about
Structural evolutions of salicylaldoximes as selective agonists for estrogen receptor betaPredictive models, based on classification algorithms, for compounds potentially active as mitochondrial ATP-sensitive potassium channel openers.Ceramide analogues in apoptosis: a new strategy for anticancer drug development.Arylthioamides as H2S Donors: l-Cysteine-Activated Releasing Properties and Vascular Effects in Vitro and in VivoCombined inhibition of AKT/mTOR and MDM2 enhances Glioblastoma Multiforme cell apoptosis and differentiation of cancer stem cells.Design, Synthesis, and Evaluation of Thyronamine Analogues as Novel Potent Mouse Trace Amine Associated Receptor 1 (mTAAR1) Agonists.Cardiac ATP-sensitive potassium channels: a potential target for an anti-ischaemic pharmacological strategy.New emerging prospects in the pharmacotherapy of hypertension.P-gp transporter and its role in neurodegenerative diseases.Novel adenosine 5'-triphosphate-sensitive potassium channel ligands: a patent overview (2005-2010).Mitochondrial potassium channels as pharmacological target for cardioprotective drugs.Locking PDK1 in DFG-out conformation through 2-oxo-indole containing molecules: Another tools to fight glioblastoma.Design and synthesis of 2-oxindole based multi-targeted inhibitors of PDK1/Akt signaling pathway for the treatment of glioblastoma multiforme.Synthesis and pharmacological evaluation of multifunctional tacrine derivatives against several disease pathways of AD.Synthesis of Novel 3,5-Disubstituted-2-oxindole Derivatives As Antitumor Agents against Human Nonsmall Cell Lung Cancer.SAR study on arylmethyloxyphenyl scaffold: looking for a P-gp nanomolar affinity.Discovery of novel rivastigmine-hydroxycinnamic acid hybrids as multi-targeted agents for Alzheimer's disease.Oxidative Stress, Mitochondrial Abnormalities and Proteins Deposition: Multitarget Approaches in Alzheimer's Disease.Synthesis and biological evaluation of 5-membered spiro heterocycle-benzopyran derivatives against myocardial ischemia.Anti-ischemic properties of a new spiro-cyclic benzopyran activator of the cardiac mito-KATP channel.Monoaryl-substituted salicylaldoximes as ligands for estrogen receptor beta.Synthesis and biological evaluation of (hetero)arylmethyloxy- and arylmethylamine-phenyl derivatives as potent P-glycoprotein modulating agents.Arylmethyloxyphenyl derivatives: small molecules displaying P-glycoprotein inhibition.Variously substituted (phosphonoacetamido)oxy analogues of geranylgeranyl diphosphate (GGdP) as GGdP-transferase (GGTase) inhibitors and antiproliferative agents.Synthesis of a resveratrol analogue with high ceramide-mediated proapoptotic activity on human breast cancer cells.New N-arylsulfonyl-N-alkoxyaminoacetohydroxamic acids as selective inhibitors of gelatinase A (MMP-2).Synthesis of heteroaromatic analogues of (2-aryl-1-cyclopentenyl-1-alkylidene)-(arylmethyloxy)amine COX-2 inhibitors: effects on the inhibitory activity of the replacement of the cyclopentene central core with pyrazole, thiophene or isoxazole ring.Aryl-substituted methyleneaminoxymethyl (MAOM) analogues of diarylcyclopentenyl cyclooxygenase-2 inhibitors: effects of some structural modifications on their biological properties.(E)-[2-(4-Methylsulphonylphenyl)-1-cyclopentenyl-1-methyliden](arylmethyloxy)amines. Methyleneaminoxymethyl (MAOM) analogues of diarylcyclopentenyl cyclooxygenase-2 inhibitors: synthesis and biological properties.Enantiopure 3-(arylmethylidene)aminoxy-2-methylpropionic acids: synthesis and antiinflammatory properties.A Novel H2S-releasing Amino-Bisphosphonate which combines bone anti-catabolic and anabolic functions.Synthesis and Functional Evaluation of Novel Aldose Reductase Inhibitors Bearing a Spirobenzopyran ScaffoldDevelopment of classification models for identifying "true" P-glycoprotein (P-gp) inhibitors through inhibition, ATPase activation and monolayer efflux assays.Hydrogen Sulfide: A Worthwhile Tool in the Design of New Multitarget Drugs.Iminothioethers as Hydrogen Sulfide Donors: From the Gasotransmitter Release to the Vascular Effects.Synthesis and inhibitory activity towards human leukocyte elastase of new 7alpha-methoxy and 7alpha-chloro (2-acyloxymethyl) cephem derivatives.Synthesis, antifungal activity, and molecular modeling studies of new inverted oxime ethers of oxiconazole.Conformationally restrained ceramide analogues: effects of lipophilic modifications on the antiproliferative activity.Synthesis, binding affinity, and transcriptional activity of hydroxy- and methoxy-substituted 3,4-diarylsalicylaldoximes on estrogen receptors alpha and beta.Novel estrogen receptor ligands based on an anthranylaldoxime structure: role of the phenol-type pseudocycle in the binding process.
P50
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P50
description
hulumtuese
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Simona Rapposelli
@ast
Simona Rapposelli
@en
Simona Rapposelli
@es
Simona Rapposelli
@nl
Simona Rapposelli
@sl
type
label
Simona Rapposelli
@ast
Simona Rapposelli
@en
Simona Rapposelli
@es
Simona Rapposelli
@nl
Simona Rapposelli
@sl
prefLabel
Simona Rapposelli
@ast
Simona Rapposelli
@en
Simona Rapposelli
@es
Simona Rapposelli
@nl
Simona Rapposelli
@sl
P1053
D-1595-2010
L-8438-2018
P106
P1153
6603018328
P21
P2798
P31
P3829
P496
0000-0003-0146-6358