Autophagy suppression promotes apoptotic cell death in response to inhibition of the PI3K-mTOR pathway in pancreatic adenocarcinoma.
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Autophagy in cancerInduction of autophagy is an early response to gefitinib and a potential therapeutic target in breast cancerThe synergistic effect of everolimus and chloroquine on endothelial cell number reduction is paralleled by increased apoptosis and reduced autophagy occurrenceUpregulation of autophagy-related gene-5 (ATG-5) is associated with chemoresistance in human gastric cancerMEK Inhibition Sensitizes Precursor B-Cell Acute Lymphoblastic Leukemia (B-ALL) Cells to Dexamethasone through Modulation of mTOR Activity and Stimulation of AutophagyTargeting the PI3K/mTOR axis, alone and in combination with autophagy blockade, for the treatment of malignant peripheral nerve sheath tumorsAutophagy in oncogenic K-Ras promotes basal extrusion of epithelial cells by degrading S1PAutophagy inhibition for chemosensitization and radiosensitization in cancer: do the preclinical data support this therapeutic strategy?Crosstalk between apoptosis and autophagy: molecular mechanisms and therapeutic strategies in cancer.Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascade inhibitors: how mutations can result in therapy resistance and how to overcome resistance.Combined MTOR and autophagy inhibition: phase I trial of hydroxychloroquine and temsirolimus in patients with advanced solid tumors and melanoma.Combined efficacy of cediranib and quinacrine in glioma is enhanced by hypoxia and causally linked to autophagic vacuole accumulation.Bafilomycin A1 targets both autophagy and apoptosis pathways in pediatric B-cell acute lymphoblastic leukemiaAntagonistic effects of chloroquine on autophagy occurrence potentiate the anticancer effects of everolimus on renal cancer cellsSafety and Biologic Response of Pre-operative Autophagy Inhibition in Combination with Gemcitabine in Patients with Pancreatic Adenocarcinoma.Inhibition of autophagy sensitizes malignant pleural mesothelioma cells to dual PI3K/mTOR inhibitorsAutophagic degradation of aquaporin-2 is an early event in hypokalemia-induced nephrogenic diabetes insipidusA dual PI3K/AKT/mTOR signaling inhibitor miR-99a suppresses endometrial carcinoma.Ambra1 in autophagy and apoptosis: Implications for cell survival and chemotherapy resistance.Superior efficacy of co-treatment with dual PI3K/mTOR inhibitor NVP-BEZ235 and pan-histone deacetylase inhibitor against human pancreatic cancer.Targeting the PI3K/Akt/mTOR pathway for breast cancer therapyAttacking breast cancer at the preinvasion stage by targeting autophagy.The autophagy inhibitor verteporfin moderately enhances the antitumor activity of gemcitabine in a pancreatic ductal adenocarcinoma model.Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment.Quinacrine synergistically enhances the antivascular and antitumor efficacy of cediranib in intracranial mouse gliomaPhosphatidylinositol 3-kinase (PI3K) inhibitors as cancer therapeutics.Phospho-Akt overexpression is prognostic and can be used to tailor the synergistic interaction of Akt inhibitors with gemcitabine in pancreatic cancer.Class I phosphatidylinositol 3-kinase inhibitors for cancer therapy.mTOR pathway in colorectal cancer: an update.PI3K and Akt as molecular targets for cancer therapy: current clinical outcomes.A phase II study of SB939, a novel pan-histone deacetylase inhibitor, in patients with translocation-associated recurrent/metastatic sarcomas-NCIC-CTG IND 200†.Targeting cancer cell metabolism in pancreatic adenocarcinoma.Autophagy in 5-Fluorouracil Therapy in Gastrointestinal Cancer: Trends and Challenges.Inhibition of cholesterol metabolism underlies synergy between mTOR pathway inhibition and chloroquine in bladder cancer cells.Targeting the mTOR pathway in breast cancer.Autophagy inhibition enhances colorectal cancer apoptosis induced by dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235.The dual PI3K/mTOR inhibitor NVP-BEZ235 and chloroquine synergize to trigger apoptosis via mitochondrial-lysosomal cross-talk.Nutrient availability alters the effect of autophagy on sulindac sulfide-induced colon cancer cell apoptosis.Proteins regulating the intercellular transfer and function of P-glycoprotein in multidrug-resistant cancer.A novel polyamine blockade therapy activates an anti-tumor immune response.
P2860
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P2860
Autophagy suppression promotes apoptotic cell death in response to inhibition of the PI3K-mTOR pathway in pancreatic adenocarcinoma.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Autophagy suppression promotes ...... in pancreatic adenocarcinoma.
@en
Autophagy suppression promotes ...... in pancreatic adenocarcinoma.
@nl
type
label
Autophagy suppression promotes ...... in pancreatic adenocarcinoma.
@en
Autophagy suppression promotes ...... in pancreatic adenocarcinoma.
@nl
prefLabel
Autophagy suppression promotes ...... in pancreatic adenocarcinoma.
@en
Autophagy suppression promotes ...... in pancreatic adenocarcinoma.
@nl
P2093
P2860
P921
P1476
Autophagy suppression promotes ...... in pancreatic adenocarcinoma.
@en
P2093
Byron Hann
Dana Aftab
Kevan Shokat
Olga K Mirzoeva
W Michael Korn
P2860
P2888
P304
P356
10.1007/S00109-011-0774-Y
P577
2011-06-16T00:00:00Z