Macrophage entry mediated by HIV Envs from brain and lymphoid tissues is determined by the capacity to use low CD4 levels and overall efficiency of fusion.
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HIV-1 envelope-receptor interactions required for macrophage infection and implications for current HIV-1 cure strategiesTargeting the Brain Reservoirs: Toward an HIV CureCompartmentalized human immunodeficiency virus type 1 originates from long-lived cells in some subjects with HIV-1-associated dementiaElite suppressor-derived HIV-1 envelope glycoproteins exhibit reduced entry efficiency and kineticsBioinformatic prediction programs underestimate the frequency of CXCR4 usage by R5X4 HIV type 1 in brain and other tissuesEvolution of the HIV-1 env gene in the Rag2-/- gammaC-/- humanized mouse modelLoss of asparagine-linked glycosylation sites in variable region 5 of human immunodeficiency virus type 1 envelope is associated with resistance to CD4 antibody ibalizumab.Genetic variation and HIV-associated neurologic disease.Adoption of an "open" envelope conformation facilitating CD4 binding and structural remodeling precedes coreceptor switch in R5 SHIV-infected macaques.Asn 362 in gp120 contributes to enhanced fusogenicity by CCR5-restricted HIV-1 envelope glycoprotein variants from patients with AIDS.HIV-1 replication in the central nervous system occurs in two distinct cell types.Emergence of CD4 independence envelopes and astrocyte infection in R5 simian-human immunodeficiency virus model of encephalitis.Single genome analysis reveals genetic characteristics of Neuroadaptation across HIV-1 envelope.Variation in the biological properties of HIV-1 R5 envelopes: implications of envelope structure, transmission and pathogenesis.Macrophages and their relevance in Human Immunodeficiency Virus Type I infection.HIVBrainSeqDB: a database of annotated HIV envelope sequences from brain and other anatomical sites.A machine learning approach for identifying amino acid signatures in the HIV env gene predictive of dementia.Central nervous system compartmentalization of HIV-1 subtype C variants early and late in infection in young childrenA conserved determinant in the V1 loop of HIV-1 modulates the V3 loop to prime low CD4 use and macrophage infection.Longitudinal Analysis of CCR5 and CXCR4 Usage in a Cohort of Antiretroviral Therapy-Naïve Subjects with Progressive HIV-1 Subtype C Infection.Conformational alterations in the CD4 binding cavity of HIV-1 gp120 influencing gp120-CD4 interactions and fusogenicity of HIV-1 envelopes derived from brain and other tissuesHIV-1 escape from the CCR5 antagonist maraviroc associated with an altered and less-efficient mechanism of gp120-CCR5 engagement that attenuates macrophage tropismHIV-1 target cells in the CNS.HIV-1 non-macrophage-tropic R5 envelope glycoproteins are not more tropic for entry into primary CD4+ T-cells than envelopes highly adapted for macrophages.Compartmentalized replication of R5 T cell-tropic HIV-1 in the central nervous system early in the course of infection.Alternative coreceptor requirements for efficient CCR5- and CXCR4-mediated HIV-1 entry into macrophages.CD4 and MHC class 1 down-modulation activities of nef alleles from brain- and lymphoid tissue-derived primary HIV-1 isolates.Viral determinants of HIV-1 macrophage tropism.Infection of ectocervical tissue and universal targeting of T-cells mediated by primary non-macrophage-tropic and highly macrophage-tropic HIV-1 R5 envelopes.Generation of transmitted/founder HIV-1 infectious molecular clones and characterization of their replication capacity in CD4 T lymphocytes and monocyte-derived macrophages.Longitudinal Analysis of Cerebrospinal Fluid and Plasma HIV-1 Envelope Sequences Isolated From a Single Donor with HIV Asymptomatic Neurocognitive Impairment.Independent evolution of macrophage-tropism and increased charge between HIV-1 R5 envelopes present in brain and immune tissue.HIV-1-related central nervous system disease: current issues in pathogenesis, diagnosis, and treatment.Although macrophage-tropic simian/human immunodeficiency viruses can exhibit a range of pathogenic phenotypes, a majority of isolates induce no clinical disease in immunocompetent macaques.Lineage-specific differences between human and simian immunodeficiency virus regulation of gp120 trimer association and CD4 bindingSaturation Mutagenesis of the HIV-1 Envelope CD4 Binding Loop Reveals Residues Controlling Distinct Trimer Conformations.When human immunodeficiency virus meets chemokines and microglia: neuroprotection or neurodegeneration?Phenotypic Correlates of HIV-1 Macrophage Tropism.Delineating CD4 dependency of HIV-1: Adaptation to infect low level CD4 expressing target cells widens cellular tropism but severely impacts on envelope functionality.Discordance in lymphoid tissue recovery following stem cell transplantation in rhesus macaques: an in vivo imaging study.
P2860
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P2860
Macrophage entry mediated by HIV Envs from brain and lymphoid tissues is determined by the capacity to use low CD4 levels and overall efficiency of fusion.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Macrophage entry mediated by H ...... overall efficiency of fusion.
@en
Macrophage entry mediated by H ...... overall efficiency of fusion.
@nl
type
label
Macrophage entry mediated by H ...... overall efficiency of fusion.
@en
Macrophage entry mediated by H ...... overall efficiency of fusion.
@nl
prefLabel
Macrophage entry mediated by H ...... overall efficiency of fusion.
@en
Macrophage entry mediated by H ...... overall efficiency of fusion.
@nl
P2093
P2860
P1433
P1476
Macrophage entry mediated by H ...... d overall efficiency of fusion
@en
P2093
Dana Gabuzda
Derek Bogdan
Elaine R Thomas
Jeanne E Bell
Jennifer Stanton
Joann Taylor
Kevin Kunstman
Rebecca L Dunfee
P2860
P304
P356
10.1016/J.VIROL.2006.09.036
P407
P577
2006-11-07T00:00:00Z