The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction.
about
Mitochondrial dysregulation and glycolytic insufficiency functionally impair CD8 T cells infiltrating human renal cell carcinoma.Anabolism-Associated Mitochondrial Stasis Driving Lymphocyte Differentiation over Self-Renewal.Resolution of Cancer-Promoting Inflammation: A New Approach for Anticancer Therapy.Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity.A platform for high-throughput bioenergy production phenotype characterization in single cells.Immune checkpoints and their inhibition in cancer and infectious diseases.Enhancement of PSMA-Directed CAR Adoptive Immunotherapy by PD-1/PD-L1 Blockade.Filling the Tank: Keeping Antitumor T Cells Metabolically Fit for the Long Haul.Efficacy of PD-1 Blockade Is Potentiated by Metformin-Induced Reduction of Tumor Hypoxia.Obstacles Posed by the Tumor Microenvironment to T cell Activity: A Case for Synergistic Therapies.Mitochondria are the powerhouses of immunity.Engineering Chimeric Antigen Receptor T-Cells for Racing in Solid Tumors: Don't Forget the FuelMetabolic Cooperation and Competition in the Tumor Microenvironment: Implications for Therapy.Dysfunctional T cell metabolism in the tumor microenvironment.Reenergizing T cell anti-tumor immunity by harnessing immunometabolic checkpoints and machineries.Metabolic Instruction of Immunity.Mitochondrial Control and Guidance of Cellular Activities of T Cells.Biochemical Underpinnings of Immune Cell Metabolic Phenotypes.Metabolic and Epigenetic Coordination of T Cell and Macrophage Immunity.Targeting T cell metabolism to regulate T cell activation, differentiation and function in disease.Transcriptional and epigenetic regulation of T cell hyporesponsiveness.PGC-1 Coactivators: Shepherding the Mitochondrial Biogenesis of Tumors.Metabolic reprogramming in the tumour microenvironment: a hallmark shared by cancer cells and T lymphocytes.Metabolic Regulation of T Cell Longevity and Function in Tumor Immunotherapy.Metabolic orchestration of T lineage differentiation and function.Regulation of mTOR, Metabolic Fitness, and Effector Functions by Cytokines in Natural Killer Cells.Exploring Non-Metabolic Functions of Glycolytic Enzymes in Immunity.The diverse functions of the PD1 inhibitory pathway.Two is better than one: advances in pathogen-boosted immunotherapy and adoptive T-cell therapy.Antitumor T cell reconditioning: improving metabolic fitness for optimal cancer immunotherapy.The spectrum of T cell metabolism in health and disease.CD38-NAD+Axis Regulates Immunotherapeutic Anti-Tumor T Cell Response.Early TCR Signaling Induces Rapid Aerobic Glycolysis Enabling Distinct Acute T Cell Effector Functions.Metabolic Barriers to T Cell Function in Tumors.Innate and Adaptive Immune Cell Metabolism in Tumor Microenvironment.Features of Effective T Cell-Inducing Vaccines against Chronic Viral Infections.Mitochondria-Endoplasmic Reticulum Contact Sites Function as Immunometabolic Hubs that Orchestrate the Rapid Recall Response of Memory CD8+ T Cells.Engineering Vaccines to Reprogram Immunity against Head and Neck Cancer.Metabolic Adaptations of CD4+ T Cells in Inflammatory Disease.IRE1α-XBP1 controls T cell function in ovarian cancer by regulating mitochondrial activity
P2860
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P2860
The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction.
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
2016年论文
@zh
2016年论文
@zh-cn
name
The Tumor Microenvironment Rep ...... Insufficiency and Dysfunction.
@en
The Tumor Microenvironment Rep ...... Insufficiency and Dysfunction.
@nl
type
label
The Tumor Microenvironment Rep ...... Insufficiency and Dysfunction.
@en
The Tumor Microenvironment Rep ...... Insufficiency and Dysfunction.
@nl
prefLabel
The Tumor Microenvironment Rep ...... Insufficiency and Dysfunction.
@en
The Tumor Microenvironment Rep ...... Insufficiency and Dysfunction.
@nl
P2093
P2860
P1433
P1476
The Tumor Microenvironment Rep ...... Insufficiency and Dysfunction.
@en
P2093
Ashley V Menk
Greg M Delgoffe
Rebecca S Moreci
Rebekah E Dadey
Robert L Ferris
Ryan D Whetstone
Simon C Watkins
P2860
P304
P356
10.1016/J.IMMUNI.2016.07.009
P407
P577
2016-08-02T00:00:00Z