The Notch ligand Jagged2 promotes lung adenocarcinoma metastasis through a miR-200-dependent pathway in mice - Wikidata - awgldk - TriplyDB

The Notch ligand Jagged2 promotes lung adenocarcinoma metastasis through a miR-200-dependent pathway in mice

The Notch ligand Jagged2 promotes lung adenocarcinoma metastasis through a miR-200-dependent pathway in mice

http://www.wikidata.org/entity/Q39576164

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Targeting Notch to overcome radiation resistance Roles of NOTCH1 as a Therapeutic Target and a Biomarker for Lung Cancer: Controversies and Perspectives MicroRNA regulation of tumorigenesis, cancer progression and interpatient heterogeneity: towards clinical use Non-coding RNAs in lung cancer MiR-200, a new star miRNA in human cancer From fly wings to targeted cancer therapies: a centennial for notch signaling The miR-200 and miR-221/222 microRNA families: opposing effects on epithelial identity Smoking, p53 mutation, and lung cancer Noncoding RNAs in Tumor Epithelial-to-Mesenchymal Transition microRNA-200b as a Switch for Inducible Adult Angiogenesis Significance of PELP1/HDAC2/miR-200 regulatory network in EMT and metastasis of breast cancer The miR-200 family and the miR-183~96~182 cluster target Foxf2 to inhibit invasion and metastasis in lung cancers.Common Oncogene Mutations and Novel SND1-BRAF Transcript Fusion in Lung Adenocarcinoma from Never Smokers Epithelial-to-mesenchymal transition drives a pro-metastatic Golgi compaction process through scaffolding protein PAQR11.ZEB1 sensitizes lung adenocarcinoma to metastasis suppression by PI3K antagonism.Expression of Notch Gene and Its Impact on Survival of Patients with Resectable Non-small Cell Lung Cancer.Histone deacetylases, microRNA and leptin crosstalk in pancreatic cancer.Members of the microRNA-200 family are promising therapeutic targets in cancer.Combinatorial interventions inhibit TGFβ-driven epithelial-to-mesenchymal transition and support hybrid cellular phenotypes.The RNA-binding protein DDX1 promotes primary microRNA maturation and inhibits ovarian tumor progression.Downregulation of endothelial microRNA-200b supports cutaneous wound angiogenesis by desilencing GATA binding protein 2 and vascular endothelial growth factor receptor 2 A microRNA network regulates expression and biosynthesis of wild-type and DeltaF508 mutant cystic fibrosis transmembrane conductance regulator.The cell of origin and subtype of K-Ras-induced lung tumors are modified by Notch and Sox2.Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression.Notch3 and HEY-1 as prognostic biomarkers in pancreatic adenocarcinoma.Alveolar type II cells possess the capability of initiating lung tumor development Notch signaling and EMT in non-small cell lung cancer: biological significance and therapeutic application.Signaling mechanisms of the epithelial-mesenchymal transition.Pro-Inflammatory Cytokine IL-1β Up-Regulates CXC Chemokine Receptor 4 via Notch and ERK Signaling Pathways in Tongue Squamous Cell Carcinoma.BMP4 depletion by miR-200 inhibits tumorigenesis and metastasis of lung adenocarcinoma cells.MicroRNAs as potential targets for progressive pulmonary fibrosis The sialyl-glycolipid stage-specific embryonic antigen 4 marks a subpopulation of chemotherapy-resistant breast cancer cells with mesenchymal features.The microRNA-200/Zeb1 axis regulates ECM-dependent β1-integrin/FAK signaling, cancer cell invasion and metastasis through CRKL CXCR2 expression in tumor cells is a poor prognostic factor and promotes invasion and metastasis in lung adenocarcinoma.Notch increases the shedding of HB-EGF by ADAM12 to potentiate invadopodia formation in hypoxia.Control of alveolar differentiation by the lineage transcription factors GATA6 and HOPX inhibits lung adenocarcinoma metastasis The role of epithelial-mesenchymal transition programming in invasion and metastasis: a clinical perspective.Integrative genetic, epigenetic and pathological analysis of paraganglioma reveals complex dysregulation of NOTCH signaling.Hsa-miR-329 exerts tumor suppressor function through down-regulation of MET in non-small cell lung cancer.High expression of Notch ligand Jagged2 is associated with the metastasis and recurrence in urothelial carcinoma of bladder.

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The Notch ligand Jagged2 promotes lung adenocarcinoma metastasis through a miR-200-dependent pathway in mice

http://www.wikidata.org/entity/Q39576164

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2011年论文

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2011年论文

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name

The Notch ligand Jagged2 promo ...... -200-dependent pathway in mice

@en

The Notch ligand Jagged2 promo ...... 200-dependent pathway in mice.

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type

label

The Notch ligand Jagged2 promo ...... -200-dependent pathway in mice

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The Notch ligand Jagged2 promo ...... 200-dependent pathway in mice.

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The Notch ligand Jagged2 promo ...... -200-dependent pathway in mice

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The Notch ligand Jagged2 promo ...... 200-dependent pathway in mice.

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Journal of Clinical Investigation

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The Notch ligand Jagged2 promo ...... -200-dependent pathway in mice

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P2093

Chad J Creighton

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Cristina A Alvarez

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Don L Gibbons

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Jonathan M Kurie

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Nishan Thilaganathan

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Wei Lin

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Yanan Yang

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Yi Zang

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Young-Ho Ahn

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Twist transcriptionally up-regulates AKT2 in breast cancer cells leading to increased migration, invasion, and resistance to paclitaxel

Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin.

Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2

The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2

Contextual extracellular cues promote tumor cell EMT and metastasis by regulating miR-200 family expression

GATA-3 and the regulation of the mammary luminal cell fate

A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells

The epithelial-mesenchymal transition generates cells with properties of stem cells

Highly tumorigenic lung cancer CD133+ cells display stem-like features and are spared by cisplatin treatment

GATA-3 links tumor differentiation and dissemination in a luminal breast cancer model

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1373-1385

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10.1172/JCI42579

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4

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121

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Daniel C Moreira

Gregory J Goodall

Philip A Gregory

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2011-03-14T00:00:00Z

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50395554

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21403400

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3069760

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