maze Performance in Aged RatsDifferential Effects of p38, MAPK, PI3K or Rho Kinase Inhibitors on Bacterial Phagocytosis and Efferocytosis by Macrophages in COPD.The use of novel selectivity metrics in kinase research.p38α regulates actin cytoskeleton and cytokinesis in hepatocytes during development and agingA Comprehensive Structural Overview of p38α MAPK in Complex with Type I Inhibitors.Kinase targets in CNS drug discovery.Interferon-β counter-regulates its own pro-apoptotic action by activating p38 MAPK signalling in human SH-SY5Y neuroblastoma cells.Emerging treatments for Alzheimer's disease for non-amyloid and non-tau targets.Protection from interferon-β-induced neuronal apoptosis through stimulation of muscarinic acetylcholine receptors coupled to ERK1/2 activation.Diaminopyridine-based potent and selective mps1 kinase inhibitors binding to an unusual flipped-Peptide conformationSynthetic phosphorylation of p38α recapitulates protein kinase activityAn exploratory clinical study of p38α kinase inhibition in Alzheimer's disease.
P2860

The Discovery of VX-745: A Novel and Selective p38α Kinase Inhibitor.

Item
http://www.wikidata.org/entity/Q39510138
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
The Discovery of VX-745: A Novel and Selective p38α Kinase Inhibitor.
@en
The Discovery of VX-745: A Novel and Selective p38α Kinase Inhibitor.
@nl
type
label
The Discovery of VX-745: A Novel and Selective p38α Kinase Inhibitor.
@en
The Discovery of VX-745: A Novel and Selective p38α Kinase Inhibitor.
@nl
prefLabel
The Discovery of VX-745: A Novel and Selective p38α Kinase Inhibitor.
@en
The Discovery of VX-745: A Novel and Selective p38α Kinase Inhibitor.
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P433
P478
P50
P577
P5875
P698
P932
P356
P1433
P1476
The Discovery of VX-745: A Novel and Selective p38α Kinase Inhibitor
@en
P2093
P2860
P304
P31
P356
P433
P478
P50
P577
P5875
P698
P932