Disruption of the Candida albicans TPS1 gene encoding trehalose-6-phosphate synthase impairs formation of hyphae and decreases infectivity.
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In Candida parapsilosis the ATC1 gene encodes for an acid trehalase involved in trehalose hydrolysis, stress resistance and virulence.The trehalose synthesis pathway is an integral part of the virulence composite for Cryptococcus gattii.Systematic screens of a Candida albicans homozygous deletion library decouple morphogenetic switching and pathogenicity.Aspergillus fumigatus Trehalose-Regulatory Subunit Homolog Moonlights To Mediate Cell Wall Homeostasis through Modulation of Chitin Synthase Activity.The thermophilic yeast Hansenula polymorpha does not require trehalose synthesis for growth at high temperatures but does for normal acquisition of thermotolerance.Lack of trehalose accelerates H2O2-induced Candida albicans apoptosis through regulating Ca2+ signaling pathway and caspase activity.Neurospora clock-controlled gene 9 (ccg-9) encodes trehalose synthase: circadian regulation of stress responses and developmentRole of trehalose biosynthesis in Aspergillus fumigatus development, stress response, and virulenceDisruption of the Candida albicans TPS2 gene encoding trehalose-6-phosphate phosphatase decreases infectivity without affecting hypha formation.Trehalose 6-phosphate phosphatase is required for cell wall integrity and fungal virulence but not trehalose biosynthesis in the human fungal pathogen Aspergillus fumigatus.Developmental cell fate and virulence are linked to trehalose homeostasis in Cryptococcus neoformans.Small but crucial: the novel small heat shock protein Hsp21 mediates stress adaptation and virulence in Candida albicans.Trehalose metabolism: from osmoprotection to signaling.Relevance of trehalose in pathogenicity: some general rules, yet many exceptions.Characterizing the in vivo role of trehalose in Saccharomyces cerevisiae using the AGT1 transporter.Niche-specific activation of the oxidative stress response by the pathogenic fungus Candida albicans.Cell Wall Remodeling Enzymes Modulate Fungal Cell Wall Elasticity and Osmotic Stress Resistance.Combined inactivation of the Candida albicans GPR1 and TPS2 genes results in avirulence in a mouse model for systemic infectionDistinct and redundant roles of the two MYST histone acetyltransferases Esa1 and Sas2 in cell growth and morphogenesis of Candida albicans.Structures of trehalose-6-phosphate phosphatase from pathogenic fungi reveal the mechanisms of substrate recognition and catalysisEctopic expression of URA3 can influence the virulence phenotypes and proteome of Candida albicans but can be overcome by targeted reintegration of URA3 at the RPS10 locus.Characterization and regulation of the trehalose synthesis pathway and its importance in the pathogenicity of Cryptococcus neoformansTrehalose pathway as an antifungal target.Central Role of the Trehalose Biosynthesis Pathway in the Pathogenesis of Human Fungal Infections: Opportunities and Challenges for Therapeutic Development.Isolation of the MIG1 gene from Candida albicans and effects of its disruption on catabolite repression.Trehalose synthesis and metabolism are required at different stages of plant infection by Magnaporthe grisea.Structural and In Vivo Studies on Trehalose-6-Phosphate Synthase from Pathogenic Fungi Provide Insights into Its Catalytic Mechanism, Biological Necessity, and Potential for Novel Antifungal Drug Design.Trehalose as antifungal target: The picture is still incomplete.Tight control of trehalose content is required for efficient heat-induced cell elongation in Candida albicansRole of nitrogen and carbon transport, regulation, and metabolism genes for Saccharomyces cerevisiae survival in vivo.Glucose promotes stress resistance in the fungal pathogen Candida albicans.New Horizons in Antifungal Therapy.
P2860
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P2860
Disruption of the Candida albicans TPS1 gene encoding trehalose-6-phosphate synthase impairs formation of hyphae and decreases infectivity.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
1998年论文
@zh
1998年论文
@zh-cn
name
Disruption of the Candida albi ...... hae and decreases infectivity.
@en
Disruption of the Candida albi ...... hae and decreases infectivity.
@nl
type
label
Disruption of the Candida albi ...... hae and decreases infectivity.
@en
Disruption of the Candida albi ...... hae and decreases infectivity.
@nl
prefLabel
Disruption of the Candida albi ...... hae and decreases infectivity.
@en
Disruption of the Candida albi ...... hae and decreases infectivity.
@nl
P2093
P2860
P1476
Disruption of the Candida albi ...... phae and decreases infectivity
@en
P2093
M A Blazquez
O Zaragoza
P2860
P304
P407
P577
1998-08-01T00:00:00Z