Novel effect of antihelminthic Niclosamide on S100A4-mediated metastatic progression in colon cancer. - Wikidata - awgldk - TriplyDB

Novel effect of antihelminthic Niclosamide on S100A4-mediated metastatic progression in colon cancer.

Novel effect of antihelminthic Niclosamide on S100A4-mediated metastatic progression in colon cancer.

http://www.wikidata.org/entity/Q39522017

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S100A4 in Cancer Metastasis: Wnt Signaling-Driven Interventions for Metastasis Restriction Niclosamide, an old antihelminthic agent, demonstrates antitumor activity by blocking multiple signaling pathways of cancer stem cells Damage-associated molecular patterns in cancer: a double-edged sword Niclosamide suppresses cancer cell growth by inducing Wnt co-receptor LRP6 degradation and inhibiting the Wnt/β-catenin pathway The anthelmintic drug niclosamide induces apoptosis, impairs metastasis and reduces immunosuppressive cells in breast cancer model A Novel High Content Imaging-Based Screen Identifies the Anti-Helminthic Niclosamide as an Inhibitor of Lysosome Anterograde Trafficking and Prostate Cancer Cell Invasion Niclosamide and its analogs are potent inhibitors of Wnt/β-catenin, mTOR and STAT3 signaling in ovarian cancer.Drug repositioning: a machine-learning approach through data integration.Epigenetic silencing of miR-520c leads to induced S100A4 expression and its mediated colorectal cancer progression Statin and rottlerin small-molecule inhibitors restrict colon cancer progression and metastasis via MACC1.Niclosamide is a potential therapeutic for familial adenomatosis polyposis by disrupting Axin-GSK3 interaction.Anti-helminthic niclosamide inhibits Ras-driven oncogenic transformation via activation of GSK-3 Multi-targeted therapy of cancer by niclosamide: A new application for an old drug.Small molecule modulators of Wnt/β-catenin signaling.Niclosamide ethanolamine-induced mild mitochondrial uncoupling improves diabetic symptoms in mice.WNT7A/β-catenin signaling induces FGF1 and influences sensitivity to niclosamide in ovarian cancer.Niclosamide inhibits androgen receptor variants expression and overcomes enzalutamide resistance in castration-resistant prostate cancer A multiplexed, targeted mass spectrometry assay of the S100 protein family uncovers the isoform-specific expression in thyroid tumours.High-throughput screening strategies for targeted identification of therapeutic compounds in colorectal cancer.Niclosamide suppresses migration of hepatocellular carcinoma cells and downregulates matrix metalloproteinase-9 expression.Systemic shRNA mediated knock down of S100A4 in colorectal cancer xenografted mice reduces metastasis formation.GPR55 promotes migration and adhesion of colon cancer cells indicating a role in metastasis.Structure-activity studies of Wnt/β-catenin inhibition in the Niclosamide chemotype: Identification of derivatives with improved drug exposure Niclosamide inhibits leaf blight caused by Xanthomonas oryzae in rice.Overexpression of S100A4 is closely associated with the progression and prognosis of gastric cancer in young patients Identification of approved and investigational drugs that inhibit hypoxia-inducible factor-1 signaling.Preclinical evaluation of a nanoformulated antihelminthic, niclosamide, in ovarian cancer.Functions of S100 proteins.Niclosamide inhibits colon cancer progression through downregulation of the Notch pathway and upregulation of the tumor suppressor miR-200 family.Niclosamide overcomes acquired resistance to erlotinib through suppression of STAT3 in non-small cell lung cancer.Niclosamide suppresses Hepatoma cell proliferation via the Wnt pathway S100A4 drives non-small cell lung cancer invasion, associates with poor prognosis, and is effectively targeted by the FDA-approved anti-helminthic agent niclosamide Comparative secretome analysis of epithelial and mesenchymal subpopulations of head and neck squamous cell carcinoma identifies S100A4 as a potential therapeutic target Niclosamide sensitizes triple-negative breast cancer cells to ionizing radiation in association with the inhibition of Wnt/β-catenin signaling.Effect of niclosamide on basal-like breast cancers.Niclosamide inhibition of STAT3 synergizes with erlotinib in human colon cancer.S100 proteins as diagnostic and prognostic markers in colorectal and hepatocellular carcinoma.Joining S100 proteins and migration: for better or for worse, in sickness and in health.The Simultaneous Inhibitory Effect of Niclosamide on RANKL-Induced Osteoclast Formation and Osteoblast Differentiation Niclosamide, an anti-helminthic molecule, downregulates the retroviral oncoprotein Tax and pro-survival Bcl-2 proteins in HTLV-1-transformed T lymphocytes.

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Novel effect of antihelminthic Niclosamide on S100A4-mediated metastatic progression in colon cancer.

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Novel effect of antihelminthic ...... c progression in colon cancer.

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Novel effect of antihelminthic ...... c progression in colon cancer.

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Novel effect of antihelminthic ...... c progression in colon cancer.

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Novel effect of antihelminthic ...... c progression in colon cancer.

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Novel effect of antihelminthic ...... c progression in colon cancer.

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Dennis Kobelt

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Dominic Scudiero

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Iduna Fichtner

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Margit Lemm

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Mike Selby

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Peter M Schlag

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Robert H Shoemaker

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Ulrike Sack

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Ulrike Stein

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Wolfgang Walther

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Mts1 regulates the assembly of nonmuscle myosin-IIA

Cancer statistics, 2010

A genetic model for colorectal tumorigenesis

S100 alpha, CAPL, and CACY: molecular cloning and expression analysis of three calcium-binding proteins from human heart

Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling

The anti-helminthic niclosamide inhibits Wnt/Frizzled1 signaling.

S100A4 and metastasis: a small actor playing many roles

Liprin beta 1, a member of the family of LAR transmembrane tyrosine phosphatase-interacting proteins, is a new target for the metastasis-associated protein S100A4 (Mts1).

S100A4 accelerates tumorigenesis and invasion of human prostate cancer through the transcriptional regulation of matrix metalloproteinase 9

Diagnostic and prognostic value of metastasis inducer S100A4 transcripts in plasma of colon, rectal, and gastric cancer patients.

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